List of works - Christopher R. Vakoc

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response

scientific journal article

A new bump in the epigenetic landscape

scientific article

A rationale to target the SWI/SNF complex for cancer therapy

scientific article

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

scientific article published on December 2009

Acetylation of GATA-1 is required for chromatin occupancy

scientific article published on 3 August 2006

Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.

scientific article

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

scientific article

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

scientific article (publication date: 16 September 2011)

C/EBPα: critical at the origin of leukemic transformation

scientific article published on 06 January 2014

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

scientific article

Enhancer dysfunction in leukemia.

scientific article published on 9 February 2018

Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus

scientific article published on February 2008

FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.

scientific article

Global regulation of erythroid gene expression by transcription factor GATA-1

scientific article

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

scientific article published on 02 June 2009

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

scientific article published on 14 February 2013

Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin

scientific article

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation

scientific article published in December 2006

IκBζ is a dual-use coactivator of NF-κB and POU transcription factors

scientific article published in 2024

Low frequency of MLL3 mutations in colorectal carcinoma

scientific article published on March 2009

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

scientific article

Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes

scientific article

Oncogene interference through targeting of chromatin regulators

scientific article published on 22 April 2013

PAF is in the cabal of MLL1-interacting proteins that promote leukemia

scientific article published in June 2010

Profile of histone lysine methylation across transcribed mammalian chromatin

scientific article

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

scientific article published on February 2005

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

scientific article (publication date: 3 August 2011)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

scientific article

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

scientific journal article

Selective inhibition of tumor oncogenes by disruption of super-enhancers

scientific article (publication date: 11 April 2013)

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

scientific article published on 24 April 2020

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

scientific article

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

scientific article (publication date: 5 June 2014)

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

scientific article

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

scientific article published on 14 September 2015

WRAD: enabler of the SET1-family of H3K4 methyltransferases ⬇️

scientific article published on May 30, 2012

List of works by Christopher R. Vakoc

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response

A new bump in the epigenetic landscape

A rationale to target the SWI/SNF complex for cancer therapy

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

Acetylation of GATA-1 is required for chromatin occupancy

Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

C/EBPα: critical at the origin of leukemic transformation

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Enhancer dysfunction in leukemia.

Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus

FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.

Global regulation of erythroid gene expression by transcription factor GATA-1

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation

IκBζ is a dual-use coactivator of NF-κB and POU transcription factors

Low frequency of MLL3 mutations in colorectal carcinoma

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes

Oncogene interference through targeting of chromatin regulators

PAF is in the cabal of MLL1-interacting proteins that promote leukemia

Profile of histone lysine methylation across transcribed mammalian chromatin

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

Selective inhibition of tumor oncogenes by disruption of super-enhancers

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

WRAD: enabler of the SET1-family of H3K4 methyltransferases ⬇️