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List of works by Stefan N Constantinescu

A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.

scientific article

A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms.

scientific article

A Type I Interferon Signaling Factor, ISF21, Encoded on Chromosome 21 Is Distinct from Receptor Components and Their Down-regulation and Is Necessary for Transcriptional Activation of Interferon-regulated Genes

article

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

scholarly article

A new era for small molecule screening: from new targets, such as JAK2 V617F, to complex cellular screens

scientific article

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling

scientific article

A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation

scientific article

A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases

scientific article published in January 2005

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

scientific article (publication date: 28 April 2005)

Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers

scientific article published on August 2013

Activating mutations in human acute megakaryoblastic leukemia.

scientific article

Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

scientific article published on November 2003

Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers

scientific article

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

scientific article published on 16 January 2008

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

scientific article published on 20 July 2009

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. ⬇️

scientific article published on 25 October 2005

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

scientific article published on 10 November 2016

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

scientific article

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

scientific article published on 28 September 2020

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

scientific article published on 22 March 2019

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

scientific article published on 25 November 2015

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

scientific article

Complementation of the interferon alpha response in resistant cells by expression of the cloned subunit of the interferon alpha receptor. A central role of this subunit in interferon alpha signaling.

scientific article published on April 1994

Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production

scientific article published on 23 January 2014

Contribution of Kunitz Protease Inhibitor and Transmembrane Domains to Amyloid Precursor Protein Homodimerization

scientific article published on 10 February 2012

Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors

scientific article

Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia

scientific article

Cytokine receptor signal transduction and the control of hematopoietic cell development

scientific article published on January 1996

Cytokines in hematopoiesis: specificity and redundancy in receptor function

scientific article published on 01 January 1998

Development of human protein reference database as an initial platform for approaching systems biology in humans

scientific article (publication date: October 2003)

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

scientific article published on 22 June 2020

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

scientific article published on 26 January 2005

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

scientific article published on 12 September 2014

Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry

scientific article published on 31 December 2013

Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities

scientific article

Effects of erythropoietin receptors and erythropoiesis-stimulating agents on disease progression in cancer.

scientific article published on 6 March 2012

Effects of protein kinase C inhibitors on viral entry and infectivity

scientific article published on 01 November 1991

Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex

scientific article published on November 1995

Extracellular domain N-glycosylation controls human thrombopoietin receptor cell surface levels

scientific article published on 11 November 2011

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

scientific article published on 30 May 2013

Gathering support for critical mass: interleukin 4 receptor signaling requires clustering in endosomes

scientific article

Generation of mammalian cells stably expressing multiple genes at predetermined levels.

scientific article

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

scientific article published on 07 January 2014

Germline counterparts of oncogenic mutations: who gives a JAK?.

scientific article published on June 2013

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

scientific article published on 10 May 2016

HIV-1 infection in Romanian children

article

Helix packing and orientation in the transmembrane dimer of gp55-P of the spleen focus forming virus

scientific article

High-throughput gateway bicistronic retroviral vectors for stable expression in mammalian cells: exploring the biologic effects of STAT5 overexpression

scientific article

His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor

scientific article published on December 2015

Human renal cancers resistant to IFN's antiproliferative action exhibit sensitivity to IFN's gene-inducing and antiviral actions

scientific article published on 01 November 1996

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

scientific article published on 27 March 2013

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

article

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.

scientific article

Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility

scientific article published on 25 September 2015

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

scientific article published on May 2006

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

scientific article

Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

scientific article published on 26 June 2002

Introduction to ‘A special spotlight review series on BCR–ABL-negative myeloproliferative neoplasms’

article

JAK kinases overexpression promotes in vitro cell transformation

scientific article

JAK/STAT signaling in hematological malignancies.

scientific article

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

scientific article published on 19 October 2005

JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

scientific article

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

scientific article

JAK2, the JAK2 V617F mutant and cytokine receptors.

scientific article

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

scientific article

Janus kinases affect thrombopoietin receptor cell surface localization and stability

scientific article

Journal of Cellular and Molecular Medicine: the Future

scientific article published on February 2017

Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development

scientific article published on 30 August 2019

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity

scientific article published on 04 March 2009

Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells

scientific article published on 11 August 2005

Mining for JAK-STAT mutations in cancer

scientific article published on March 2008

Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3

scientific journal article

Mpl and thrombocytosis: levels matter

scientific article published on 01 February 2009

Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK.

scientific article

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

scientific article published on 15 May 2014

Neurobiology of vascular dementia

scientific article

New mutations and pathogenesis of myeloproliferative neoplasms.

scientific article published on 07 June 2011

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

scientific article published in May 2014

Novel head-to-head gene fusion of MLL with ZC3H13 in a JAK2 V617F-positive patient with essential thrombocythemia without blast cells

article

Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations

scientific article published on 14 September 2015

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors

scientific article

Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms

scientific article published on 06 October 2015

Orientation-specific signalling by thrombopoietin receptor dimers.

scientific article published on 2 September 2011

PDGFRB mutants found in patients with familial infantile myofibromatosis or overgrowth syndrome are oncogenic and sensitive to imatinib

scientific article published on 12 October 2015

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

scientific article published on 6 May 2011

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.

scientific article published on 29 February 2016

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

scientific article published on 31 March 2014

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

scientific article published on 8 October 2015

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

scientific article

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

scientific article published on 19 October 2018

Recent advances in understanding myelofibrosis and essential thrombocythemia

scientific article

Rethinking JAK2 inhibition: towards novel strategies of more specific and versatile janus kinase inhibition

scientific article published on 25 January 2017

Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex.

scientific article published on September 1994

Role of tyrosine kinases and phosphatases in polycythemia vera.

scientific article

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

scientific article published on 19 February 2009

Signal transduction molecule patterns indicating potential glioblastoma therapy approaches

scientific article

Small-molecule inhibitors in myeloproliferative neoplasms: are we aiming for the right targets?

scientific article published on January 1, 2012

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

scientific article

Stem cell generation and choice of fate: role of cytokines and cellular microenvironment

scientific article published in October 2000

Structural features of the KPI domain control APP dimerization, trafficking, and processing

scientific article published on 15 November 2011

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

scientific article

Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2.

scientific article

The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins

scientific article published on 20 August 2003

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction.

scientific article

The JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective

scientific article

The JAK2V617F mutation can occur in a hematopoietic stem cell that exhibits no proliferative advantage: a case of human allogeneic transplantation

scientific article published on 01 August 2008

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

scientific article published on 23 January 2008

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

scientific article (publication date: December 2001)

The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters

scientific article published on 11 January 2019

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

scientific article

The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid.

scientific article published in February 1998

The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation

scientific article

The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

scientific article published on 22 February 2007

The priming effect of human interferon-alpha is mediated by protein kinase C

scientific article published on 01 December 1990

The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling

scientific article published on 10 October 2007

Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms

scientific article

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.

scientific article published on 3 April 2018

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

scientific article published on 14 December 2015

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

scientific article published on 29 February 2012

Thrombopoietin receptor is required for the oncogenic function of CALR mutants.

scientific article published on 17 February 2016

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells ⬇️

scientific article published on September 30, 1997

Transmembrane signaling by IFN-alpha.

scientific article

Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation

scientific article published on 28 January 2013

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

scientific article published on 26 February 2015

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix

scientific article published on 30 March 2016

What is the role of amyloid precursor protein dimerization?

scientific article

Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms

scientific article published on 30 September 2015

miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets.

scientific article

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