List of works - George A O'Doherty

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis

scientific article

A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity

scientific article published on 19 October 2010

A general approach to anionic acid-labile surfactants with tunable properties

scientific article published on September 2010

A novel use of gentamicin in the ROS-mediated sensitization of NCI-H460 lung cancer cells to various anticancer agents

scientific article

A palladium-catalyzed glycosylation reaction: the de novo synthesis of natural and unnatural glycosides

scientific article

A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation

scientific article published on September 2006

An enantioselective synthesis of benzylidene-protected syn-3,5-dihydroxy carboxylate esters via osmium, palladium, and base catalysis

scientific article published on 01 April 2001

An enantioselective synthesis of cryptocarya diacetate

scientific article published on 01 August 2001

An enantioselective synthesis of tarchonanthuslactone

scientific article

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells.

scientific article published in June 2017

Approach to the Synthesis of the C-C and C-C portion of Leucascandrolide A

scientific article published on 12 July 2016

Asymmetric Aminohydroxylation of Vinylfuran

scientific article published on 01 April 1999

Biosynthesis and Total Synthesis Studies on The Jadomycin Family of Natural Products

scientific article published on April 2012

C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity

scientific article

C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity

scientific article

Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases

scientific article published on 10 April 2018

Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study

scientific article published on 24 October 2019

Correction: The asymmetric syntheses of cryptocaryols A and B

scientific article published on 01 June 2018

Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

scientific article

DE NOVO ASYMMETRIC APPROACH TO THE DISACCHARIDE PORTION OF SCH-47554.

scientific article published on 15 September 2010

De Novo Asymmetric Syntheses of (+)-Goniothalamin, (+)-Goniothalamin oxide and 7,8-Bis-epi-Goniothalamin using Asymmetric Allylations

scientific article published on June 2009

De Novo Asymmetric Syntheses of d-, l- and 8-epi-Swainsonine

scientific article

De Novo Asymmetric Synthesis and Biological Analysis of the Daumone Pheromones in Caenorhabditis elegans and in the Soybean Cyst Nematode Heterodera glycines.

scientific article published on 16 March 2016

De Novo Asymmetric Synthesis of (+)-Monanchorin.

scientific article published on 13 October 2015

De Novo Asymmetric Synthesis of Avocadyne, Avocadene, and Avocadane Stereoisomers

scientific article published on 07 November 2019

De Novo Asymmetric Synthesis of Phoracantholide J

scientific article published on 16 September 2016

De Novo Asymmetric Synthesis of a 6-O-Methyl-D-glycero-L-gluco-heptopyranose-Derived Thioglycoside for the Preparation of Campylobacter jejuni NCTC11168 Capsular Polysaccharide Fragments.

scientific article published on 16 March 2016

De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin

scientific article published on 6 March 2007

De novo asymmetric syntheses of C-4-substituted sugars via an iterative dihydroxylation strategy

scientific article

De novo asymmetric syntheses of D- and L-talose via an iterative dihydroxylation of dienoates

scientific article

De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

scientific article published on October 2006

De novo asymmetric syntheses of muricatacin and its analogues via dihydroxylation of dienoates

scientific article

De novo asymmetric synthesis and biological evaluation of the trisaccharide portion of PI-080 and vineomycin B2.

scientific article published on 12 September 2008

De novo asymmetric synthesis of 8a-epi-swainsonine

scientific article

De novo asymmetric synthesis of D- and L-swainsonine

scientific article published on April 2006

De novo asymmetric synthesis of all-D-, all-L-, and D-/L-oligosaccharides using atom-less protecting groups

scientific article published on 16 July 2012

De novo asymmetric synthesis of an alpha-6-deoxyaltropyranoside as well as its 2-/3-deoxy and 2,3-dideoxy congeners

scientific article published in August 2009

De novo asymmetric synthesis of anamarine and its analogues

scientific article

De novo asymmetric synthesis of anthrax tetrasaccharide and related tetrasaccharide

scientific article

De novo asymmetric synthesis of cladospolide B-D: structural reassignment of cladospolide D via the synthesis of its enantiomer

scientific article published on 01 March 2009

De novo asymmetric synthesis of fridamycin E.

scientific article published on 22 November 2011

De novo asymmetric synthesis of homoadenosine via a palladium-catalyzed N-glycosylation

scientific article

De novo asymmetric synthesis of milbemycin beta3 via an iterative asymmetric hydration approach

scientific article published in August 2006

De novo asymmetric synthesis of oligo-rhamno di- and tri-saccharides related to the anthrax tetrasaccharide

scientific article

De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction

scientific article

De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation.

scientific article published in June 2014

De novo asymmetric synthesis of the pyranoses: from monosaccharides to oligosaccharides.

scientific article published on January 2013

De novo enantioselective syntheses of galacto-sugars and deoxy sugars via the iterative dihydroxylation of dienoate

scientific article published on 01 February 2005

De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence

scientific article

De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates

scientific article published on 3 July 2007

De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.

scientific article published on 5 November 2014

De novo synthesis of 2-substituted syn-1,3-diols via an iterative asymmetric hydration strategy

scientific article published on September 2006

De novo synthesis of deoxy sugar via a Wharton rearrangement

scientific article

De novo synthesis of natural products via the asymmetric hydration of polyenes

scientific article published on 11 May 2011

De novo synthesis of oligosaccharides using a palladium-catalyzed glycosylation reaction

scientific article published in March 2004

De novo synthesis of the trisaccharide subunit of landomycins A and E

scientific article published on 08 May 2008

Digitoxin analogues with improved anticytomegalovirus activity

scientific article published on 25 January 2014

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

journal article published in 2012

Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel

scientific article

Enantioselective syntheses of colletodiol, colletol, and grahamimycin A

scientific article published on 01 December 2002

Enantioselective syntheses of cryptocarya triacetate, cryptocaryolone, and cryptocaryolone diacetate

scientific article published on 01 May 2003

Enantioselective syntheses of isoaltholactone, 3-epi-altholactone, and 5-hydroxygoniothalamin

scientific article published on 01 September 2000

Enantioselective synthesis of 10-epi-anamarine via an iterative dihydroxylation sequence

scientific article published on 01 March 2005

Enantioselective synthesis of 2-deoxy- and 2,3-dideoxyhexoses

scientific article published in May 2002

Enantioselective synthesis of N-Cbz-protected 6-amino-6-deoxymannose, -talose, and -gulose

scientific article published on 01 November 2001

Enantioselective synthesis of the papulacandin ring system: conversion of the mannose diastereoisomer into a glucose stereoisomer

scientific article published on 01 December 2000

Enzymatic incorporation of orthogonally reactive prenylazide groups into peptides using geranylazide diphosphate via protein farnesyltransferase: implications for selective protein labeling

scientific article published in January 2005

Flexible Acyclic Polyol-Chloride Anion Complexes and Their Characterization by Photoelectron Spectroscopy and Variable Temperature Binding Constant Determinations

scientific article published on 24 February 2016

Formal total synthesis of RK-397 via an asymmetric hydration and iterative allylation strategy

scientific article published on 13 June 2008

Hydrogen-bond networks: strengths of different types of hydrogen bonds and an alternative to the low barrier hydrogen-bond proposal.

scientific article

Identifying requirements for RSK2 specific inhibitors

scientific article published on 01 December 2021

Improving the affinity of SL0101 for RSK using structure-based design.

scientific article

Merremoside D: de novo synthesis of the purported structure, NMR analysis, and comparison of spectral data

scientific article

Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx

scientific article published on April 2008

Modulators of Na/K-ATPase: a patent review

scientific article published on 17 May 2012

Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation

journal article published in 2014

Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides.

scientific article

Regioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101

scientific article published on 03 February 2020

Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway

scientific article published on 19 July 2012

Sharpless asymmetric dihydroxylation of 5-aryl-2-vinylfurans: application to the synthesis of the spiroketal moiety of papulacandin D

scientific article published on 01 March 2000

Site-Specific Reversible Protein and Peptide Modification: Transglutaminase-Catalyzed Glutamine Conjugation and Bioorthogonal Light-Mediated Removal

scientific article published on 15 April 2019

Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin

scientific article published on 21 February 2018

Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell

scientific article

Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.

