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List of works by Sander Kersten

A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.

scientific article published on 23 February 2011

ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract

scientific article

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

scientific article

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

scientific article (publication date: 6 October 2011)

ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

scientific article published on 18 July 2017

Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

scientific article published on 6 March 2012

Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis

scientific article

Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice.

scientific article published on 21 September 2010

Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).

scientific article

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

scientific article

Angiopoietin-Like Proteins and Lipid Metabolism

Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration

scientific article

Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing

scientific article

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

scientific article published on 31 March 2016

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors

scientific article

Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice

scientific article (publication date: September 2014)

Angiopoietin-like 4: a decade of research

scientific article

Angiopoietin-like protein 4 is differentially regulated by glucocorticoids and insulin in vitro and in vivo in healthy humans

scientific article published on 12 September 2012

Angiopoietin-like-4 is a potential angiogenic mediator in arthritis

scientific article

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

scientific article

Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion

scientific article

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

scientific article (publication date: November 2007)

Auto-silencing by the retinoid X receptor 1 1Edited by M. Yaniv

scientific article published on 01 November 1998

Bioactivity screening and mass spectrometric confirmation for the detection of PPARδ agonists that increase type 1 muscle fibres

scientific article published on 28 November 2013

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

scientific article published on 28 October 2014

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

scientific article published on 15 June 2016

Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids

scientific article

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

scientific article

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

scientific article published on 17 November 2012

Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome

scientific article

Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

scientific article

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers

scientific article published on 04 September 2020

Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice

scientific article published on 27 September 2011

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling

scientific article

Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.

scientific article

Design guidelines for the development of digital nutrigenomics learning material for heterogeneous target groups.

scientific article published on March 2007

Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart

article

Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes.

scientific article published on 2 January 2013

Dropping liver fat droplets

scientific article published on 01 August 2009

Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.

scientific article

Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c

scientific article

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

scientific article published in November 2015

Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects

scientific article published on 19 June 2015

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist

scientific journal article

Erratum: Corrigendum: IL-37 protects against obesity-induced inflammation and insulin resistance

scientific article published on 12 January 2015

Exercise training improves liver steatosis in mice

scientific article published on 7 August 2015

Exploration of PPAR functions by microarray technology--a paradigm for nutrigenomics

scientific article published on 2 June 2007

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

scientific article (publication date: 18 March 2014)

Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites

scientific article published on 15 April 2017

Fight fat with DGAT.

scientific article published on 28 January 2011

G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase

scientific article published on 13 August 2012

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

scientific article published on 23 January 2016

Genome-wide analysis of PPARα activation in murine small intestine

scientific article published on 10 April 2007

Global profiling of the muscle metabolome: method optimization, validation and application to determine exercise-induced metabolic effects

Hepatic genome-wide expression of lipid metabolism in diet-induced obesity rats treated with cocoa polyphenols

Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion

scientific article

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.

scientific article

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.

scientific article published on 11 January 2018

IL-37 protects against obesity-induced inflammation and insulin resistance

scientific article published on 3 September 2014

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

scientific article

Identification of human exercise-induced myokines using secretome analysis

article

In vivo activation of PPAR target genes by RXR homodimers

scientific article

Individual subunits of heterodimers comprised of retinoic acid and retinoid X receptors interact with their ligands independently

scientific article

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

scientific article

Integrated physiology and systems biology of PPARα

scientific article

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice.

scientific article published in May 2018

Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity

scientific article published in February 2010

LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux

scientific article

Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue

scientific article

Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity

scientific article published on 09 July 2014

Mechanisms of gene regulation by fatty acids

scientific article

Mechanisms of inflammatory responses in obese adipose tissue

scientific article

Mechanisms of nutritional and hormonal regulation of lipogenesis

scientific article

Metabolic switching of human myotubes is improved by n-3 fatty acids

scientific article

Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial

scientific article published on 27 May 2008

Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1.

scientific article published on 06 January 2010

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

scientific article published on 22 May 2017

Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols

scientific article

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice

scientific article published on 12 December 2015

Natural killer T cells in adipose tissue prevent insulin resistance

scientific article

No effect of 25-hydroxyvitamin D supplementation on the skeletal muscle transcriptome in vitamin D deficient frail older adults.

scientific article published on 28 May 2019

Nutrigenomics: goals and strategies.

scientific article

Omega-3 long-chain fatty acids strongly induce angiopoietin-like 4 in humans

scientific article published on 14 January 2013

On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor

scientific article published on October 1995

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

scientific journal article

Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

scientific article

PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism

scientific article published on 18 April 2014

PPARS and Obesity

scientific article published on January 2007

PPARalpha and dyslipidemia

scientific article published on 2 June 2007

PPARalpha governs glycerol metabolism

scientific journal article

PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation

scientific article published on 20 November 2007

PPARgamma activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding.

scientific article

PPARs, Obesity, and Inflammation

scientific article

PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference

scientific article

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase

scientific article published on 13 July 2012

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels

scientific article

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

scientific article

Peroxisome Proliferator-Activated Receptor α Protects against Obesity-Induced Hepatic Inflammation

scientific article published on 08 March 2007

Peroxisome proliferator activated receptors and lipoprotein metabolism

scientific article published on January 2008

Peroxisome proliferator activated receptors and obesity

scientific article

Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.

scientific article published on 14 March 2009

Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression

scientific article published on 15 December 2005

Peroxisome proliferator-activated receptor alpha target genes

scientific article

Peroxisome proliferator-activated receptor alpha target genes.

scientific article published on 26 September 2010

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver

scientific article published on 5 October 2009

Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD

scientific article published on 25 April 2007

Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.

scientific article

Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).

scientific article

Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain

scientific article

Physiological regulation of lipoprotein lipase

scientific article published on 08 April 2014

Plasma mannose-binding lectin is stimulated by PPARα in humans

scientific article published on 03 January 2012

Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome

scientific article

Potential mediators linking gut bacteria to metabolic health: a critical view

scientific article published on 15 July 2016

Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis

scientific article published on 27 January 2010

Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha

scientific article

Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle.

scientific article

RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes

scientific article published on 18 August 2021

Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity

scientific article

Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury

scientific article

Regulation of Lipogenic Genes in Obesity

article

Regulation of Nutrient Metabolism and Inflammation ⬇️

scientific article published on January 1, 2010

Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors

scientific article published on 19 July 2017

Regulation of lipid metabolism by angiopoietin-like proteins

scientific article published on 28 March 2016

Regulation of lipid metabolism via angiopoietin-like proteins

scientific article

Regulation of lipoprotein lipase by Angptl4.

scientific article

Regulation of triglyceride metabolism by Angiopoietin-like proteins

scientific article published on 25 October 2011

Reply:

Retinoid X receptor alpha forms tetramers in solution

scientific article

Retraction notice to “Peroxisome Proliferator-Activated Receptor α Controls Hepatic Heme Biosynthesis Through ALAS1” J. Mol. Biol. 388/2 (2010) 225–238

scientific article published on 01 November 2010

Role of Ligand in Retinoid Signaling. 9-cis-Retinoic Acid Modulates the Oligomeric State of the Retinoid X Receptor

scientific article published on 01 October 1995

Roles of PPARs in health and disease.

scientific article

Saturated fatty acids and snoRNAs: partners in crime

scientific article published in July 2011

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

scientific article published on 22 January 2014

Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

scientific article

Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ

scientific article

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

scientific article

Stabilizing lipoprotein lipase

scientific article published on 6 August 2009

Steroid and nuclear receptors. Villefranche-sur-Mer, France, May 25-27, 1999.

scientific article

Sulfonylureas and Glinides Exhibit Peroxisome Proliferator-Activated Receptor Activity: A Combined Virtual Screening and Biological Assay Approach

The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue

scientific article

The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state

scientific article published on May 1997

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism

scientific journal article

The Effects of Long- or Medium-Chain Fat Diets on Glucose Tolerance and Myocellular Content of Lipid Intermediates in Rats

scientific article published on 01 July 2010

The G0/G1 switch gene 2 is a novel PPAR target gene.

scientific article

The Genetics of Dyslipidemia--When Less Is More

scientific article published on 2 March 2016

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

scientific article published on 26 December 2006

The PPARgamma ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARgamma in the subcutaneous adipose tissue

scientific article published on 4 January 2008

The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment

scientific article

The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity

scientific article

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

scientific article published in September 2008

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

scientific article

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

scientific article published on December 2010

The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy)

scientific article published on 16 April 2012

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

scientific journal article

The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.

scientific article

The role and regulation of the peroxisome proliferator activated receptor alpha in human liver

scientific article published on 7 January 2017

The role of the gut microbiota in metabolic health

scientific article published on 28 April 2015

The search for exercise factors in humans

scientific article

The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor

scientific article published in November 1997

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice.

scientific article published on 7 June 2018

Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

scientific article published on 11 March 2019

Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver.

scientific article published on 15 December 2009

Transcriptomic signatures of peroxisome proliferator-activated receptor α (PPARα) in different mouse liver models identify novel aspects of its biology

scientific article

Triglyceride Metabolism under Attack

scientific article published in June 2017

Wageningen Nutritional Sciences Forum 2009: Too much, too little

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