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List of works by Gergely L Lukacs

(+)-Cyanidanol-3 prevents the functional deterioration of rat liver mitochondria induced by Fe2+ ions

scientific article published on 01 July 1986

A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death

scientific article published on 02 September 2016

A human epithelium-specific vector optimized in rat pneumocytes for lung gene therapy

scientific article published on August 2000

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

scientific article

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

scientific article published on 27 August 2020

Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas

scientific article published on 11 December 2011

Analysis of differential lipofection efficiency in primary and established myoblasts

scientific article published on 01 February 2002

Analysis of endocytic trafficking by single-cell fluorescence ratio imaging

scientific article published on September 2008

Antibodies for CFTR studies.

scientific article published in August 2004

Antifungal activity of statins and their interaction with amphotericin B against clinically important Zygomycetes

scientific article published on September 2010

Ba2+ ions inhibit the release of Ca2+ ions from rat liver mitochondria

scientific article published on 01 September 1985

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

scientific article published on June 1987

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

Biochemical methods to assess CFTR expression and membrane localization

article

C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation

scientific article published on July 1999

CFTR Folding Consortium: methods available for studies of CFTR folding and correction

scientific article published on January 2011

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

scientific article published on January 2006

CFTR folding and maturation in cells

scientific article published on January 2002

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

scientific article published on 09 February 2016

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

scientific article published on 3 December 2011

Cell surface dynamics of CFTR: the ins and outs.

scientific article published on 19 January 2007

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop

scientific article

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

scientific article published in March 2018

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

scientific article published on 30 August 2017

Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator.

scientific article

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.

scientific article

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

scientific article

Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation

scientific article published on December 1997

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells

scientific article published on 29 November 2004

Cooperative assembly and misfolding of CFTR domains in vivo.

scientific article published on 28 January 2009

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

scientific article published on January 2012

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

scientific article

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

scientific article published on April 2004

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis

scientific article

Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator

scientific article

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells.

scientific article

Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator

scientific article published on 10 November 2004

Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak"

scientific article published on 01 December 1991

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator

scientific article

Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways ⬇️

scientific article published on December 23, 1997

Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers

scientific article published on 01 January 2014

Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis

scientific article published on 01 January 2019

Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

scientific article

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

scientific article

Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoform

scientific article published on 01 February 1996

Dominant and recessive distal renal tubular acidosis mutations of kidney anion exchanger 1 induce distinct trafficking defects in MDCK cells

scientific article published on February 2006

Effect of inositol 1,4,5-trisphosphate and GTP on calcium release from pituitary microsomes

scientific article

Endocytic sorting of CFTR variants monitored by single-cell fluorescence ratiometric image analysis (FRIA) in living cells.

scientific article published on January 2011

Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway.

scientific article published in August 1998

Epithelial Anion Transport as Modulator of Chemokine Signaling

scientific article

Extracellular oxidation in Cystic Fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity

scientific article published on 14 December 2017

Fixing cystic fibrosis by correcting CFTR domain assembly

scientific article published on October 2012

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

scientific article published on February 2016

Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells

scientific article published on February 1997

In vitro interactions between primycin and different statins in their effects against some clinically important fungi.

scientific article published on 29 October 2009

Ins and outs of AlphaFold2 transmembrane protein structure predictions

scientific article published on 15 January 2022

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.

scientific article published on 20 June 2013

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

scientific article published on 7 October 2015

Intracellular barriers to non-viral gene transfer.

scientific article

Intracellular routing of plasmid DNA during non-viral gene transfer.

scientific article

Introduction to Section III: Biochemical Methods to Study CFTR Protein

article

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking.

scientific article

Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

scientific article published on 01 March 1998

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2.

scientific article published on December 1987

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

scientific article published on 12 May 2013

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

scientific article published in April 1999

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

scientific article

Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells

scientific article published on March 2006

Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer

scientific article

Mutation-specific downregulation of CFTR2 variants by gating potentiators

scientific article published on 4 October 2017

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

scientific article published on 30 October 2019

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

scientific article published on March 2009

Nanomechanical sensors for single microbial cell growth monitoring

scientific article

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

scientific article published on 27 June 2003

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

scientific article

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation

scientific article

Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells

scientific article published on 3 October 2005

PINK1 autophosphorylation is required for ubiquitin recognition

scientific article published on 23 February 2018

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca2+ in fura-2-loaded heart mitochondria

scientific article published on 01 February 1988

Peripheral protein quality control removes unfolded CFTR from the plasma membrane

scientific article published on July 2010

Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages

scientific article published on 01 December 1990

Pharmacologic approaches to correcting the basic defect in cystic fibrosis

scientific article published on 01 October 2003

Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana) ⬇️

scientific article published on January 1, 1991

Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia

scientific article published on 03 September 2019

Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway

scientific article published on 23 June 2008

Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

scientific article

Prevalence of postweaning multisystemic wasting syndrome in pigs sired by 13 Hungarian Landrace boars

scientific article

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

scientific article

Protein homeostasis at the plasma membrane

scientific article

Protein quality control at the plasma membrane

scientific article published on 14 May 2011

Proteomics techniques for cystic fibrosis research.

scientific article published in August 2004

Proteostasis: Chaperoning for hearing loss

scientific article published in May 2016

Proton conductance of the plasma membrane: properties, regulation, and functional role

scientific article published on July 1993

Quality control for unfolded proteins at the plasma membrane

scientific article

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

scientific article published on 27 May 2016

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

scientific article

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

scientific article

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress

scientific article published on 01 October 1995

Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles

scientific article published on 06 May 2009

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

scientific article

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR

scientific article published on 06 March 2020

Single Cell Fluorescence Ratio Image Analysis for Studying ESCRT Function in Receptor Trafficking

scientific article published on 01 January 2019

Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins

scientific article

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway

scientific article published on 14 November 2012

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

scientific article

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

scientific article published on July 2014

Structure-guided combination therapy to potently improve the function of mutant CFTRs

article

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

scientific article

The Ba2+ sensitivity of the Na+-induced Ca2+ efflux in heart mitochondria: the site of inhibitory action

scientific article published on 01 June 1986

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

scientific article

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

scientific article

The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells

scientific article published in August 1991

The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH

scientific article published on 01 July 1992

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

scientific article

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells

scientific article published on 01 October 1993

The effect of inositol 1,4,5-trisphosphate and GTP on calcium release from rat liver microsomes

scientific article published on 01 November 1987

The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomes

scientific article published on 01 January 1998

The first independent study on the complex trial protocol version of the P300-based concealed information test: Corroboration of previous findings and highlights on vulnerabilities

scientific article published on 14 October 2016

The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia

scientific article published on 21 March 2003

Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions

scientific article

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

scientific article published on 15 May 2019

Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells

scientific article published on July 1998

Ubiquitin-dependent sorting in endocytosis

scientific article published on January 2014

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

scientific article published on 23 October 2013

V-ATPases in phagocytic cells

scientific article published on November 1, 1992

[The role of preoperative investigation with 18-FDG-PET/CT in primary operable breast cancer].

scientific article

hERG quality control and the long QT syndrome

scientific article published on 31 December 2015

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

scientific article published on 13 March 2018

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