scientific article

Structure Activity Relationship Study of the Cleistriosides and Cleistetrosides for Antibacterial/Anticancer Activity.

scientific article published on 30 October 2012

Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity.

scientific article published on August 2014

Syntheses of D- and L-Mannose, Gulose, and Talose via Diastereoselective and Enantioselective Dihydroxylation Reactions

scientific article published on 01 April 1999

Syntheses of four D- and L-hexoses via diastereoselective and enantioselective dihydroxylation reactions

scientific article published on 01 August 2000

Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols

scientific article published on 27 February 2020

Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents

scientific article

Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.

scientific article published on 26 November 2014

Synthesis and biological study of the phomopsolide and phomopsolidone natural products

scientific article published on 07 October 2020

Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

scientific article published on 08 May 2019

Synthesis of D- and L-deoxymannojirimycin via an asymmetric aminohydroxylation of vinylfuran

scientific article published on 01 February 2001

Synthesis of Dehydro-Dephospho-Fostriecin and Formal Total Synthesis of Fostriecin

scientific article published on 04 October 2019

Synthesis of SL0101 carbasugar analogues: carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformations

scientific article published on July 2010

Synthesis of aza-analogues of the glycosylated tyrosine portion of mannopeptimycin-E.

scientific article published on 26 May 2007

Synthesis of carbasugar C-1 phosphates via Pd-catalyzed cyclopropanol ring opening

scientific article published on 18 July 2008

Synthesis of several cleistrioside and cleistetroside natural products via a divergent de novo asymmetric approach

scientific article published on November 2010

Synthetic studies toward mannopeptimycin-E: synthesis of the O-linked tyrosine 1,4-alpha,alpha-manno,manno-pyranosyl pyranoside

scientific article published in April 2006

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxy

scientific article published on 01 March 2020

The asymmetric syntheses of cryptocaryols A and B.

scientific article published on 16 March 2018

Total Synthesis of Fostriecin: Via a Regio- and Stereoselective Polyene Hydration, Oxidation, and Hydroboration Sequence ⬇️

scientific article published on September 3, 2010

Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B.

scientific article published on December 2010

Total synthesis of tetrahydrolipstatin and stereoisomers via a highly regio- and diastereoselective carbonylation of epoxyhomoallylic alcohols.

scientific article published on 18 July 2014

de novo asymmetric synthesis of daumone via a palladium-catalyzed glycosylation

scientific article published on 01 September 2005

List of works by George A O'Doherty

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis

A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity

A general approach to anionic acid-labile surfactants with tunable properties

A novel use of gentamicin in the ROS-mediated sensitization of NCI-H460 lung cancer cells to various anticancer agents

A palladium-catalyzed glycosylation reaction: the de novo synthesis of natural and unnatural glycosides

A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation

An enantioselective synthesis of benzylidene-protected syn-3,5-dihydroxy carboxylate esters via osmium, palladium, and base catalysis

An enantioselective synthesis of cryptocarya diacetate

An enantioselective synthesis of tarchonanthuslactone

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells.

Approach to the Synthesis of the C-C and C-C portion of Leucascandrolide A

Asymmetric Aminohydroxylation of Vinylfuran

Biosynthesis and Total Synthesis Studies on The Jadomycin Family of Natural Products

C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity

C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity

Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases

Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study

Correction: The asymmetric syntheses of cryptocaryols A and B

Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

DE NOVO ASYMMETRIC APPROACH TO THE DISACCHARIDE PORTION OF SCH-47554.

De Novo Asymmetric Syntheses of (+)-Goniothalamin, (+)-Goniothalamin oxide and 7,8-Bis-epi-Goniothalamin using Asymmetric Allylations

De Novo Asymmetric Syntheses of d-, l- and 8-epi-Swainsonine

De Novo Asymmetric Synthesis and Biological Analysis of the Daumone Pheromones in Caenorhabditis elegans and in the Soybean Cyst Nematode Heterodera glycines.

De Novo Asymmetric Synthesis of (+)-Monanchorin.

