List of works by Alessandro Cannavo

Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology

scientific article published on 19 September 2018

Burning Redoxstats in the Brainstem: Lack of Nrf2 and the Rise of Hypertension.

scientific article published in May 2017

Changes of plasma norepinephrine and serum N-terminal pro-brain natriuretic peptide after exercise training predict survival in patients with heart failure

scientific article published on 22 December 2013

Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy.

scientific article published on 6 December 2014

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

scientific article

EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.

scientific article published on 3 March 2011

Eating Away at Heart Failure

scientific article published on 01 December 2015

GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells

scientific article published on 01 March 2017

GRK2 as a therapeutic target for heart failure

scientific article published on 23 November 2017

GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease

scientific article published on 7 January 2017

GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility.

scientific article published on 28 August 2013

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels

scientific article

Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure.

scientific article published on 20 May 2013

Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor

scientific article

Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure

scientific article published on 10 June 2016

Impact of diabetes mellitus on lymphocyte GRK2 protein levels in patients with heart failure.

scientific article published on February 2015

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

scientific article

Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload.

scientific article

Molecular aspects of the cardioprotective effect of exercise in the elderly

scientific article published on 15 August 2013

Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

scientific article published on 2 March 2016

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms

scientific article

Novel missense mutations and unexpected multiple changes of RYR1 gene in 75 malignant hyperthermia families

article

Predisposing factors to heart failure in diabetic nephropathy: a look at the sympathetic nervous system hyperactivity

scientific article published on 01 June 2018

Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure

scientific article published on 16 February 2016

Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation

scientific article published in October 2013

Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure

scientific article published on 20 May 2013

Risk of acute myocardial infarction after transurethral resection of prostate in elderly

scientific article

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

scientific article published on 23 August 2017

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

scientific article

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

scientific article

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

scientific article

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy

scientific article published on 26 September 2013

Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.

scientific article

Vascular endothelial growth factor blockade prevents the beneficial effects of β-blocker therapy on cardiac function, angiogenesis, and remodeling in heart failure

scientific article published on 12 September 2013

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

scientific article published on 12 June 2017

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

scientific article

β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy?

scientific article published on January 2013

β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling.

scientific article published in July 2017

β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy

scientific article

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