List of works - David Brough

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

scientific article published on 10 August 2007

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

scientific article

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage

scientific article published on 31 August 2015

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway

scientific article published on 10 September 2013

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility

scientific article published on December 2005

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

scientific article published on 4 September 2017

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

scientific article

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

scientific article published on 03 November 2020

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

scientific article published on 6 April 2016

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

scientific article published in March 2003

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

scientific article published on 6 February 2007

Caspase-1: is IL-1 just the tip of the ICEberg?

scientific article published on 05 July 2012

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

article

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

article published in the Proceedings of the National Academy of Sciences of the United States of America

Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study (Preprint)

preprint

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome

scientific article

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

scientific article published on 13 January 2018

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

scientific article published on 3 December 2012

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

scientific article published on 4 April 2018

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

scientific article published on August 2009

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

scientific article

Extracellular ATP and P2X7 receptors in neurodegeneration

scientific article

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

scientific article

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data

scientific article published on 13 May 2020

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

scientific article published on 14 February 2020

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture

scientific article published on 23 May 2020

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data

article

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

scientific article published on 04 October 2019

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

scientific article

Inflammasomes as therapeutic targets for Alzheimer's disease

scientific article

Inflammasomes link vascular disease with neuroinflammation and brain disorders

scientific article

Inhibiting the Inflammasome: A Chemical Perspective.

scientific article published on 30 September 2015

Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes

scientific article

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

scientific article published on 20 September 2020

Interleukin-1 as a pharmacological target in acute brain injury

scientific article published on 12 June 2015

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

scientific article published on 31 May 2012

Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta

scientific article

Interleukin-1α and brain inflammation

scientific article published on 23 April 2015

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

scientific article

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

scientific article

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

scientific article published on 20 November 2020

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

scientific article published on 04 November 2020

Mechanisms of regulation for interleukin-1beta in neurodegenerative disease

scientific article published on 12 March 2007

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

scientific article published on 13 February 2013

Mini-symposium: Role of the inflammasome in brain pathogenesis: a potential therapeutic target? - introduction

scientific article published on 23 December 2016

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids

scientific article published on 28 June 2005

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

scientific article

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro

scientific journal article

Novel perspectives on non-canonical inflammasome activation

scientific article

Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation

scientific article published on November 2009

Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide

scientific article

P2X7 receptor-dependent tuning of gut epithelial responses to infection

scientific article

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

scientific article published on 9 June 2015

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

scientific article published on February 2009

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways

scientific article published on September 2015

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

scientific article published on 12 November 2001

Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism

scientific article published in February 2002

Redefining the ancestral origins of the interleukin-1 superfamily.

scientific article published on 20 March 2018

Regulation of interleukin-1 in acute brain injury

scientific article published on 23 July 2011

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death

scientific article published on 30 April 2014

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo

scientific article published in March 2003

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming

scientific article published on 20 November 2018

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

scientific article

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

scientific article (publication date: August 2014)

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import

scientific article published on 7 October 2008

The role of inflammation and interleukin-1 in acute cerebrovascular disease

scientific article

The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate

scientific article published on August 2005

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

scientific article

Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo

scientific article published on 24 October 2011

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

scholarly article by Pablo Palazon-Riquelme published in October 2018

Unconventional Pathways of Secretion Contribute to Inflammation.

scientific article published on 5 January 2017

Understanding the mechanism of IL-1β secretion

scientific article published on August 2011

Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation

scientific article published on 17 February 2021

Zinc depletion regulates the processing and secretion of IL-1β.

scientific article published on 30 January 2014

List of works by David Brough

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Caspase-1: is IL-1 just the tip of the ICEberg?

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study (Preprint)

Consensus guidelines for the detection of immunogenic cell death

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Extracellular ATP and P2X7 receptors in neurodegeneration

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

Inflammasomes as therapeutic targets for Alzheimer's disease

Inflammasomes link vascular disease with neuroinflammation and brain disorders

Inhibiting the Inflammasome: A Chemical Perspective.

Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

Interleukin-1 as a pharmacological target in acute brain injury

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta

Interleukin-1α and brain inflammation

Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Mechanisms of regulation for interleukin-1beta in neurodegenerative disease

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

Mini-symposium: Role of the inflammasome in brain pathogenesis: a potential therapeutic target? - introduction

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro

Novel perspectives on non-canonical inflammasome activation

Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation

Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide

P2X7 receptor-dependent tuning of gut epithelial responses to infection

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism

Redefining the ancestral origins of the interleukin-1 superfamily.

Regulation of interleukin-1 in acute brain injury

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import

The role of inflammation and interleukin-1 in acute cerebrovascular disease

The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

Unconventional Pathways of Secretion Contribute to Inflammation.

Understanding the mechanism of IL-1β secretion

Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation

Zinc depletion regulates the processing and secretion of IL-1β.