De Novo Asymmetric Synthesis of Avocadyne, Avocadene, and Avocadane Stereoisomers

De Novo Asymmetric Synthesis of Phoracantholide J

De Novo Asymmetric Synthesis of a 6-O-Methyl-D-glycero-L-gluco-heptopyranose-Derived Thioglycoside for the Preparation of Campylobacter jejuni NCTC11168 Capsular Polysaccharide Fragments.

De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin

De novo asymmetric syntheses of C-4-substituted sugars via an iterative dihydroxylation strategy

De novo asymmetric syntheses of D- and L-talose via an iterative dihydroxylation of dienoates

De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

De novo asymmetric syntheses of muricatacin and its analogues via dihydroxylation of dienoates

De novo asymmetric synthesis and biological evaluation of the trisaccharide portion of PI-080 and vineomycin B2.

De novo asymmetric synthesis of 8a-epi-swainsonine

De novo asymmetric synthesis of D- and L-swainsonine

De novo asymmetric synthesis of all-D-, all-L-, and D-/L-oligosaccharides using atom-less protecting groups

De novo asymmetric synthesis of an alpha-6-deoxyaltropyranoside as well as its 2-/3-deoxy and 2,3-dideoxy congeners

De novo asymmetric synthesis of anamarine and its analogues

De novo asymmetric synthesis of anthrax tetrasaccharide and related tetrasaccharide

De novo asymmetric synthesis of cladospolide B-D: structural reassignment of cladospolide D via the synthesis of its enantiomer

De novo asymmetric synthesis of fridamycin E.

De novo asymmetric synthesis of homoadenosine via a palladium-catalyzed N-glycosylation

De novo asymmetric synthesis of milbemycin beta3 via an iterative asymmetric hydration approach

De novo asymmetric synthesis of oligo-rhamno di- and tri-saccharides related to the anthrax tetrasaccharide

De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction

De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation.

De novo asymmetric synthesis of the pyranoses: from monosaccharides to oligosaccharides.

De novo enantioselective syntheses of galacto-sugars and deoxy sugars via the iterative dihydroxylation of dienoate

De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence

De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates

De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.

De novo synthesis of 2-substituted syn-1,3-diols via an iterative asymmetric hydration strategy

De novo synthesis of deoxy sugar via a Wharton rearrangement

De novo synthesis of natural products via the asymmetric hydration of polyenes

De novo synthesis of oligosaccharides using a palladium-catalyzed glycosylation reaction

De novo synthesis of the trisaccharide subunit of landomycins A and E

Digitoxin analogues with improved anticytomegalovirus activity

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel

Enantioselective syntheses of colletodiol, colletol, and grahamimycin A

Enantioselective syntheses of cryptocarya triacetate, cryptocaryolone, and cryptocaryolone diacetate

Enantioselective syntheses of isoaltholactone, 3-epi-altholactone, and 5-hydroxygoniothalamin

Enantioselective synthesis of 10-epi-anamarine via an iterative dihydroxylation sequence

Enantioselective synthesis of 2-deoxy- and 2,3-dideoxyhexoses

Enantioselective synthesis of N-Cbz-protected 6-amino-6-deoxymannose, -talose, and -gulose

Enantioselective synthesis of the papulacandin ring system: conversion of the mannose diastereoisomer into a glucose stereoisomer

Enzymatic incorporation of orthogonally reactive prenylazide groups into peptides using geranylazide diphosphate via protein farnesyltransferase: implications for selective protein labeling

Flexible Acyclic Polyol-Chloride Anion Complexes and Their Characterization by Photoelectron Spectroscopy and Variable Temperature Binding Constant Determinations

Formal total synthesis of RK-397 via an asymmetric hydration and iterative allylation strategy

Hydrogen-bond networks: strengths of different types of hydrogen bonds and an alternative to the low barrier hydrogen-bond proposal.

Identifying requirements for RSK2 specific inhibitors

Improving the affinity of SL0101 for RSK using structure-based design.

Merremoside D: de novo synthesis of the purported structure, NMR analysis, and comparison of spectral data

Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx

Modulators of Na/K-ATPase: a patent review

Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation

Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides.

Regioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101

Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway