List of works - Roberto Civitelli

A Functional Assay to Assess Connexin 43-Mediated Cell-to-Cell Communication of Second Messengers in Cultured Bone Cells

scientific article published on January 2016

A dihydropyridine-sensitive calcium channel in rodent osteoblastic cells

scientific article published on 01 July 1989

A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate

scientific article

A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats

scientific article

ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells

scientific article

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

scientific article published on 01 May 2020

Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice

scientific article published in December 2006

Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells

scientific article published on 22 November 2002

Activation of the Ca2+ message system by parathyroid hormone is dependent on the cell cycle

scientific article published on 01 January 1994

Age-related decline of bone mass and intestinal calcium absorption in normal males.

scientific article published in September 1998

Alveolar bone measurement precision for phosphor-plate images

scientific article published on September 2009

An effective regimen of intranasal salmon calcitonin in early postmenopausal bone loss

scientific article

An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats

scientific article published on 01 March 1997

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).

scientific article published on June 2008

Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and O

article

Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

scientific article

Biological activity of different calcitonins in men

scientific article published on 01 January 1990

Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.

scientific article

Bone density in white Brazilian women: rapid loss at the time around the menopause

scientific article published on 01 March 1995

Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks

scientific article

Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series.

scientific article published on 23 June 2009

Bone turnover markers: understanding their value in clinical trials and clinical practice

scientific article published on 04 February 2009

Cadherin-mediated cell-cell adhesion and signaling in the skeleton

scientific article

Calcitonin and estrogens

scientific article

Calcium and vitamin D use among adults in periodontal disease maintenance programmes

scientific article

Casting new light on the sunshine vitamin

scientific article

Cell-cell communication in the osteoblast/osteocyte lineage.

scientific article published on 11 April 2008

Cell-cell signaling: broadening our view of the basic multicellular unit.

scientific article published on 27 July 2013

Cell-to-cell interactions in bone.

scientific article

Connexin 43 is Necessary for Murine Tendon Enthesis Formation and Response to Loading

scientific article published on 30 March 2020

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

scientific article

Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis

scientific article published in September 2011

Connexin43 modulation of osteoblast/osteocyte apoptosis: a potential therapeutic target?

scientific article published on November 2008

Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells

scientific article published on 19 April 2001

Connexins in the skeleton

scientific article published on 28 December 2015

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

scientific article

Cyclic AMP-dependent and calcium-dependent signals in parathyroid hormone function

scientific article published on 01 January 1990

Cyclic stretch enhances gap junctional communication between osteoblastic cells.

scientific article published in February 1998

Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.

scientific article published on April 2015

Depression, antidepressants, and bone health in older adults: a systematic review

scientific article

Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts

scientific article

Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells.

scientific article published on June 1991

Does interleukin-1 affect intracellular calcium in osteoblast-like cells (UMR-106)?

scientific article

Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL, independent of cell-cell adhesion

scientific article published on 8 August 2005

Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

scientific article published in September 1989

Effect of estrogen and calcitonin on vertebral bone density and vertebral height in osteoporotic women

scientific article

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

scientific article published on 04 September 2013

Estrogen action on the bone mass of postmenopausal women is dependent on body mass and initial bone density

scientific article published on 01 March 1995

Estrogen and/or calcium plus vitamin D increase mandibular bone mass.

scientific article published on June 2004

Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women.

scientific article

Estrogen status and bone mass in the premenopausal period: is osteoporosis a developmental disease?

scientific article

Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.

scientific article published on 2 August 2016

Gap junctions in skeletal development and function.

scientific article

Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription

scientific article

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

scientific article published on 02 November 2018

Genetic variation in the serotonin transporter and HTR1B receptor predicts reduced bone formation during serotonin reuptake inhibitor treatment in older adults

scientific article

Heterogeneous intracellular free calcium responses to parathyroid hormone correlate with morphology and receptor distribution in osteogenic sarcoma cells.

scientific article published on April 1992

Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation.

scientific article published on April 1998

In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics

scientific article (publication date: 1997)

Intercellular Calcium Signaling Occurs between Human Osteoblasts and Osteoclasts and Requires Activation of Osteoclast P2X7 Receptors

scientific article published on 27 December 2001

Intercellular Junctions and Cell–Cell Communication in the Skeletal System

scholarly article published 2008

Intravenous ibandronate injections in postmenopausal women with osteoporosis: One-year results from the dosing intravenous administration study

article

Ipriflavone does not alter bone apatite crystal structure in adult male rats

scientific article published on 01 December 1996

Ipriflavone improves bone density and biomechanical properties of adult male rat bones

scientific article published on 01 March 1995

Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43.

scientific article

Low-magnitude whole-body vibration does not enhance the anabolic skeletal effects of intermittent PTH in adult mice.

scientific article published on 8 November 2010

Maintaining the trust of physicians and the public in the medical literature: report of a task force on scientific publishing of clinical trials.

scientific article published in November 2007

Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes

scientific article published in June 1987

Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling

scientific article

Molecular mechanisms of osteoblast/osteocyte regulation by connexin43.

scientific article published on 11 June 2013

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.

scientific article

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.

scientific article

N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.

scientific article published on February 2015

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

scientific article

New Guidelines for Data Reporting and Statistical Analysis: Helping Authors With Transparency and Rigor in Research

scientific article published on 24 October 2019

Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells

scientific article

One-year effects of vitamin D and calcium supplementation on chronic periodontitis

scientific article

Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass

scientific article published in August 2005

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling

scientific journal article

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells.

scientific article

Osteoblast–osteoclast communication

article by Niklas Rye Jørgensen et al published October 1999 in Current opinion in orthopaedics

Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

scientific article published on 05 August 2020

Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone.

scientific article published on September 1989

Patient satisfaction in postmenopausal women treated with a weekly bisphosphonate transitioned to once-monthly ibandronate

scientific article published on July 2009

Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin

scientific article published on 07 October 2013

Relationship Between Low Bone Mineral Density and Fractures With Incident Cardiovascular Disease: A Systematic Review and Meta-Analysis

scientific article published on 31 January 2017

Relationships between clinical attachment level and spine and hip bone mineral density: data from healthy postmenopausal women

scientific article

Risedronate increases osteoblastic differentiation and function through connexin43.

scientific article published on 29 January 2013

Risedronate rapidly reduces the risk for nonvertebral fractures in women with postmenopausal osteoporosis

scientific article

Role of connexin43 in osteoblast response to physical load.

scientific article

Safety considerations with bisphosphonates for the treatment of osteoporosis.

scientific article published on January 2007

Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells.

scientific article published on June 1989

Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption

scientific article

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

article

Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells

scientific article published on 01 September 1994

Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes.

scientific article

Stimulation of human osteoblast differentiation and function by ipriflavone and its metabolites.

scientific article published on November 1994

Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells

scientific article

Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass

scientific article published on 01 March 1991

Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis.

scientific article published in June 2004

The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.

scientific article

The oxidative metabolism of estrogen modulates response to ERT/HRT in postmenopausal women

scientific article published in September 2004

The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy.

scientific article published in November 2002

The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity

scientific article published on June 2008

The role of vitamin D metabolites in the treatment of osteoporosis

scientific article published on 01 December 1995

Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice

scientific article

Toward personalized calcium and vitamin D supplementation

scientific article published on 22 March 2017

Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43 ⬇️

scientific article published on August 1, 1995

Use of intravenous bisphosphonates in osteoporosis

scientific article published on 01 March 2007

p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.

scientific article

List of works by Roberto Civitelli

A Functional Assay to Assess Connexin 43-Mediated Cell-to-Cell Communication of Second Messengers in Cultured Bone Cells

A dihydropyridine-sensitive calcium channel in rodent osteoblastic cells

A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate

A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats

ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice

Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells

Activation of the Ca2+ message system by parathyroid hormone is dependent on the cell cycle

Age-related decline of bone mass and intestinal calcium absorption in normal males.

Alveolar bone measurement precision for phosphor-plate images

An effective regimen of intranasal salmon calcitonin in early postmenopausal bone loss

An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).

Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and O

Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

Biological activity of different calcitonins in men

Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.

Bone density in white Brazilian women: rapid loss at the time around the menopause

Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks

Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series.

Bone turnover markers: understanding their value in clinical trials and clinical practice

Cadherin-mediated cell-cell adhesion and signaling in the skeleton

Calcitonin and estrogens

Calcium and vitamin D use among adults in periodontal disease maintenance programmes

Casting new light on the sunshine vitamin

Cell-cell communication in the osteoblast/osteocyte lineage.

Cell-cell signaling: broadening our view of the basic multicellular unit.

Cell-to-cell interactions in bone.

Connexin 43 is Necessary for Murine Tendon Enthesis Formation and Response to Loading

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis

Connexin43 modulation of osteoblast/osteocyte apoptosis: a potential therapeutic target?

Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells

Connexins in the skeleton

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

Cyclic AMP-dependent and calcium-dependent signals in parathyroid hormone function

Cyclic stretch enhances gap junctional communication between osteoblastic cells.

Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.

Depression, antidepressants, and bone health in older adults: a systematic review

Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts

Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells.

Does interleukin-1 affect intracellular calcium in osteoblast-like cells (UMR-106)?

Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL, independent of cell-cell adhesion

Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

Effect of estrogen and calcitonin on vertebral bone density and vertebral height in osteoporotic women

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

Estrogen action on the bone mass of postmenopausal women is dependent on body mass and initial bone density

Estrogen and/or calcium plus vitamin D increase mandibular bone mass.

Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women.

Estrogen status and bone mass in the premenopausal period: is osteoporosis a developmental disease?

Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.

Gap junctions in skeletal development and function.

Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

Genetic variation in the serotonin transporter and HTR1B receptor predicts reduced bone formation during serotonin reuptake inhibitor treatment in older adults

Heterogeneous intracellular free calcium responses to parathyroid hormone correlate with morphology and receptor distribution in osteogenic sarcoma cells.

Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation.

In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics

Intercellular Calcium Signaling Occurs between Human Osteoblasts and Osteoclasts and Requires Activation of Osteoclast P2X7 Receptors

Intercellular Junctions and Cell–Cell Communication in the Skeletal System

Intravenous ibandronate injections in postmenopausal women with osteoporosis: One-year results from the dosing intravenous administration study

Ipriflavone does not alter bone apatite crystal structure in adult male rats

Ipriflavone improves bone density and biomechanical properties of adult male rat bones

Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43.

Low-magnitude whole-body vibration does not enhance the anabolic skeletal effects of intermittent PTH in adult mice.

Maintaining the trust of physicians and the public in the medical literature: report of a task force on scientific publishing of clinical trials.

Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes

Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling

Molecular mechanisms of osteoblast/osteocyte regulation by connexin43.

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.

N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

New Guidelines for Data Reporting and Statistical Analysis: Helping Authors With Transparency and Rigor in Research

Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells

One-year effects of vitamin D and calcium supplementation on chronic periodontitis

Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling