List of works by Darren J Creek

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

scientific article published on 05 March 2019

A High Parasite Density Environment Induces Transcriptional Changes and Cell Death in Plasmodium falciparum Blood Stages

scientific article published on 27 December 2017

A molecular mechanism for eflornithine resistance in African trypanosomes

scientific article

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis.

scientific article published on 09 August 2016

Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa.

scientific article published on 9 April 2018

An attenuated total reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells

scientific article published on April 2015

An oncogenic role for sphingosine kinase 2.

scientific article published on 30 August 2016

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

scientific article published on 16 December 2015

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

scientific article published on 22 August 2006

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei

scientific article (publication date: July 2014)

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

scientific article (publication date: May 2014)

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

scientific article published on 23 February 2015

Chemoresistant Cancer Cell Lines Are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations

scientific article published on 02 June 2022

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

scientific article published on 04 July 2019

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

scientific article published on 08 January 2019

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

scientific article published on 7 May 2007

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

scientific article

Determination of antiprotozoal drug mechanisms by metabolomics approaches.

scientific article published on 05 June 2013

Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics

scholarly article by Anubhav Srivastava published in November 2018

Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.

scientific article published in February 2012

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

scientific article published on 18 January 2016

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

scientific article

Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia

scientific article published on February 2017

Global Metabolic Analyses of Acinetobacter baumannii

scientific article published on 01 January 2019

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

scientific article published on 29 February 2016

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

scientific article

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline).

scientific article published on 16 April 2018

IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data

scientific article

Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria

scientific article

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

scientific article published on 07 August 2013

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

scientific article published in November 2007

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

scientific article published on 11 November 2021

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

scientific article published in August 2005

Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

scientific article published on 13 February 2020

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR

scholarly article by Maytham Hussein et al published 2018 in Computational and Structural Biotechnology Journal

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant

scientific article published in 2018

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs

scientific article published on 6 July 2015

Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris

scientific article published on 06 November 2020

Metabolomic analysis of trypanosomatid protozoa

scientific article published on 19 October 2011

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

scientific article published on 20 December 2019

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. ⬇️

scientific article published on 09 April 2013

Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes

scientific article

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

scientific article

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

scientific article published on 13 December 2019

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

scientific article published on 27 March 2017

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

scientific article published on 3 April 2018

NormalizeMets: assessing, selecting and implementing statistical methods for normalizing metabolomics data

scientific article published on 20 March 2018

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells

scientific article published on 22 September 2016

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

scientific article published on 05 June 2019

Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

scientific article published on 02 December 2019

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

scientific article published on 20 December 2017

Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry

scientific article

Peroxide Antimalarial Drugs Target Redox Homeostasis in <i>Plasmodium falciparum</i> Infected Red Blood Cells

scientific article published on 05 January 2022

Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants

scientific article

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles.

scientific article

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

scientific article (publication date: 2 March 2017)

Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

scientific article published on 28 July 2016

Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria

scientific article published on 02 May 2015

Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions

scientific article published on 20 June 2019

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione

scientific article published on 19 December 2014

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

scientific article

Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines

scientific article published on 27 November 2012

Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes

scientific article published on 9 July 2008

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

scientific article published on 11 February 2008

Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry

scientific article

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

scientific article published on 20 October 2007

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

scientific article published on 9 July 2009

Stability of peroxide antimalarials in the presence of human hemoglobin

scientific article published on June 2009

Stable isotope labeled metabolomics improves identification of novel metabolites and pathways

scientific article published in August 2013

Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation

scientific article published on 25 September 2012

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks

scientific article

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

scientific article

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

scientific article

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics.

scientific article

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa

scientific article published on 03 October 2019

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study.

scientific article published on 16 April 2018

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

scientific article

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

scientific article published on 26 June 2020

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii

scientific article published on 11 January 2013

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

scientific article published on 20 August 2019

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

scientific article

Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction

scientific article

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

scientific article published on 30 March 2017

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei ⬇️

scientific article

Using the IDEOM Workflow for LCMS-Based Metabolomics Studies of Drug Mechanisms

scientific article published on 01 January 2020

What role can metabolomics play in the discovery and development of new medicines for infectious diseases?

article

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

scientific article

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