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List of works by Ugo Testa

"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor

scientific article published on 01 September 1990

A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes.

scientific article published in August 2015

A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes

scientific article published on 14 September 2009

A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells

scientific article

A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

scientific article published on 9 February 2007

Analysis of p73 expression pattern in acute myeloid leukemias: lack of DeltaN-p73 expression is a frequent feature of acute promyelocytic leukemia

scientific article published on 01 November 2004

Anti-tumor effects of interleukin-2 and interleukin-1 in mice transplanted with different syngeneic tumors.

scientific article

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

scientific article published on January 1998

Astrocyte cultures from human embryonic brain: characterization and modulation of surface molecules by inflammatory cytokines

scientific article published on August 1992

Autocrine role of angiopoietins during megakaryocytic differentiation

scientific article

Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.

scientific article published on 24 October 2002

Autologous stem cell transplantation: evaluation of erythropoietic reconstitution by highly fluorescent reticulocyte counts, erythropoietin, soluble transferrin receptors, ferritin, TIBC and iron dosages

scientific article published on 01 March 1997

Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles

scientific article published on 01 September 1994

Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

scientific article published on 4 November 2009

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments

scientific article published on 23 March 2020

C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia.

scientific article

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

scientific article published on 10 February 2014

CDDO-Im is a stimulator of megakaryocytic differentiation.

scientific article published on 29 October 2010

Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors ⬇️

scientific article published on July 15, 1992

Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors

scientific article (publication date: July 2009)

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications

scientific article published on 30 July 2019

Change in i-antigen expression of erythrocytes during in vivo aging

scientific article published on 01 June 1981

Circulating CD34+ Cells Are Decreased in Chronic Obstructive Pulmonary Disease

scientific article published on 01 August 2006

Circulating haemopoietic and endothelial progenitor cells are decreased in COPD

scientific article published on 01 March 2006

Circulating hematopoietic progenitor cells in runners

scientific article published in November 2002

Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay.

scientific article published on May 1982

Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.

scientific article

Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.

scientific article

Combined interleukin 1/interleukin 2 therapy of mice injected with highly metastatic Friend leukemia cells: host antitumor mechanisms and marked effects on established metastases ⬇️

scientific article published on February 1, 1991

Comparative patterns of i-antigen expression, F-cell frequency and Hb A2 level in acute myeloid leukemia and in acute lymphoid leukemia

scientific article published on 01 January 1981

Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.

scientific article published in August 2003

Correlations between progression of coronary artery disease and circulating endothelial progenitor cells.

scientific article published on 7 January 2010

Cytokine regulation of astrocyte function: in-vitro studies using cells from the human brain

scientific article published on 01 June 1995

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines

scientific article published on 12 August 2015

Defect in glycosylation of erythrocyte membrane proteins in congenital dyserythropoietic anaemia type II (HEMPAS).

scientific article

Differentiation of U-937 human monocyte-like cell line by 1α,25-dihydroxyvitamin D3 or by retinoic acid

scientific article published on 01 April 1985

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

scientific article published on 31 May 2005

Disappearance of Hb F and i antigen during the first year of life

scientific article published on 01 January 1980

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.

scientific article

Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation

scientific article

Effective erythropoiesis and HbF reactivation induced by kit ligand in beta-thalassemia.

scientific article

Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis

scientific article published in October 2002

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism

scientific article published on 22 February 2019

Endothelial progenitors

scientific article

Enforced expression of KDR receptor promotes proliferation, survival and megakaryocytic differentiation of TF1 progenitor cell line.

scientific article published on January 2006

Erythroid properties of K562 cells. Effect of hemin, butyrate and TPA induction

scientific article published on 01 July 1983

Experimental and investigational therapies for chemotherapy-induced anemia.

scientific article published on 10 September 2015

Expression and in-vitro modulation of HLA antigens in ontogenic development of human hemopoietic system

scientific article published on 01 January 1987

Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis

scientific article published on 01 June 1999

Expression of SSEA-I antigen (3-fucosyl-N-acetyl-lactosamine) on normal and leukaemic human haemopoietic cells: modulation by neuraminidase treatment ⬇️

scientific article published on December 1, 1984

Expression of Tie-2 and Other Receptors for Endothelial Growth Factors in Acute Myeloid Leukemias Is Associated with Monocytic Features of Leukemic Blasts

scientific article published on 19 April 2007

Expression of an accessory cell phenotype by hairy cells during lymphocyte colony formation in agar culture

scientific article published on 01 January 1983

Expression of c-fos in human normal and neoplastic monocyte-macrophage differentiation

scientific article published on 01 January 1987

Expression of transferrin receptors: differential regulatory mechanisms in monocytes-macrophages versus other hemopoietic cells

scientific article published on 01 January 1987

Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.

scientific article

Extrachromosomal human immunodeficiency virus type 1 DNA forms in fresh peripheral blood lymphocytes and in two interleukin-2-independent T cell lines derived from peripheral blood lymphocytes of an asymptomatic seropositive subject

scientific article

Fetal hemoglobin chemical inducers for treatment of hemoglobinopathies.

scientific article published on 15 November 2008

Fetal hemoglobin synthesis in culture of early erythroid precursors (BFU-E) from the blood of normal adults

scientific article published on 01 March 1980

Fetal to adult hemoglobin switch in cultures of early erythroid precursors from human fetuses and neonates

scientific article published on January 1979

Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors

article

Genetic Alterations in Renal Cancers: Identification of The Mechanisms Underlying Cancer Initiation and Progression and of Therapeutic Targets

scientific article published on 29 July 2020

Genetic Alterations of Metastatic Colorectal Cancer

scientific article published on 13 October 2020

Genetic heterogeneity of "normal" human erythrocyte glucose-6-phosphate dehydrogenase: an isoelectrophoretic polymorphism ⬇️

scientific article published on February 1, 1979

Genetic regulation of gamma gene expression: study of the interaction of beta-thalassemia with heterocellular HPFH

scientific article published on 01 January 1981

HLA antigens on human hemopoietic progenitors during embryonic-fetal life: expression and in vitro modulation.

scientific article published on October 1986

Hb switching in neonatal cultures. Increase of Hb A synthesis in presence of an erythroid potentiating activity (EPA)

scientific article published on 01 February 1982

HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose dexamethasone.

scientific article published on 7 November 2002

Hemin regulates the expression of transferrin receptors in human hematopoietic cell lines

scientific article published on 01 August 1982

Hemoglobin expression in clones of K562 cell line

scientific article published on 01 January 1982

Hemoglobin synthesis in 7-day and 14-day-old erythroid colonies from the bone marrow of normal individuals

scientific article published on 01 January 1980

Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise

scientific article published on 6 May 2010

High Dose-Intense Chemotherapy Alone or in Combination with Interleukin-2 for Small Cell Lung Cancer: A Pilot Study

scientific article published in January 1994

High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.

scientific article published on 11 April 2009

Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells

scientific journal article

Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors

scientific article (publication date: 15 June 2002)

Human cord blood-derived hemogenic endothelium generates mast cells

scientific article published on 15 November 2014

Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium

scientific article

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta)

scientific article published on 01 January 1988

Hypereosinophilia during 2-chlorodeoxyadenosine treatment for hairy cell leukaemia

scientific article published on 01 February 1996

IL-2 induces the release of secondary cytokines which stimulate the cytotoxic activity of either NK or CD8+ lymphocytes

scientific article published on 01 February 1991

IL-6, M-CSF and IAP cytokines in ovarian cancer: simultaneous assessment of serum levels

scientific article published on 01 October 1999

Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: Focus on DNA repair genes.

scientific article published on 21 September 2006

Identification of the hemangioblast in postnatal life

scientific article published on 01 November 2002

Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations.

scientific article

Immunophenotypic features of acute myeloid leukemias overexpressing the interleukin 3 receptor alpha chain.

scientific article published in August 2004

Impaired myelopoiesis in mice devoid of interferon regulatory factor 1.

scientific article published in November 2004

In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation

scientific article published on 15 December 2005

Induction of (2'-5') oligoadenylate synthetase activity during granulocyte and monocyte differentiation

scientific article published on July 1985

Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes

scientific article published on 31 January 2006

Inhibition of insulin receptor binding by A23187: synergy with phorbol esters

scientific article

Inhibition of insulin receptor binding by phorbol esters.

scientific article published in December 1982

Inhibition of lymphocyte blastogenic response in healthy donors treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): possible role of lactoferrin and interleukin-1 receptor antagonist

scientific article published on 01 September 1997

Inhibition of transferring binding and iron uptake of hematopoietic cell lines by phorbol esters.

scientific article published in January 1984

Interferon regulatory factor-2 drives megakaryocytic differentiation

scientific article published on January 2004

Interferons and the differentiation of Friend cells.

scientific article

Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS-related tyrosine kinase 3 receptor.

scientific article

Interleukin-2-dependent long-term cultures of low-density lymphocytes allow the proliferation of lymphokine-activated killer cells with natural killer, Ti gamma/delta or TNK phenotype

scientific article published in January 1990

Interleukin-6 serum levels in patients with gynecological tumors

scientific article published in May 1994

Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias

scientific article published on 26 August 2020

K562 cells induced to differentiate by phorbol ester tumor promotors resist NK lysis

scientific article published on 01 September 1984

Leukemia stem cells

scientific article published on 25 November 2010

Long-term culture of human LAK cells ⬇️

scientific article published on February 1, 1991

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells

scientific article published on 27 July 2018

M4 and M5 acute myeloid leukaemias display a high sensitivity to Bortezomib-mediated apoptosis

scientific article published in October 2007

Mannoprotein-induced anti-U937 cell cytotoxicity in peripheral blood mononuclear cells from uninfected or HIV-infected subjects: role of interferon-gamma and tumor necrosis factor-alpha

scientific article published on December 1993

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation

scientific article published on 21 September 2017

Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells

scientific article published on 20 November 2017

Methylation damage response in hematopoietic progenitor cells.

scientific article published on 15 May 2007

MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias

scientific article published on 24 June 2011

MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.

scientific article

MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation

scientific article published on 24 June 2007

MicroRNAs expressed in hematopoietic stem/progenitor cells are deregulated in acute myeloid leukemias

scientific article published on 21 January 2015

Modulation by growth factors of the expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chain beta c.

scientific article published on August 2002

Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation

scientific article

Molecular mechanisms regulating the synthesis of transferrin receptors and ferritin in human erythroleukemic cell lines

scientific article

Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts

article

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

scientific article published in Nature

Neonatal jaundice and severity of glucose-6-phosphate dehydrogenase deficiency in Sardinian babies

scientific article published on 01 November 1987

New genetic variants of glucose 6-phosphate dehydrogenase (G6PD) in Italy

scientific article published on 01 May 1981

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells

scientific article published in February 2018

Overexpression of Ets-1 in human hematopoietic progenitor cells blocks erythroid and promotes megakaryocytic differentiation.

scientific article published on 18 November 2005

Oxidative stress and hypoxia in normal and leukemic stem cells

scientific article published on 11 May 2016

Oxidative stress and transferrin receptor recycling

scientific article published on January 1993

Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular trafficking.

scientific article published in May 1998

PCR analysis of HIV-1 sequences and differential immunological features in seronegative and seropositive haemophiliacs

scientific article

PLZF-mediated control on VLA-4 expression in normal and leukemic myeloid cells.

scientific article

PLZF-mediated control on c-kit expression in CD34(+) cells and early erythropoiesis.

scientific article

PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response

scientific article published on 07 April 2016

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

scientific article

Phorbol esters inhibit the binding of low-density lipoproteins (LDL) to U-937 monocytelike cells

scientific article published on December 1984

Platelet formation: a link between apoptosis and differentiation

scientific article published on 01 August 2002

Podocalyxin is expressed in normal and leukemic monocytes

scientific article published on 23 October 2006

Post-transcriptional regulation of transferrin receptor mRNA by IFNγ ⬇️

scientific article published on June 25, 1992

Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome

scientific article

Primary ovarian cancer cells are sensitive to the proaptotic effects of proteasome inhibitors.

scientific article

Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients

scientific article published on 26 February 2016

Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis.

scientific article published on April 2007

Pure human hematopoietic progenitors: direct inhibitory effect of transforming growth factors-beta 1 and -beta 2.

scientific article published on January 1991

Reactivation of HbF synthesis in normal adult erythroid bursts by IL-3.

scientific article

Regulation of Expression of Ferritin H-chain and Transferrin Receptor by Protoporphyrin IX

scientific article published on 01 December 1997

Regulation of transferrin receptor 2 in human cancer cell lines

scientific article

Relation of Various Plasma Growth Factor Levels in Patients With Stable Angina Pectoris and Total Occlusion of a Coronary Artery to the Degree of Coronary Collaterals

scientific article published on 20 December 2005

Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels

scientific article

Role of Ets-1 in erythroid differentiation

scientific article

Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation

scientific article published in November 2002

Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells

scientific article published on August 2005

Role of stem cell factor in the reactivation of human fetal hemoglobin.

scientific article

SCF-mediated γ-globin gene expression in adult human erythroid cells is associated with KLF1, BCL11A and SOX6 down-regulation

article

STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules

scientific article published on 01 July 1999

Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines

scientific article (publication date: 2014)

Specific modulation of surface receptors in J.774 macrophages by anchorage.

scientific article published in June 1987

Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins

scientific article published on 13 March 2003

Stromal cell-derived factor 1alpha increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells

scientific article published on 01 May 2001

Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes

scientific article published on 14 July 2005

TGF beta induces a sustained c-fos expression associated with stimulation or inhibition of cell growth in EL2 or NIH 3T3 fibroblasts

scientific article published on February 1988

Target structure for natural killer cells: evidence against a unique role for transferrin receptor

scientific article published on April 1984

Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.

scientific article published on 26 July 2015

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.

scientific article published on 26 June 2008

Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

scientific article published on 28 December 2017

Terminal megakaryocytic differentiation of TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RARalpha fusion protein

scientific article published on 01 April 1998

TfR2 expression in human colon carcinomas

scientific article

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

scientific article published on 17 October 2006

The EL2 rat fibroblasts line: differential effects of growth factors (EGF, PDGF, FGF, TPA and TGF beta) on cell proliferation and c-fos expression

scientific article published on 01 January 1987

The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias

scientific article published on 9 July 2013

The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts

scientific article

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

scientific article published on August 1993

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.

scientific article

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer ⬇️

scientific article published on March 27, 2012

The iron-chelating agent picolinic acid enhances transferrin receptors expression in human erythroleukaemic cell lines

scientific article published on 01 July 1985

The origin of human B and T cells from multipotent stem cells: a study of the Tn syndrome

scientific article published on 01 April 1983

The synergistic effect of simultaneous addition of retinoic acid and vitamin D3 on the in-vitro differentiation of human promyelocytic leukemia cell lines could be efficiently transposed in vivo

scientific article

Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing

scientific article

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

scientific article published on 18 October 2013

Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation

scientific article

Transferrin binding to K562 cell line. Effect of heme and sodium butyrate induction

scientific article published on 01 August 1982

Transferrin receptor 2 is frequently expressed in human cancer cell lines

article

Transferrin receptor 2 protein is not expressed in normal erythroid cells

scientific article published on August 2004

Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes

scientific article published on May 1992

Triterpenoids as new promising anticancer drugs.

scientific article

Tumor necrosis factor alpha is a powerful apoptotic inducer in lymphoid leukemic cells expressing the P-170 glycoprotein

scientific article published on July 1996

Vascular endothelial growth factors in cardiovascular medicine.

scientific article published on December 2008

Zinc modulates c-Myc/Mad1 balance in human leukemia cells

scientific article published on 01 January 2003

deltaN-p73 is a transcriptional target of the PML/RARalpha oncogene in myeloid differentiation

scientific article published on 10 August 2007

miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.

scientific article published on 26 June 2017

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

scientific article

miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.

scientific article published on 10 September 2012

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