List of works - Miguel A Martinez

A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease

scientific article

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

scientific article published in August 2003

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.

scientific article published on March 1990

A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals

scientific article published on 26 November 2007

ADAR1 affects HCV infection by modulating innate immune response

scientific article published in 2018

Absence of genetic diversity reduction in the HIV-1 integrated proviral LTR sequence population during successful combination therapy

scientific article published in March 2001

Alleles at rs4273729 in the chromosome 6 do not predict response to peg-interferon-α and ribavirin therapy in hepatitis C virus/HIV-1-coinfected patients

scientific article published in September 2012

Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway

scientific article published on 22 December 2017

Analysis of chemokine and cytokine expression in patients with HIV and GB virus type C coinfection

scientific article published in May 2005

Analysis of recombinant protein toxicity in E. coli through a phage lambda-based genetic screening system.

scientific article published on 4 May 2007

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

scientific article published on March 1994

Antigenic variation of foot-and-mouth disease virus of serotype C during propagation in the field is mainly restricted to only one structural protein (VP1).

scientific article published in December 1989

Antiretroviral therapy-induced functional modification of IgG4 and IgM responses in HIV-1-infected individuals screened by an allosteric biosensor

scientific article

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

scientific article published in Nature Communications

Catalytic efficiency and phenotype of HIV-1 proteases encoding single critical resistance substitutions

scientific article published in August 2002

Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture

scientific article published on 25 July 2013

Clinical trials of repurposed antivirals for SARS-CoV-2

scientific article published on 06 July 2020

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

scientific article published on 13 August 2012

Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection

scientific article published on July 2005

Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain

scientific article published in January 1992

Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis

scientific article published in January 1990

Complete nucleotide sequence of genotype 4 hepatitis C viruses isolated from patients co-infected with human immunodeficiency virus type 1.

scientific article published on 4 October 2006

Compounds with therapeutic potential against novel respiratory 2019 coronavirus

scientific article published on 09 March 2020

Deciphering the interleukin 28B variants that better predict response to pegylated interferon-α and ribavirin therapy in HCV/HIV-1 coinfected patients

scientific article

Deep sequencing: becoming a critical tool in clinical virology

scientific article published on 24 June 2014

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.

scientific article published on 21 May 2014

Differential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection

scientific article published on March 1997

Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture.

scientific article published on May 1993

Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infection: indications for the investigation of new treatment approaches

scientific article published on January 2004

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.

scientific article published on 6 February 2015

Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with </=250/microL CD4 T cells and undetectable plasma virus load

scientific article published in July 1999

Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors

scientific article published in December 1999

Endoribonuclease-prepared short interfering RNAs induce effective and specific inhibition of human immunodeficiency virus type 1 replication

scientific article published on 25 July 2007

Engineering the E. coli beta-galactosidase for the screening of antiviral protease inhibitors

scientific article published in April 2005

Epistasis among deleterious mutations in the HIV-1 protease

scientific article

Epistasis as a determinant of the HIV-1 protease's robustness to mutation

scientific article published on 31 December 2014

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades

scientific article

Evolution of the human immunodeficiency virus type 1 protease: effects on viral replication capacity and protease robustness

scientific article published on 29 August 2012

Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus.

scientific article

Exploring the functional robustness of an enzyme by in vitro evolution

scientific article

Fate of direct and inverted repeats in the RNA hypermutagenesis reaction

scientific article published on January 1996

Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

scientific article

Fitness landscape of human immunodeficiency virus type 1 protease quasispecies

scientific article published on 6 December 2006

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

scientific article published on December 2003

Fixation of mutations at the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock?

