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List of works by Prahlad T. Ram

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

scientific article

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

scientific article published on 4 April 2016

A pan-cancer proteomic perspective on The Cancer Genome Atlas.

scientific article

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

scientific article

Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer

scientific article published on 18 November 2015

An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells

scientific article published on 17 February 2007

Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells

scientific article published on 19 October 2010

Bioinformatics and systems biology

scientific article

Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer

scientific article

Cancer Systems Biology: a peek into the future of patient care?

scientific article published on 04 February 2014

Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47)

scientific article

Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells

scientific article published in October 2002

Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

scientific article

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

scientific article

Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas

scientific article published on 28 January 2015

Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.

scientific article

Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin

scientific article

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

scientific article published on 04 May 2016

Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors

scientific article published on 01 June 1998

Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis

scientific article

Expression patterns of novel genes during mouse preimplantation embryogenesis.

scientific article published on February 1994

FABP4 as a key determinant of metastatic potential of ovarian cancer

scientific article published in Nature Communications

Formation of regulatory patterns during signal propagation in a Mammalian cellular network

scientific article

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer

scientific article published on 01 February 2016

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.

scientific article published on 2 February 2015

G protein pathways

scientific article

Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers

scientific article

Hypothesis generation in signaling networks

scientific article published in November 2006

Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis

scientific article

Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer

scientific article

Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma

scientific article published on 8 October 2014

Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer

scientific article

Involvement of the mt1 melatonin receptor in human breast cancer

scientific article published in May 2002

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

scientific article published on 13 June 2011

MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

scientific article

Mapping network motif tunability and robustness in the design of synthetic signaling circuits

scientific article

Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells

scientific article published in January 2002

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

scientific journal article

NetWalker: a contextual network analysis tool for functional genomics

scientific article

Network Motifs in JNK Signaling.

scientific article published on September 2013

Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.

scientific article published on 2 January 2008

Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma

scientific article published on 11 June 2016

Notch3 pathway alterations in ovarian cancer.

scientific article

Overexpression of Tightly Regulated Proteins: Protein Phosphatase 2A Overexpression in NIH 3T3 Cells ⬇️

scientific article published on January 1, 2002

Patterns of human gene expression variance show strong associations with signaling network hierarchy ⬇️

scientific article published on November 12, 2010

Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma

scientific article published on 29 October 2013

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4

scientific article published on 12 November 2018

Quantitative information management for the biochemical computation of cellular networks

scientific article published on 24 August 2004

Rapidly exploring structural and dynamic properties of signaling networks using PathwayOracle

scientific article

Reporter gene expression in G2 of the 1-cell mouse embryo

scientific article published on 01 April 1993

Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers

scientific article published on 27 October 2015

Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death

scientific article

Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein.

scientific article

Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p

scientific article published on 26 September 2016

Targeting SRC in mucinous ovarian carcinoma.

scientific article

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

scientific article published on November 2016

The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3.

scientific article

The ZNF304-integrin axis protects against anoikis in cancer

scientific journal article

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

scientific article

The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks

scientific article

Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin

scientific article

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

scientific article (publication date: 27 February 2016)

Tumour angiogenesis regulation by the miR-200 family

scientific article published on January 2013

Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data

scientific article

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