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List of works by William M. Wuest

A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

scientific article published on 12 November 2019

A concise synthesis of carolacton

scientific article published on 31 January 2014

A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

scientific article published on June 2017

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

scientific article published on 29 July 2019

An Investigation Into Rigidity-Activity Relationships in bisQAC Amphiphilic Antiseptics

scientific article published on 18 December 2018

Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study

scientific article published on 20 December 2019

Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?

scientific article published on 15 May 2020

Beyond paraquats: dialkyl 3,3'- and 3,4'-bipyridinium amphiphiles as antibacterial agents

scientific article published on 14 July 2014

Biofilm-eradicating properties of quaternary ammonium amphiphiles: simple mimics of antimicrobial peptides.

scientific article

Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product

scientific article published on 10 September 2018

Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus

scientific article

Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles.

scientific article published in June 2016

Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development

scientific article published on 18 November 2020

Computational screening and selection of cyclic peptide hairpin mimetics by molecular simulation and kinetic network models.

scientific article published on 2 May 2014

Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance

scientific article published on 21 March 2019

Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

scientific article

Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity

scientific article

Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action

article

Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis

scientific article

Epoxy isonitriles, a unique class of antibiotics - Synthesis of their metabolites and biological investigations

article

EroS Enzyme from Aliivibrio fischeri Plays Cupid to Choanoflagellates

scientific article

Ester- and amide-containing multiQACs: Exploring multicationic soft antimicrobial agents

scientific article

From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?

article

Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical "Hot-Wiring": An Under-explored Avenue for Therapeutic Development

scientific article published on 19 April 2019

Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.

scientific article published on 13 December 2017

Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)

article

Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts

scientific article published on 29 July 2008

Molecular Simulation of Conformational Pre-Organization in Cyclic RGD Peptides

scientific article

Natural Products as Platforms To Overcome Antibiotic Resistance

scientific article published on 27 September 2017

Natural product-derived quaternary ammonium compounds with potent antimicrobial activity

scientific article published on 18 November 2015

Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials

scientific article published on 29 August 2016

Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.

scientific article published on 4 January 2018

Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance

scientific article published on 29 May 2015

Scaffold-Hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials

scientific article published on 11 September 2015

Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics

scientific article published on 10 April 2019

Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes

scientific article

SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A.

scientific article published on December 2009

Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans

scientific article published on 25 June 2019

TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents

scientific article published on 4 December 2013

Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase

scientific article published on 14 April 2020

Targeting S. mutans biofilms: a perspective on preventing dental caries

scientific article published on 19 March 2019

The Development of Next-Generation Pyridinium-Based multiQAC Antiseptics

scientific article

The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms

scientific article published on 23 October 2014

The enantioselective synthesis and biological evaluation of chimeric promysalin analogs facilitated by diverted total synthesis

scientific article published on 10 February 2016

The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes

scientific article published on 07 July 2020

Three siderophores from one bacterial enzymatic assembly line

scientific article published on April 2009

Total synthesis and biological investigation of (-)-promysalin

scientific article published on 05 June 2015

Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy

scientific article published on 18 April 2020

Total synthesis of (-)-2-epi-peloruside A.

scientific article published on December 2008

Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440

scientific article published on 05 June 2018

Tricepyridinium-inspired QACs yield potent antimicrobials and provide insight into QAC resistance

scientific article published on 07 October 2020

Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.

scientific article

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