scientific article published in July 1991

Foot-and-Mouth Disease Virus Populations Are Quasispecies ⬇️

scientific article published on January 1, 1992

Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype

scientific article published in January 1992

Genetic and catalytic efficiency structure of an HCV protease quasispecies

scientific article published in April 2007

Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus

scientific article published in January 1988

Genetic evolution of GB virus C/hepatitis G virus (GBV-C/HGV) under interferon pressure

scientific article published in May 2000

Genetic evolution of hepatitis G virus in chronically infected individual patients

scientific article published on November 1998

Genetic screen for monitoring hepatitis C virus NS3 serine protease activity

scientific article

Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease

scientific article published on December 2004

HIV-1 Protease Evolvability Is Affected by Synonymous Nucleotide Recoding

article

HIV-1 lethality and loss of Env protein expression induced by single synonymous substitutions in the virus genome intronic splicing silencer

scientific article published on 19 August 2020

HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions

scientific article

HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

scientific article published on 04 March 2008

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

scientific article published on 28 June 2012

Hepatitis C virus NS3/4A quasispecies diversity in acute hepatitis C infection in HIV-1 co-infected patients

scientific article published on 27 March 2014

High-throughput, functional screening of the anti-HIV-1 humoral response by an enzymatic nanosensor

article

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

scientific article published on 26 April 2016

Human immunodeficiency virus type 1 genetic evolution in patients with prolonged suppression of plasma viremia

scientific article published in April 1999

Human immunodeficiency virus type 1 population bottleneck during indinavir therapy causes a genetic drift in the env quasispecies

scientific article published in January 2000

IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients

scientific article published on January 2014

IL28B SNP rs8099917 is strongly associated with pegylated interferon-α and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients

scientific article

Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission

scientific article

Inhibition of HIV-1 replication by RNA targeted against the LTR region

scientific article

Inhibition of HIV-1 replication by an improved hairpin ribozyme that includes an RNA decoy

scientific article published on 20 April 2005

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

scientific article

Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy

scientific article published on 5 April 2004

Large-scale screening of circulating microRNAs in individuals with HIV-1 mono-infections reveals specific liver damage signatures

article

Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes

scientific article published in July 2004

Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure

scientific article published on 23 August 2010

Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region

scientific article published on 17 July 2008

Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients

scientific article published on 22 March 2014

Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN

scientific article published on 25 March 2004

Mutational Patterns Associated with the 69 Insertion Complex in Multi-drug-resistant HIV-1 Reverse Transcriptase that Confer Increased Excision Activity and High-level Resistance to Zidovudine

article

Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.

scientific article published in July 1999

Natural prevalence of HCV minority variants that are highly resistant to NS3/4A protease inhibitors

scientific article published on 30 June 2011

New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection.

scientific article

No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

scientific article published on 3 October 2013

Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission

scientific article published on August 1998

Prevalence and route of transmission of infection with a novel DNA virus (TTV), hepatitis C virus, and hepatitis G virus in patients infected with HIV.

scientific article published in January 2000

Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses.

scientific article published on May 2006

Quantification of integrated and total HIV-1 DNA after long-term highly active antiretroviral therapy in HIV-1-infected patients

scientific article

RNA interference as a tool for exploring HIV-1 robustness

scientific article published on 22 August 2011

RNA interference of HIV replication

scientific article

Rapid spread and genetic diversification of HIV type 1 subtype C in a rural area of southern Mozambique

scientific article published on February 2008

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity

scientific article

Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region

scientific article published on 21 February 2007

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

scientific article published on August 2004

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

article

Resumen de congreso: 20 años después del primer Simposium Internacional sobre el virus de la hepatitis C y otros virus relacionados

scientific article published on 05 September 2013

Reverse transcriptase and substrate dependence of the RNA hypermutagenesis reaction.

scientific article published on July 1995

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

scientific article

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

scientific article

Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.

scientific article published on August 1999

Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs.

scientific article published on January 2006

Similarities between Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Genetic and Phenotypic Protease Quasispecies Diversity

scientific article

Strong epistatic interactions within a single protein

scientific article published on 28 March 2014

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

article

Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness

scientific article

Therapy Implications of Hepatitis C Virus Genetic Diversity

scientific article published on 29 December 2020

Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase.

scientific article published on 19 April 2011

Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.

scientific article published on 29 September 2009

Two mechanisms of antigenic diversification of foot-and-mouth disease virus

scientific article published in October 1991

Unfinished stories on viral quasispecies and Darwinian views of evolution.

scientific article published on 10 February 2010

Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants.

scientific article published on January 1997

List of works by Miguel A Martinez

A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.

