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List of works by Andrew G Bowie

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

scientific article

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance

scientific article

A novel anti-viral role for STAT3 in IFN-α signalling responses

scientific article published on 17 December 2016

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

scientific article published on August 2000

Activation of host pattern recognition receptors by viruses.

scientific article published on 09 June 2010

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

scientific article

Alum Activates the Bovine NLRP3 Inflammasome.

scientific article published on 9 November 2017

An arms race: innate antiviral responses and counteracting viral strategies.

scientific article published on December 2007

Characterisation of viral proteins that inhibit Toll-like receptor signal transduction

scientific article published in January 2009

Cytosolic DNA sensors regulating type I interferon induction.

scientific article

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

scientific article

Evaluating the role of Toll-like receptors in diseases of the central nervous system

scientific article published on 15 January 2011

Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?

scientific article published on 01 August 1993

Harnessing poxviral know-how for anti-cytokine therapies

scientific article published on 01 March 2019

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α ⬇️

scientific article published on May 23, 2011

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

scientific article published on 13 February 2017

IFI16 is an innate immune sensor for intracellular DNA

scientific article

Immune sensing of DNA

scientific article published on May 2013

Innate DNA sensing moves to the nucleus

scientific article published on 01 May 2011

Innate antiviral signalling in the central nervous system

scientific article published on 06 December 2013

Innate immune activation of NFκB and its antagonism by poxviruses

scientific article published on 11 July 2014

Innate immune detection of microbial nucleic acids.

scientific article

Innate immune recognition of DNA: A recent history

scientific article

Innate sensing of bacterial cyclic dinucleotides: more than just STING ⬇️

scientific article published on December 1, 2012

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2.

scientific article published on June 2008

Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transf

scientific article published on October 1997

Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?

scientific article published on 01 October 2005

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

scientific article

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

scientific article

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

scientific article published on 11 August 2021

Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells

scientific article published on February 1996

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

scientific article

Multi-omics characterization of the monkeypox virus infection

scientific article published in 2024

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

scientific article published on 3 October 2012

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

scholarly article by Gillian Dunphy published in September 2018

Novel strategies for targeting innate immune responses to influenza.

scientific article published on 27 January 2016

Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor

scientific article published in Journal of Biological Chemistry

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

scientific article

PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells

scientific article published on 26 February 2020

Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

scientific article published on 14 June 2007

Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitme

scientific article published on 10 October 2013

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses

scientific article published in Journal of Biological Chemistry

Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3

scientific article

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

scientific article published on 3 June 2015

Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors

scientific article published on 23 June 2004

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

scientific article published on 23 January 2013

RIG-I: tri-ing to discriminate between self and non-self RNA.

scientific article published on 16 February 2007

Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation

scientific article published on June 2014

Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells

scientific article published on 01 February 2000

Recognition of herpesviruses by the innate immune system

scientific article published on February 2011

Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

scientific article published in September 2013

Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.

scientific article published on 06 August 2008

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter

scientific article

SARM: From immune regulator to cell executioner

scientific article published on 08 January 2019

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1

scientific journal article

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

scientific article published on November 2016

Self-RNA sentinels signal viral invasion.

scientific article published in January 2018

Sensing and signaling in antiviral innate immunity

scientific article published on April 2010

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

scientific article

Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells

scientific article published on February 1997

TLR3 in antiviral immunity: key player or bystander?

scientific article

TRAF3: Uncovering the Real but Restricted Role in Human ⬇️

scientific article published on September 24, 2010

TRAM is required for TLR2 endosomal signaling to type I IFN induction

scientific article

TRIM-ing down Tolls

scientific article published on 01 April 2008

The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine ⬇️

scientific article published on October 14, 2011

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3 ⬇️

scientific article published on March 6, 2012

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

scientific article

The Toll-IL-1 receptor adaptor family grows to five members.

scientific article

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

scientific article published on 29 February 2016

The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.

scientific article published on November 1993

The emerging role of human PYHIN proteins in innate immunity: implications for health and disease

scientific article published on 06 September 2014

The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats

scientific article

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

scientific article (publication date: May 2007)

The history of Toll-like receptors - redefining innate immunity.

scientific article published on 17 May 2013

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

scientific article published on 10 September 2006

The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1.

scientific article published on February 1995

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

scientific article published on 23 June 2010

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

scientific article

The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.

scientific article

Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

scientific article published on 26 September 2019

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

scientific article published on 11 December 2017

Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake

scientific article published on 18 August 2011

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1

scientific article

Uncovering novel gene function in Toll-like receptor signalling using siRNA.

scientific article published in January 2009

Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways.

scientific article published in April 2010

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

scientific article

Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10

scientific article

Viral activation of macrophages through TLR-dependent and -independent pathways

scientific article

Viral evasion and subversion of pattern-recognition receptor signalling

scientific article published on December 2008

Viral immune modulators perturb the human molecular network by common and unique strategies

scientific article

Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells

scientific article published on December 2005

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule

scientific article published on 27 August 2010

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation

scientific article

Vitamin C inhibits NF kappa B activation in endothelial cells

scientific article published on February 1997

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

scientific article

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