List of works by Patrick C Gedeon

A rationally designed fully human EGFRvIII:CD3-targeted bispecific antibody redirects human T cells to treat patient-derived intracerebral malignant glioma.

scientific article published on 27 April 2018

Accelerated molecular dynamics and protein conformational change: a theoretical and practical guide using a membrane embedded model neurotransmitter transporter

scientific article

An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma.

scientific article

Antibody-based immunotherapy for malignant glioma

scientific article

Are BiTEs the "missing link" in cancer therapy?

scientific article

Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook

scientific article published on 11 September 2020

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

scientific article

Epidermal growth factor receptor and variant III targeted immunotherapy.

scientific article

GLP toxicology study of a fully-human T cell redirecting CD3:EGFRvIII binding immunotherapeutic bispecific antibody

scientific article published on 31 July 2020

Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody

scientific article published on September 2013

Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.

scientific article published on 17 September 2013

LeuT conformational sampling utilizing accelerated molecular dynamics and principal component analysis

scientific article

Molecular dynamics of leucine and dopamine transporter proteins in a model cell membrane lipid bilayer

scientific article published in March 2010

Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts

scientific article published on 13 November 2018

Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis.

scientific article published on 24 June 2013

Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody

scientific article published on 22 October 2013

Rindopepimut: anti-EGFRvIII peptide vaccine, oncolytic

scientific article published on March 2013

Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysis

scientific article

Structure and Dynamics Study of LeuT Using the Markov State Model and Perturbation Response Scanning Reveals Distinct Ion Induced Conformational States

scientific article published on 16 June 2016

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.

scientific article published on 17 December 2012

Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.

scientific article

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