A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals

ADAR1 affects HCV infection by modulating innate immune response

Absence of genetic diversity reduction in the HIV-1 integrated proviral LTR sequence population during successful combination therapy

Alleles at rs4273729 in the chromosome 6 do not predict response to peg-interferon-α and ribavirin therapy in hepatitis C virus/HIV-1-coinfected patients

Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway

Analysis of chemokine and cytokine expression in patients with HIV and GB virus type C coinfection

Analysis of recombinant protein toxicity in E. coli through a phage lambda-based genetic screening system.

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

Antigenic variation of foot-and-mouth disease virus of serotype C during propagation in the field is mainly restricted to only one structural protein (VP1).

Antiretroviral therapy-induced functional modification of IgG4 and IgM responses in HIV-1-infected individuals screened by an allosteric biosensor

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

Catalytic efficiency and phenotype of HIV-1 proteases encoding single critical resistance substitutions

Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture

Clinical trials of repurposed antivirals for SARS-CoV-2

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection

Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain

Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis

Complete nucleotide sequence of genotype 4 hepatitis C viruses isolated from patients co-infected with human immunodeficiency virus type 1.

Compounds with therapeutic potential against novel respiratory 2019 coronavirus

Deciphering the interleukin 28B variants that better predict response to pegylated interferon-α and ribavirin therapy in HCV/HIV-1 coinfected patients

Deep sequencing: becoming a critical tool in clinical virology

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.

Differential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection

Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture.

Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infection: indications for the investigation of new treatment approaches

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.

Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with </=250/microL CD4 T cells and undetectable plasma virus load

Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors

Endoribonuclease-prepared short interfering RNAs induce effective and specific inhibition of human immunodeficiency virus type 1 replication

Engineering the E. coli beta-galactosidase for the screening of antiviral protease inhibitors

Epistasis among deleterious mutations in the HIV-1 protease

Epistasis as a determinant of the HIV-1 protease's robustness to mutation

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades

Evolution of the human immunodeficiency virus type 1 protease: effects on viral replication capacity and protease robustness

Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus.

Exploring the functional robustness of an enzyme by in vitro evolution

Fate of direct and inverted repeats in the RNA hypermutagenesis reaction

Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

Fitness landscape of human immunodeficiency virus type 1 protease quasispecies

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

Fixation of mutations at the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock?

Foot-and-Mouth Disease Virus Populations Are Quasispecies ⬇️

Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype

Genetic and catalytic efficiency structure of an HCV protease quasispecies

Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus

Genetic evolution of GB virus C/hepatitis G virus (GBV-C/HGV) under interferon pressure

Genetic evolution of hepatitis G virus in chronically infected individual patients

Genetic screen for monitoring hepatitis C virus NS3 serine protease activity

Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease

HIV-1 Protease Evolvability Is Affected by Synonymous Nucleotide Recoding

HIV-1 lethality and loss of Env protein expression induced by single synonymous substitutions in the virus genome intronic splicing silencer

HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions

HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

Hepatitis C virus NS3/4A quasispecies diversity in acute hepatitis C infection in HIV-1 co-infected patients

High-throughput, functional screening of the anti-HIV-1 humoral response by an enzymatic nanosensor

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

Human immunodeficiency virus type 1 genetic evolution in patients with prolonged suppression of plasma viremia

Human immunodeficiency virus type 1 population bottleneck during indinavir therapy causes a genetic drift in the env quasispecies

IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients

IL28B SNP rs8099917 is strongly associated with pegylated interferon-α and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients

Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission

Inhibition of HIV-1 replication by RNA targeted against the LTR region

Inhibition of HIV-1 replication by an improved hairpin ribozyme that includes an RNA decoy

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy

Large-scale screening of circulating microRNAs in individuals with HIV-1 mono-infections reveals specific liver damage signatures

Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes

Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure

Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region

Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients

Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN

Mutational Patterns Associated with the 69 Insertion Complex in Multi-drug-resistant HIV-1 Reverse Transcriptase that Confer Increased Excision Activity and High-level Resistance to Zidovudine

Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.

Natural prevalence of HCV minority variants that are highly resistant to NS3/4A protease inhibitors