List of works by Mathieu Vinken

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

3Rs toxicity testing and disease modeling projects in the European Horizon 2020 research and innovation program

scientific article published on 09 June 2020

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity

scientific article published on 04 April 2019

A putative AOP for pneumonia related to COVID-19

scientific article published on 20 July 2020

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

scientific article published on 02 July 2015

Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity.

scientific article

Adverse outcome pathway development from protein alkylation to liver fibrosis

scientific article

Adverse outcome pathways: a concise introduction for toxicologists

scientific article published on 28 June 2017

Adverse outcome pathways: hype or hope?

scientific article published on 19 July 2013

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.

scientific article

An Update on Adverse Outcome Pathways Leading to Liver Injury.

scientific article published on 6 December 2017

Analysis of Liver Connexin Expression Using Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction

scientific article published on January 2016

Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife

scientific article published on November 2014

Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment

scientific article published on 20 November 2020

Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death

scientific article

Biology and pathobiology of gap junctional channels in hepatocytes

scientific article published on March 2008

Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action

scientific article published on 28 January 2014

Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis

scientific article published on 05 December 2019

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop

scientific article published in January 2022

Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells

scientific article published on 4 August 2009

Calcium and connexin-based intercellular communication, a deadly catch?

scientific article published on 31 May 2011

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

scientific article published on 10 February 2017

Cell junctions and oral health

scientific article published on 07 June 2019

Characterization of hepatocyte-based in vitro systems for reliable toxicity testing

scientific article published on 23 August 2018

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes.

scientific article

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

scientific article published on 29 June 2019

Cholestasis Differentially Affects Liver Connexins

scientific article published on 07 September 2020

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

scientific article published on 26 December 2019

Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow

scientific article

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

scientific article published on 14 July 2018

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

scientific article

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

scientific article published on 8 April 2012

Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice.

scientific article published on 9 April 2015

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

scientific article published on 26 September 2008

Connexin and pannexin (hemi)channels in the liver.

scientific article published on 10 January 2014

Connexin and pannexin (hemi)channels: emerging targets in the treatment of liver disease

article

Connexin and pannexin signaling in gastrointestinal and liver disease

scientific article

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

scientific article

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice

scientific article published on 4 July 2017

Connexin hemichannels: novel mediators of toxicity

scientific article

Connexin-based signaling and drug-induced hepatotoxicity

scientific article published on 12 February 2017

Connexin-related signaling in cell death: to live or let die?

scientific article published on 06 February 2009

Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice

scientific article

Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis

scientific article published on 17 November 2016

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

scientific article published on 4 December 2009

Connexin32: a mediator of acetaminophen-induced liver injury?

scientific article published on 07 January 2016

Connexin43 signaling contributes to spontaneous apoptosis in cultures of primary hepatocytes

scientific article published on 14 October 2011

Connexins and pannexins in liver damage

scientific article

Connexins and their channels in cell growth and cell death

scientific article

Connexins and their channels in inflammation

scientific article

Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases

scientific article

Connexins: sensors and regulators of cell cycling.

scientific article published on 27 August 2010

Critical selection of reliable reference genes for gene expression study in the HepaRG cell line

scientific article published on 15 March 2011

Current insights in the complexities underlying drug-induced cholestasis

scientific article published on 01 July 2019

DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes

scientific journal article

Detection of Connexins in Liver Cells Using Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis and Immunoblot Analysis.

scientific article published on January 2016

Development and characterization of a new human hepatic cell line.

scientific article

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

scientific article published on 14 August 2013

Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?

scientific article

Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

scientific article published on 15 February 2008

Differential role of epigenetic modulators in malignant and normal stem cells: a novel tool in preclinical in vitro toxicology and clinical therapy

scientific article published on 27 March 2007

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

scientific article published on 22 May 2019

Drug-induced liver injury: mechanisms, types and biomarkers

scientific article published in January 2013

ESTIV2018: 20th anniversary of the International Congress on In Vitro Toxicology

scientific article published on 18 June 2019

Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes.

scientific article

Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes

scientific article published in January 2010

Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels

scientific article published in 2022

Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels

scientific article published in 2022

Effects of Trichostatin A on drug uptake transporters in primary rat hepatocyte cultures

scientific article published on 5 May 2015

Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology

scientific article published on October 2010

Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?

scientific article published on 29 August 2008

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

scientific article published on 27 February 2017

Establishment of Sandwich Cultures of Primary Human Hepatocytes

scientific article published on 01 January 2019

Experimental models of hepatotoxicity related to acute liver failure

scientific article

Experimental models of liver fibrosis

scientific article

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 22 September 2017

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

scientific article published on July 2009

Gap junctions and non-neoplastic liver disease.

scientific article published on 16 May 2012

Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model

scholarly article by Sara Crespo Yanguas et al published August 2018 in Archives of Toxicology

Hepatocytes in suspension

scientific article published on 01 January 2006

Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models

scientific article published on 06 November 2020

Histone deacetylase inhibitors as potent modulators of cellular contacts.

scientific article published on June 2006

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals

scientific article published on 21 September 2013

IP3, a small molecule with a powerful message

scientific article published on 02 January 2013

Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes

scientific article published on January 2015

Immunohisto- and Cytochemistry Analysis of Connexins.

scientific article published on January 2016

In Vitro Veritas

scientific article published on 12 March 2020

In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist

scientific article published on 24 March 2018

In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death.

scientific article published on 6 December 2016

Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation

scientific article published on 22 October 2019

Industrial, Biocide, and Cosmetic Chemical Inducers of Cholestasis

scientific article published on 18 June 2019

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory

scientific article published on 20 December 2016

Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.

scientific article

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents.

scientific article published on 23 April 2018

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

scientific article published on 15 August 2017

Inhibition of gap junctional intercellular communication by toxic metals.

scientific article published on 24 September 2010

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

scientific article

Inhibitors of connexin and pannexin channels as potential therapeutics

scientific article

Introduction: connexins, pannexins and their channels as gatekeepers of organ physiology.

scientific article

Involvement of cell junctions in hepatocyte culture functionality

scientific article published on April 2006

Involvement of connexin43 in acetaminophen-induced liver injury.

scientific article

Isolation of rat hepatocytes.

scientific article

Junctional structures and hepatocellular carcinoma: from the lab to the clinic?

scientific article

Key performance indicators of the contemporary European academic toxicologist

scientific article published on 02 May 2019

Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes

scientific article published in December 2002

Making sense of in vitro methods. Proceedings of the 18th ESTIV congress

scientific article published on 01 September 2015

Measurement of Apoptotic and Necrotic Cell Death in Primary Hepatocyte Cultures

scientific article published in January 2015

Mechanisms and in vitro models of drug-induced cholestasis

scientific article published on 10 April 2019

Mechanisms of Drug-Induced Cholestasis

scientific article published on 01 January 2019

MicroRNAs as key regulators of xenobiotic biotransformation and drug response.

scientific article

Models and methods for in vitro testing of hepatic gap junctional communication

scientific article

Modifications in connexin expression in liver development and cancer

scientific article published on August 2012

Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes

scientific journal article

Modulation of connexin signaling by bacterial pathogens and their toxins

scientific article published on 09 June 2011

Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures.

scientific article published on August 2006

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

scientific article published on 08 June 2020

New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop

scientific article published on 23 April 2020

Non-canonical roles of connexins

scientific article published on 24 March 2020

Non-channel functions of connexins in cell growth and cell death

scientific article published on 22 June 2011

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

article

Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

scientific article published on 05 December 2011

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.

scientific article published on 03 August 2010

Pannexin1 as mediator of inflammation and cell death.

scientific article

Paracrine signaling through plasma membrane hemichannels

scientific article published on 13 July 2012

Peptide-based targeting of connexins and pannexins for therapeutic purposes

scientific article published on 15 June 2020

Preliminary in vivo evaluation of [131I]-2-iodo-D-phenylalanine as a potential radionuclide therapeutic agent in R1M-fluc rhabdomyosarcoma tumor-bearing NuNu mice using bioluminescent imaging.

scientific article published in April 2010

Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor

scientific article published on 12 October 2010

Primary hepatocyte cultures as in vitro tools for toxicity testing: quo vadis?

scientific article published on 12 January 2012

Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.

scientific article published on February 2013

Primary hepatocytes and their cultures for the testing of drug-induced liver injury

scientific article published on 01 September 2018

Primary hepatocytes and their cultures in liver apoptosis research

scientific article

Proceedings of the 17th ESTIV congress 2012

scientific article published on 31 October 2013

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).

scientific article

Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes

scientific article

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

scientific article

Proteomic analysis of global protein expression changes in the endothelin-1 rat model for cerebral ischemia: rescue effect of mild hypothermia.

scientific article published on 6 August 2013

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures

scientific article published on 7 December 2012

Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies

Purinergic signalling during sterile liver injury

scientific article

Rat Hepatocyte Cultures : Collagen Gel Sandwich and Immobilization Cultures

scientific article published in January 2006

Rat Hepatocyte Cultures : Conventional Monolayer and Cocultures With Rat Liver Epithelial Cells

scientific article published in January 2006

Rat hepatocyte cultures: collagen gel sandwich and immobilization cultures

scientific article published on 01 January 2006

Rat hepatocyte cultures: conventional monolayer and cocultures with rat liver epithelial cells

scientific article published on 01 January 2006

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

scientific article (publication date: 19 April 2016)

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Regulation of connexin signaling by the epigenetic machinery

scientific article

Regulation of connexin- and pannexin-based channels by post-translational modifications.

scientific article published on 17 July 2013

Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury

scientific article published on 10 March 2020

Role of connexin-related signalling in hepatic homeostasis and its relevance for liver-based in vitro modelling

scientific article

Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation.

scientific article published on 02 April 2009

Roles of connexins and pannexins in digestive homeostasis

scientific article

Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019

scientific article published on 24 August 2020

Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients

scientific article

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

scientific article published on 8 November 2012

Strategies for immortalization of primary hepatocytes

scientific article

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

scientific article

Structure, Regulation and Function of Gap Junctions in Liver.

scientific article published on 22 March 2016

Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes

scientific article published on 29 March 2011

TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice.

scientific article

Taking adverse outcome pathways to the next level

scientific article published on 06 April 2018

Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

scientific article published on 22 June 2020

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?

scientific article published on 28 May 2014

The HepaRG cell line: a valuable in vitro tool for hepatitis virus infection studies

scientific article published on 14 February 2013

The adverse outcome pathway concept: a pragmatic tool in toxicology.

scientific article published on 23 August 2013

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

scientific article published on 26 April 2008

The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.

scientific article published on 21 April 2014

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation

scientific article published on 23 September 2013

The novel histone deacetylase inhibitor 4-Me2N-BAVAH differentially affects cell junctions between primary hepatocytes

scientific article published on 07 April 2007

The role and therapeutic potential of connexins, pannexins and their channels in Parkinson's disease

scientific article published on 12 March 2019

The use of adverse outcome pathways in the safety evaluation of food additives

scientific article published on 17 February 2020

The use of social media in scientific research and creative thinking

scientific article published on 05 April 2019

Towards an integrated in vitro strategy for repeated dose toxicity testing

scientific article published on 22 April 2011

Toxicogenomics directory of chemically exposed human hepatocytes

scientific article

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

scientific article published on 7 February 2013

Transfer of IP₃ through gap junctions is critical, but not sufficient, for the spread of apoptosis

scientific article published on 25 November 2011

Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes

scientific article published on 25 October 2006

Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes

scientific article published on 10 March 2006

Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?

scientific article published on 2 October 2013

What is understood by "animal-free research"?

scientific article published on 05 March 2019

[The role of intercellular communication via "gap junctions" in disease]

scientific article published on 01 December 2003

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