List of works - Stephen H. McLaughlin

A single purification procedure for the major resident proteins of the ER lumen: endoplasmin, BiP, calreticulin and protein disulfide isomerase

scientific article published on 01 August 1994

A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases

scientific article published on 03 October 2019

An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

scientific article published on 18 September 2019

Architecture of the CBF3-centromere complex of the budding yeast kinetochore

scientific article published on 26 November 2018

Atomic structure of the APC/C and its mechanism of protein ubiquitination

scientific article

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

scientific article published in July 2004

Cloning and expression of active domains of human protein disulphide isomerase

scientific article published on 01 February 1995

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs

scientific article

Crenactin forms actin-like double helical filaments regulated by arcadin-2.

scientific article published on 17 November 2016

Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli

scientific article published on 24 November 2015

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

scientific article published on 31 October 2013

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

scientific article published on 18 February 2014

Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo

scientific article published on 27 June 2011

Evolution of oligomeric state through allosteric pathways that mimic ligand binding

scientific article

Experimental and theoretical analyses of the domain architecture of mammalian protein disulphide-isomerase

scientific article published on 01 March 1998

Folding and assembly of type X collagen mutants that cause metaphyseal chondrodysplasia-type schmid. Evidence for co-assembly of the mutant and wild-type chains and binding to molecular chaperones.

scientific article

Folding and stability of the ligand-binding domain of the glucocorticoid receptor

scientific article

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

scientific article published in November 2004

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

scientific article

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives

scientific article

Molecular architecture and mechanism of the anaphase-promoting complex

scientific article

Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1

scientific article published on 19 May 2021

Molecular recognition in procollagen chain assembly

scientific article published on February 1998

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

scientific article published on 16 March 2011

Protein disulfide-isomerase

scientific article published on 01 January 1995

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

scientific article

Stimulation of the weak ATPase activity of human hsp90 by a client protein

scientific article

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

scientific article

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

scientific article published on 4 June 2015

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

scientific article published on 29 June 2016

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

scientific article

Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae

scientific article published on February 2017

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing

scientific article published on 09 July 2019

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state

scientific article published on 10 July 2020

Structure of the SAS-6 cartwheel hub from Leishmania major

scientific article

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

scientific article

Synthetic genetic polymers capable of heredity and evolution

scientific article

Target-induced clustering activates Trim-Away of pathogens and proteins

scientific article published on 25 February 2021

The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase

scientific article published on 18 December 2016

The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

scientific article

The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity

scientific article

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes

scientific article

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

scientific article published on 15 December 2005

The refolding of hen egg white riboflavin-binding protein: effect of protein disulphide isomerase on the reoxidation of the reduced protein

scientific article published on October 1995

The structure of bactofilin filaments reveals their mode of membrane binding and lack of polarity

scientific article published on 09 September 2019

Thiol-independent interaction of protein disulphide isomerase with type X collagen during intra-cellular folding and assembly

scientific journal article

List of works by Stephen H. McLaughlin

A single purification procedure for the major resident proteins of the ER lumen: endoplasmin, BiP, calreticulin and protein disulfide isomerase

A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases

An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

Architecture of the CBF3-centromere complex of the budding yeast kinetochore

Atomic structure of the APC/C and its mechanism of protein ubiquitination

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

Cloning and expression of active domains of human protein disulphide isomerase

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs

Crenactin forms actin-like double helical filaments regulated by arcadin-2.

Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo

Evolution of oligomeric state through allosteric pathways that mimic ligand binding

Experimental and theoretical analyses of the domain architecture of mammalian protein disulphide-isomerase

Folding and assembly of type X collagen mutants that cause metaphyseal chondrodysplasia-type schmid. Evidence for co-assembly of the mutant and wild-type chains and binding to molecular chaperones.

Folding and stability of the ligand-binding domain of the glucocorticoid receptor

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives

Molecular architecture and mechanism of the anaphase-promoting complex

Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1

Molecular recognition in procollagen chain assembly

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

Protein disulfide-isomerase

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

Stimulation of the weak ATPase activity of human hsp90 by a client protein

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state

Structure of the SAS-6 cartwheel hub from Leishmania major

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

Synthetic genetic polymers capable of heredity and evolution

Target-induced clustering activates Trim-Away of pathogens and proteins

The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase

The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

The refolding of hen egg white riboflavin-binding protein: effect of protein disulphide isomerase on the reoxidation of the reduced protein

The structure of bactofilin filaments reveals their mode of membrane binding and lack of polarity

Thiol-independent interaction of protein disulphide isomerase with type X collagen during intra-cellular folding and assembly