List of works - Ana Pombo

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

scientific article

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

article

Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations

scientific article published on 25 April 2006

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

scientific article

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

scientific article

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

scientific article published on 16 May 2010

Three-dimensional genome architecture: players and mechanisms

scientific article

Formation of new chromatin domains determines pathogenicity of genomic duplications

scientific article

Active RNA polymerases are localized within discrete transcription "factories' in human nuclei

scientific article published on 01 June 1996

Complexity of chromatin folding is captured by the strings and binders switch model

scientific article

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

scientific article published on February 2012

Complex multi-enhancer contacts captured by genome architecture mapping.

scientific article published on 8 March 2017

Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response

scientific article

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.

scientific article published on 23 December 2015

Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

scientific article

Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.

scientific article published on April 1999

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

scientific article

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

scientific article published on 11 July 2016

Modifications of RNA polymerase II are pivotal in regulating gene expression states

scientific article published on 16 October 2009

Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells

scientific article

Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain

scientific article

Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle

scientific article

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

scientific article

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

scientific article published on 28 October 2009

Chromosome organization: new facts, new models

scientific article published on 2 January 2007

Poised transcription factories prime silent uPA gene prior to activation

scientific article

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

scientific article

Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells

scientific article published in May 2004

Gene positioning

scientific article

Correlative fluorescence and electron microscopy on ultrathin cryosections: bridging the resolution gap.

scientific article

Models of chromosome structure

scientific article published on May 4, 2014

The topology of transcription by immobilized polymerases.

scientific article published on December 1996

Bridging the Resolution Gap: Imaging the Same Transcription Factories in Cryosections by Light and Electron Microscopy

article

Functional organisation of the genome during interphase

scientific article published on 24 October 2007

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.

scientific article published on 9 May 2017

Genome function and nuclear architecture: from gene expression to nanoscience

scientific article

Transcription factories: quantitative studies of nanostructures in the mammalian nucleus

scientific article

Polymer physics predicts the effects of structural variants on chromatin architecture

scientific article published on 16 April 2018

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Eukaryotic gene regulation in three dimensions and its impact on genome evolution

scientific article

The localization of sites containing nascent RNA and splicing factors.

scientific article published on December 1996

Changes in chromosome organization during PHA-activation of resting human lymphocytes measured by cryo-FISH

scientific article published on 01 January 2008

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

scientific article

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

scientific article published on 19 December 2015

Measuring the size of biological nanostructures with spatially modulated illumination microscopy

scientific article published on 12 March 2004

An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

scientific article

Specialized transcription factories within mammalian nuclei.

scientific article

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.

scientific article published on 24 April 2017

Distribution of different phosphorylated forms of RNA polymerase II in relation to Cajal and PML bodies in human cells: an ultrastructural study

scientific article published on 27 September 2005

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

scientific article

List of works by Ana Pombo

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Three-dimensional genome architecture: players and mechanisms

Formation of new chromatin domains determines pathogenicity of genomic duplications

Active RNA polymerases are localized within discrete transcription "factories' in human nuclei

Complexity of chromatin folding is captured by the strings and binders switch model

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

Complex multi-enhancer contacts captured by genome architecture mapping.

Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.

Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

Modifications of RNA polymerase II are pivotal in regulating gene expression states

Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells

Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain

Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

Chromosome organization: new facts, new models

Poised transcription factories prime silent uPA gene prior to activation

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells

Gene positioning

Correlative fluorescence and electron microscopy on ultrathin cryosections: bridging the resolution gap.

Models of chromosome structure

The topology of transcription by immobilized polymerases.

Bridging the Resolution Gap: Imaging the Same Transcription Factories in Cryosections by Light and Electron Microscopy

Functional organisation of the genome during interphase

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.

Genome function and nuclear architecture: from gene expression to nanoscience

Transcription factories: quantitative studies of nanostructures in the mammalian nucleus

Polymer physics predicts the effects of structural variants on chromatin architecture

FANTOM5 CAGE profiles of human and mouse samples

Eukaryotic gene regulation in three dimensions and its impact on genome evolution

The localization of sites containing nascent RNA and splicing factors.

Changes in chromosome organization during PHA-activation of resting human lymphocytes measured by cryo-FISH

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

Measuring the size of biological nanostructures with spatially modulated illumination microscopy

An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

Specialized transcription factories within mammalian nuclei.

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.

Distribution of different phosphorylated forms of RNA polymerase II in relation to Cajal and PML bodies in human cells: an ultrastructural study

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression