List of works - Opher Gileadi

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

scientific article published on 13 June 2019

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

scientific article published on 8 November 2010

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

scientific article

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

scientific article

Analysis of the Ac promoter: structure and regulation

scientific article published in May 1998

Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

scientific article

Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression

scientific article

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

scientific article published on 11 November 2019

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

scientific article

CTD kinase associated with yeast RNA polymerase II initiation factor b.

scientific article

Cak1 Is Required for Kin28 Phosphorylation and Activation In Vivo.

scientific article published in March 2000

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

scientific article published on 28 April 2016

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

scientific article

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

scientific article published on 26 January 2008

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Crystal structures of the catalytic domain of human soluble guanylate cyclase

scientific article

Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions.

scholarly article

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities

scientific article

EXD2 promotes homologous recombination by facilitating DNA end resection

scientific journal article

Electron microscopy of wet tissues: a case study in renal pathology

scientific article

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

scientific article published on 19 October 2011

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

scientific article published on 03 December 2021

Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast

scientific article published on 01 April 2000

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins

scientific article published on 17 November 2010

High-throughput production of human proteins for crystallization: the SGC experience.

scientific article

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I

scientific article published on 28 May 2013

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

scientific article

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

scientific article published on September 2011

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

scientific journal article

Identification of human satellite DNA sequences associated with chemically resistant nonhistone polypeptide adducts

scientific article published on October 1, 1992

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

scientific article published on 15 October 2019

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

scientific article published on 18 January 2017

Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo

scientific article published in April 2001

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

scientific article

Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta

scientific article published on 01 January 1984

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

scientific article

Medium-throughput production of recombinant human proteins: ligation-independent cloning

scientific article published on 01 January 2014

Medium-throughput production of recombinant human proteins: protein production in E. coli

scientific article published on 01 January 2014

Medium-throughput production of recombinant human proteins: protein production in insect cells

scientific article published on January 2014

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

scientific article published on 27 October 2016

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization

scientific article

Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression

scientific article

Protein production and purification

scientific article

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

scientific article published on February 2014

Scanning electron microscopy of cells and tissues under fully hydrated conditions

scholarly article

Squid sperm to clam eggs: imaging wet samples in a scanning electron microscope.

scientific article

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

scientific article published in Scientific Reports

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

scientific article

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

scientific article

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases

scientific article published on 6 December 2011

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

scientific article published on 27 September 2013

Structural basis of fumarate hydratase deficiency

scientific article

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

scientific article published on 10 February 2015

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

scientific article published on December 2015

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

scientific article published on 16 November 2020

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

scientific article

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

scientific article

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

scientific article published on February 2014

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.

scientific article

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

scientific article published on 13 August 2013

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

scientific article published on 7 May 2012

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

scientific article published on 30 December 2019

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

scientific article published on September 2007

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

scientific article published on 17 November 2015

Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta

scientific article published on July 1, 1992

List of works by Opher Gileadi

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

Analysis of the Ac promoter: structure and regulation

Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

CTD kinase associated with yeast RNA polymerase II initiation factor b.

Cak1 Is Required for Kin28 Phosphorylation and Activation In Vivo.

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Crystal structures of the catalytic domain of human soluble guanylate cyclase

Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions.

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities

EXD2 promotes homologous recombination by facilitating DNA end resection

Electron microscopy of wet tissues: a case study in renal pathology

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins

High-throughput production of human proteins for crystallization: the SGC experience.

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

Identification of human satellite DNA sequences associated with chemically resistant nonhistone polypeptide adducts

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

Medium-throughput production of recombinant human proteins: ligation-independent cloning

Medium-throughput production of recombinant human proteins: protein production in E. coli

Medium-throughput production of recombinant human proteins: protein production in insect cells

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization

Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression

Protein production and purification

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

Scanning electron microscopy of cells and tissues under fully hydrated conditions

Squid sperm to clam eggs: imaging wet samples in a scanning electron microscope.

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Structural basis of fumarate hydratase deficiency

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta