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List of works by Tom Owen-Hughes

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones

scientific article published on 18 July 2013

A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation

scientific article published on October 2009

A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

scientific article published on September 2011

ABF1-binding sites promote efficient global genome nucleotide excision repair

scientific article published on 6 November 2008

ATP-dependent looping of DNA by ISWI.

scientific article

ATRX: Put Me on Repeat ⬇️

scientific article published on October 29, 2010

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

scientific article published on 25 March 2014

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

scientific article published on 03 November 2021

Analysis of Transcription Factor-Mediated Remodeling of Nucleosomal Arrays in a Purified System

scientific article published on 01 July 1997

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes

scientific article

CENP-A confers a reduction in height on octameric nucleosomes

scientific article published on 5 May 2013

Chromatin remodelling comes into focus

scientific article published on 20 August 2020

DNA repair factor APLF is a histone chaperone

scientific article

De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases

scientific article published in July 2005

Deciphering Subunit-Specific Functions within SWI/SNF Complexes

scientific article published in February 2017

Direct observation of DNA distortion by the RSC complex

scientific article

Dynamic Properties of Nucleosomes during Thermal and ATP-Driven Mobilization ⬇️

scientific article published on November 1, 2003

EPR distance measurements in deuterated proteins

scientific article

Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

scientific article published on 10 August 2018

Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

scientific article published on October 2016

Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing

scientific article published on 22 April 2016

Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme

scientific article

Evolutionary insights into genome-wide nucleosome positioning

scientific article published on January 2012

FACT facilitates chromatin transcription by RNA polymerases I and III

scientific article

Generation of superhelical torsion by ATP-dependent chromatin remodeling activities

scientific article

High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division

scientific article

Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities

scientific article

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates.

scientific article published on 9 January 2017

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms

scientific article

Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability

scientific article published on 26 March 2007

Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

scientific article (publication date: 2 November 1990)

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

scientific article

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

scientific article published on 12 November 2018

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.

scientific article published on 31 May 2006

In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement

scientific article published in January 1996

Lighting up nucleosome spacing

scientific article published on 01 December 2006

Long distance PELDOR measurements on the histone core particle

scientific article

MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF.

scientific article

Making sense of transcribing chromatin

scientific article published on 10 March 2012

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

scientific article published on August 2013

Mechanisms for ATP-dependent chromatin remodelling

scientific article published on 01 April 2001

Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?

scientific article published on April 2004

Mechanisms for ATP‐dependent chromatin remodelling: the means to the end ⬇️

scientific article published on September 8, 2011

Mechanisms for nucleosome mobilization

scientific article (publication date: April 2003)

Micrococcal nuclease does not substantially bias nucleosome mapping

scientific article published on 30 January 2012

Modelling multi-protein complexes using PELDOR distance measurements for rigid body minimisation experiments using XPLOR-NIH.

scientific article published on 18 November 2014

Molecular biology. Breaking the silence

scientific article

Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions

scientific article

Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription

scientific article

Nucleosome mobilization catalysed by the yeast SWI/SNF complex

scientific article (publication date: 19 August 1999)

Nucleosome remodeling

Nucleosomes can invade DNA territories occupied by their neighbors

scientific article published in February 2009

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

scientific article

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

scientific article

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

scientific article

Probing the (H3-H4)2 histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling

scientific article

Pyrosequencing positions nucleosomes precisely

scientific article published on January 2007

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter

scientific article published on 26 May 2009

SWI/SNF stimulates the formation of disparate activator-nucleosome complexes but is partially redundant with cooperative binding

scientific article published in May 1997

Sin mutations alter inherent nucleosome mobility

scientific article

Site-specific attachment of reporter compounds to recombinant histones

scientific article published in January 2004

Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures

scientific article published on 25 August 2006

Snf2-family proteins: chromatin remodellers for any occasion ⬇️

scientific article published on August 20, 2011

Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment

scientific article published on 23 July 2015

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

scientific article

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.

scientific article published on 23 March 2017

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

scientific article published on 06 August 2018

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sulfyhydryl-Reactive Site-Directed Cross-Linking as a Method for Probing the Tetrameric Structure of Histones H3 and H4

scientific article published on 01 January 2012

The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors

scientific article

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

scientific article

The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression

scientific article

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

scientific article published on 7 May 2012

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.

scientific article published on 19 April 2011

The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme

scientific article

The TAF(II)250 subunit of TFIID has histone acetyltransferase activity

scientific article

The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression

scientific article (publication date: 16 October 1992)

The effect of DnaA protein levels and the rate of initiation at oriC on transcription originating in the ftsQ and ftsA genes: in vivo experiments

scientific article published on April 1989

The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3-H4 tetramers and Asf1-H3-H4 complexes

scientific article

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation

scientific article

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.

scientific article

The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement

scientific article

The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair

scientific article

Unlocking the nucleosome

scientific article

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