List of works - Mario Losen

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis.

scientific article published on 24 December 2013

A novel method for making human monoclonal antibodies.

scientific article

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

scientific article published on 14 September 2007

Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction

scientific article published on August 2010

Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders

scientific article

Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients

scientific article published on 5 June 2013

B cell characterization and reactivity analysis in multiple sclerosis

scientific article published on 21 February 2009

Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient.

scientific article published on 31 October 2017

Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor

scientific article published on 16 January 2014

Complement activation by ceramide transporter proteins

scientific article published on 6 January 2014

DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content

scientific article published on 01 December 2004

Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures

scientific article

Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures

scientific article published in November 2003

Erratum: gene-environment interaction research and transgenic mouse models of Alzheimer's disease.

scientific article published on 10 January 2011

Familial occurrence of autoimmune myasthenia gravis with different antibody specificity

scientific article published on 01 May 2008

Gene-environment interaction research and transgenic mouse models of Alzheimer's disease

scientific article

Generation of polyclonal antibodies directed against G protein-coupled receptors using electroporation-aided DNA immunization

scientific article published in July 2008

Glycine receptor antibodies in PERM: a new channelopathy

scientific article

Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques

scientific article published on 6 March 2012

Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis.

scientific article published on 24 December 2014

Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs

scientific article published on 3 March 2015

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

scientific article

Immunoregulation in experimental autoimmune myasthenia gravis--about T cells, antibodies, and endplates

scientific article published in September 2003

Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil.

scientific article published on 29 July 2008

In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery

scientific article published on 16 October 2010

Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis

scientific article

Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

scientific article published on June 2008

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

scientific article published on 09 January 2019

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

scientific article

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.

scientific article published on 02 December 2013

MuSK myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient.

scientific article published on 13 March 2012

Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.

scientific article published in April 2014

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

scientific article published on 6 March 2012

Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity

scientific article published on 20 October 2011

Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety

scientific article published on 23 November 2020

Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis

scientific article published on February 2007

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle

scientific article (publication date: 14 January 2011)

Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.

scientific article published on 25 March 2013

Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis.

scientific article published on 14 January 2011

Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis patients

scientific article

Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

scientific article published on 18 June 2013

Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis.

scientific article published on 18 December 2010

Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

scientific journal article

Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors--Recommendations for methods and experimental designs

scientific article published on 18 March 2015

Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?

scientific article published on December 2012

The auto-antigen repertoire in myasthenia gravis.

scientific article published on August 2010

The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?

scientific article published on 17 March 2010

The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates

scientific article published on 10 September 2009

The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain

scientific article published on 23 June 2009

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

scientific journal article

Treatment of myasthenia gravis by preventing acetylcholine receptor modulation

scientific article

Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model

scientific article published in January 2012

List of works by Mario Losen

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis.

A novel method for making human monoclonal antibodies.

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction

Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders

Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients

B cell characterization and reactivity analysis in multiple sclerosis

Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient.

Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor

Complement activation by ceramide transporter proteins

DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content

Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures

Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures

Erratum: gene-environment interaction research and transgenic mouse models of Alzheimer's disease.

Familial occurrence of autoimmune myasthenia gravis with different antibody specificity

Gene-environment interaction research and transgenic mouse models of Alzheimer's disease

Generation of polyclonal antibodies directed against G protein-coupled receptors using electroporation-aided DNA immunization

Glycine receptor antibodies in PERM: a new channelopathy

Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques

Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis.

Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Immunoregulation in experimental autoimmune myasthenia gravis--about T cells, antibodies, and endplates

Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil.

In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery

Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis

Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.

MuSK myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient.

Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity

Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety

Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle

Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.

Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis.

Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis patients

Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.

Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis.

Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors--Recommendations for methods and experimental designs

Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?

The auto-antigen repertoire in myasthenia gravis.

The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?

The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates

The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

Treatment of myasthenia gravis by preventing acetylcholine receptor modulation

Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model