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List of works by Rob N de Jong

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

scientific article published on 6 January 2016

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

scientific article published on July 2000

A simple, robust and highly efficient transient expression system for producing antibodies

scientific article published on 17 July 2013

Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.

scientific article

Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP.

scientific article

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.

scientific article

Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

scientific article published on 21 February 2019

Complement is activated by IgG hexamers assembled at the cell surface

scientific article

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

scientific article published on 25 September 2014

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

scientific article published on 18 September 2017

DNA binding properties of the adenovirus DNA replication priming protein pTP.

scientific article

Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent anti-tumor activity through DR5 agonism

scientific article published on 26 August 2020

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

scientific article

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

scientific article published on 6 April 2017

Enzyme free cloning for high throughput gene cloning and expression

scientific article published on 01 December 2006

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

scientific article published on 19 September 2006

Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.

scientific article

Functional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies

scientific article

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

scientific article published on 03 January 2014

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

scientific article

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.

scientific article published in April 2019

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

scientific article published on 13 April 2017

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

scientific article published on 17 November 2017

Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication.

scientific article

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

scientific article published on 15 June 2016

NMR characterization of foldedness for the production of E3 RING domains

scientific article published on 2 August 2010

NMR in the SPINE Structural Proteomics project.

scientific article

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells

scientific article published on 01 January 2020

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.

scientific article

Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces

scientific article

Relaxed template specificity in fowl adenovirus 1 DNA replication initiation

scientific article published in March 2006

Solution structure of the human ubiquitin-specific protease 15 DUSP domain

scientific article

Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli

scientific article published on 25 September 2006

Structure and DNA binding of the human Rtf1 Plus3 domain

scientific article

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

scientific article

Symmetry and asymmetry of the RING-RING dimer of Rad18

scientific article

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

scientific article published on 27 May 2015

The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation inBacillus

scientific article published in Journal of Biological Chemistry

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

scientific article published on 10 October 2017

Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces

scientific article published on 11 June 2019

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