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List of works by Sylvie Garneau-Tsodikova

2348 Lafora disease premature termination codons (PTCs) are likely candidates for suppression by aminoglycosides

6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes

scientific article published on 12 April 2012

A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.

scientific article published on 6 April 2016

A combination approach to treating fungal infections

scientific article

A complex game of hide and seek: the search for new antifungals

scientific article published on 17 May 2016

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

scientific article published on 06 March 2020

A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline

scientific article

A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis

scientific article published on 24 December 2008

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

article published in 2013

A random sequential mechanism of aminoglycoside acetylation by Mycobacterium tuberculosis Eis protein ⬇️

scientific article

A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides

scientific article published on 19 November 2015

Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight

scientific article published on 18 January 2018

Activation and Loading of the Starter Unit during Thiocoraline Biosynthesis

scientific article

Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry

scientific article published on February 2006

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

article

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

scientific article

Aminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition

scientific article

Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents

scientific article published in June 2015

Amyloid-β probes: Review of structure-activity and brain-kinetics relationships

scientific article published on 28 May 2013

Antibiotic Resistance themed issue

scholarly article by Sylvie Garneau-Tsodikova & Gerard D. Wright published 2016 in MedChemComm

Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.

scientific article published on 19 January 2017

Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG.

scientific article published on 24 September 2014

Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity

scientific article

Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap?

scientific article published on 21 June 2016

Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance

scientific article published in March 2011

Automated genome mining for natural products.

scientific article

Back Cover: Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity (ChemMedChem 14/2016)

Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis

scientific article

Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis

scientific article

Biological formation of pyrroles: nature's logic and enzymatic machinery

scientific article published on 15 June 2006

Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

scientific article published on 10 October 2016

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

scientific article published on 16 October 2020

Carbohydrates themed issue

Chapter 7. Emerging Targets in Anti-Tubercular Drug Design

Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis

scientific article published on 4 April 2008

Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster

scientific article

Characterization of a Unique Interrupted Adenylation Domain That Can Catalyze Three Reactions

scientific article published on 30 December 2019

Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis

scientific article

Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase Eis

scientific article

Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

scientific article published on 30 July 2015

Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7†

scientific article published in 2007

Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

scientific article published on 13 February 2017

Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly

scientific article published on 24 December 2019

Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria

scientific article published on 04 May 2015

Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities

scientific article published on 3 January 2018

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity

scientific article published on 30 March 2015

Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis

scientific article

Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis.

scientific article published in June 2007

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

scientific article published on 15 July 2015

Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway

scientific article

Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains

scientific article published on 7 November 2017

Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall.

scientific article published in May 2018

Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus

scientific article

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis

scientific article

Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals

Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils

scientific article published on 18 December 2015

Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis

scientific article

Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis

scientific article

Discovery of inhibitors of Bacillus anthracis primase DnaG.

scientific article published on 19 September 2013

Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4').

scientific article published on 30 October 2010

Distorted Gold(I)-Phosphine Complexes as Antifungal Agents

scientific article published on 16 December 2019

Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens

scientific article published on 26 February 2013

Editorial: natural products themed issue

Effects of altering aminoglycoside structures on bacterial resistance enzyme activities

scientific article published on 2 May 2011

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

scientific article

Engineering Bifunctional Enzymes Capable of Adenylating and Selectively Methylating the Side Chain or Core of Amino Acids

scientific article published on 2 February 2018

Enzymatic Evidence for a Revised Congocidine Biosynthetic Pathway

article

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

scientific article

Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical Isolates

scientific article published on 20 December 2017

Exact and user-friendly kinetic analysis of the two-step rapid equilibrium Michaelis–Menten mechanism

scientific article published in 2009

Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and Truncation

scientific article published on 12 September 2016

Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme

scientific article published on 29 April 2016

Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides

scientific article published in January 2010

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry

scientific article published on October 2006

Flipping the Switch "On" for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed!

scientific article

Glutamyl Adenylate Analogues Are Inhibitors of Glutamyl-tRNA Synthetase

article

High throughput LSPR and SERS analysis of aminoglycoside antibiotics

scientific article published on 14 July 2016

Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation

scientific article published in November 2004

Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis

scientific article

Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity

scientific article

Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK

article

In Vitro Assays to Identify Antibiotics Targeting DNA Metabolism

scientific article published in January 2017

Influence of linker length and composition on enzymatic activity and ribosomal binding of neomycin dimers.

scientific article published on 20 April 2015

Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts

scientific article published on 4 May 2015

Inhibition of glioma progression by a newly discovered CD38 inhibitor.

scientific article

Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1.

scientific article

Interfering With DNA Decondensation as a Strategy Against Mycobacteria

scientific article published in 2018

Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

scientific article

Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives

scientific article published on 21 February 2019

Investigation of the role of linker moieties in bifunctional tacrine hybrids

scientific article published on 14 March 2013

Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307.

scientific article

KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis

scientific article

Making figures: are you taking the best approach to maximize visibility?

Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives

scientific article published on 21 September 2015

Meet the MedChemComm Editorial Board

Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes

scientific article published on 21 February 2020

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia

scientific article published on 24 November 2020

N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents

scientific article published on 18 December 2018

Nature's inventory of halogenation catalysts: oxidative strategies predominate

scientific article

New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents.

scientific article

New trends in aminoglycosides use.

scientific article

Novel alkylated azoles as potent antifungals

scientific article published on 31 March 2017

Novel fluconazole derivatives with promising antifungal activity

scientific article published on 17 December 2017

Novel zafirlukast derivatives exhibit selective antibacterial activity against Porphyromonas gingivalis

scientific article published on 10 June 2019

Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'--phosphotransferase type IIa

scientific article published on 16 July 2018

Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis

scientific article published on 30 March 2018

Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis

scientific article

Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis

scientific article published on 21 August 2019

Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation

scientific article published on 01 January 2019

Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.

scientific article published in October 2006

Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

scientific article published in October 2003

Protein kinase inhibitors in the treatment of pulmonary fibrosis

scientific article published on January 2008

Protein posttranslational modifications: the chemistry of proteome diversifications

scientific article

Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM

scholarly article published in Nature Communications

Purification and characterization of brochocin A and brochocin B(10-43), a functional fragment generated by heterologous expression in Carnobacterium piscicola

scientific article

Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) library ⬇️

scientific article published on 23 February 2015

Recent developments in bisintercalator natural products

scientific article published on September 2010

Redesign of cosubstrate specificity and identification of important residues for substrate binding to hChAT.

scientific article published in July 2010

Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from Mycobacterium tuberculosis

scientific article published on 16 July 2013

Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections

scientific article published on 19 July 2017

Resistance in tuberculosis: what do we know and where can we go?

scientific article published on 23 July 2013

Resisting resistance: gearing up for war

scientific article published on 07 August 2019

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

scientific article

Second Generation of Zafirlukast Derivatives with Improved Activity against the Oral Pathogen Porphyromonas gingivalis

scientific article published on 18 March 2020

Special Series: Natural products at the core of drug discovery

scientific article published in 2010

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

scientific article

Structural basis for backbone N-methylation by an interrupted adenylation domain.

scientific article published on 19 March 2018

Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis

scientific article published on 18 May 2020

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis

scientific article

Synergistic combinations of azoles and antihistamines against Candida species in vitro

article

Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

scientific article

Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides

scientific article

Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance

scientific article published on July 2013

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

scientific article

Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b.

scientific article

Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates

scientific article published on 14 November 2018

Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase

The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.

scientific article published on 8 April 2015

The future of aminoglycosides: the end or renaissance?

scientific article published on May 2010

The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI

scientific article

Tobramycin Variants with Enhanced Ribosome-Targeting Activity

scientific article published on 17 June 2015

Two-peptide bacteriocins produced by lactic acid bacteria

scientific article

Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes

scientific article published on 11 December 2012

Unimodular Methylation by Adenylation-Thiolation Domains Containing an Embedded Methyltransferase

scientific article published on 10 September 2020

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

scientific article

Unusual substrate and halide versatility of phenolic halogenase PltM

Using MbtH-Like Proteins to Alter the Substrate Profile of a Nonribosomal Peptide Adenylation Enzyme

scientific article published on 04 October 2018

What are the drugs of the future?

scientific article published on 23 April 2018

What is medicinal chemistry? - Demystifying a rapidly evolving discipline!

Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice.

scientific article published on 25 May 2017

hChAT: a tool for the chemoenzymatic generation of potential acetyl/butyrylcholinesterase inhibitors.

scientific article published in September 2009

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