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List of works by Ana Pombo

3D chromatin regulation of Sonic hedgehog in the limb buds

scientific article published in January 2009

A Finer Print Than TADs: PRC1-Mediated Domains.

scientific article published in February 2017

A model of the large-scale organization of chromatin

scientific article published on April 2013

A polymer model explains the complexity of large-scale chromatin folding

scientific article published on 19 June 2013

Active RNA polymerases are localized within discrete transcription "factories' in human nuclei

scientific article published on 01 June 1996

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.

scientific article published on 24 April 2017

Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells

scientific article

Advances in imaging the interphase nucleus using thin cryosections

scientific article published on 17 July 2007

An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

scientific article

Bridging the Resolution Gap: Imaging the Same Transcription Factories in Cryosections by Light and Electron Microscopy

article

CD8 alpha is an activation marker for a subset of peripheral CD4 T cells

scientific article

Cell cycle: Continuous chromatin changes

scientific article published in July 2017

Cell-type specialization is encoded by specific chromatin topologies

scientific article published on 17 November 2021

Cellular genomics: which genes are transcribed, when and where?

scientific article

Challenges and guidelines toward 4D nucleome data and model standards

scientific article published on 27 September 2018

Changes in chromosome organization during PHA-activation of resting human lymphocytes measured by cryo-FISH

scientific article published on 01 January 2008

Chromosome organization: new facts, new models

scientific article published on 2 January 2007

Code breaking: The RNAPII modification code in pluripotency ⬇️

scientific article published on 01 April 2012

Complex multi-enhancer contacts captured by genome architecture mapping.

scientific article published on 8 March 2017

Complexity of chromatin folding is captured by the strings and binders switch model

scientific article

Correction: Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region.

scientific article published on 28 March 2008

Correlative fluorescence and electron microscopy on ultrathin cryosections: bridging the resolution gap.

scientific article

CryoFISH: fluorescence in situ hybridization on ultrathin cryosections

scientific article

Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response

scientific article

Desmin immunolocalisation in autosomal dominant Emery-Dreifuss muscular dystrophy

scientific article published on 27 February 2007

Distribution of different phosphorylated forms of RNA polymerase II in relation to Cajal and PML bodies in human cells: an ultrastructural study

scientific article published on 27 September 2005

Erratum: Three-dimensional genome architecture: players and mechanisms

scholarly article published in Nature Reviews Molecular Cell Biology

Eukaryotic gene regulation in three dimensions and its impact on genome evolution

scientific article

Examining Topological Domain Influence on Enhancer Function

scientific article published in December 2016

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells

scientific article published in May 2004

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

scientific article

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

article

Formation of new chromatin domains determines pathogenicity of genomic duplications

scientific article

From linear genome sequence to three-dimensional organization of the cell nucleus

scientific article

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

scientific article

Functional organisation of the genome during interphase

scientific article published on 24 October 2007

Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription

scientific article published on 25 July 2016

Gene positioning

scientific article

Genome function and nuclear architecture: from gene expression to nanoscience

scientific article

Genomics meets nanoscience: probing genes and the cell nucleus at 10-9 meters

scientific article

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.

scientific article published on 23 December 2015

Interaction of proteins with promoter elements of the human U2 snRNA genes in vivo

scientific article published in October 2003

Interactions of adenovirus with the nucleus of the host cell

scholarly article by Ana Pombo published in December 1995

Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations

scientific article published on 25 April 2006

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

scientific article published on 16 May 2010

Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes

scientific article published in May 2017

LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 07 September 2020

Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

scientific article

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.

scientific article published on 9 May 2017

Mean Expression of the X-Chromosome is Associated with Neuronal Density

scientific article

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

scientific article published on 28 October 2009

Measuring the size of biological nanostructures with spatially modulated illumination microscopy

scientific article published on 12 March 2004

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

scientific article published on 11 July 2016

Mechanisms regulating S phase progression in mammalian cells

scientific article published on January 2009

Methods for mapping 3D chromosome architecture

scientific article published on 17 December 2019

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

scientific article published on 19 December 2015

Models of chromosome structure

scientific article

Modifications of RNA polymerase II are pivotal in regulating gene expression states

scientific article published on 16 October 2009

Nuclear Architecture in Stem Cells

scientific article published on 01 January 2010

Nuclear cell biology ⬇️

scientific article published on March 15, 2011

Nucleus and gene expression: the structure and function conundrum

article

On the structure of replication and transcription factories

scientific article published on January 1995

Phenotypic analysis of peripheral CD4+ CD8+ T cells in the rat

article

Physical mechanisms behind the large scale features of chromatin organization

scientific article

Poised transcription factories prime silent uPA gene prior to activation.

scientific article

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

scientific article published on February 2012

Polycomb targets seek closest neighbours

scientific article

Polymer models of chromatin organization

scientific article published on 20 June 2013

Polymer models of the organization of chromosomes in the nucleus of cells

Polymer physics predicts the effects of structural variants on chromatin architecture

scientific article published on 16 April 2018

Polymer physics, scaling and heterogeneity in the spatial organisation of chromosomes in the cell nucleus

Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease

scientific article

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 17 March 2021

R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes

article

RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation.

scientific article published on 16 October 2017

Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle

scientific article

Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.

scientific article published on April 1999

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

scientific article

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

article

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

scientific article

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

scientific article

Specialized transcription factories within mammalian nuclei.

scientific article

Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain

scientific article

Stem Cell Epigenetics: Looking Forward

scientific article published on 01 June 2014

The localization of sites containing nascent RNA and splicing factors.

scientific article published on December 1996

The molecular basis for stability of heterochromatin-mediated silencing in mammals

scientific article

The topology of transcription by immobilized polymerases.

scientific article published on December 1996

Three-dimensional genome architecture: players and mechanisms

scientific article

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

scientific article

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

scientific article

Transcription factories: quantitative studies of nanostructures in the mammalian nucleus

scientific article

Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

scientific article

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