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List of works by Monica Fedele

A mutated p53 gene alters thyroid cell differentiation.

scientific article published on November 1995

A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor

scientific article

A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

scientific article published on 19 December 2016

A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas

scientific article published on 11 September 2003

Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

scholarly article

Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.

scientific article

Animal Models of Human Pathology ⬇️

scientific article published on June 30, 2011

Animal Models of Human Pathology 2012 ⬇️

scientific article published on August 30, 2012

Animal Models of Human Pathology 2014.

scientific article published on 12 July 2015

Animal Models of Human Pathology 2016.

scientific article

Animal models of human pathology 2013

scientific article published on 20 February 2014

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

scientific article published on 10 October 2015

Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers

scientific article

B-RAF mutations are a rare event in pituitary adenomas

scientific article published on 01 January 2007

CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

scientific article

CBX7 is a tumor suppressor in mice and humans

scientific article

Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein

scientific journal article

Complementary actions of dopamine D2 receptor agonist and anti-vegf therapy on tumoral vessel normalization in a transgenic mouse model.

scientific article published on 2 February 2017

Critical role of the HMGA2 gene in pituitary adenomas

scientific article

Detection of high-mobility group proteins A1 and A2 represents a valid diagnostic marker in post-pubertal testicular germ cell tumours

article

Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

scientific article

Dual Oncogenic/Anti-Oncogenic Role of PATZ1 in FRTL5 Rat Thyroid Cells Transformed by the Oncogene

article

E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

scientific article published on 17 August 2006

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene

scientific article published in March 2013

Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement

scientific article published on February 2002

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

scientific article published in October 1997

FRA-1 expression in hyperplastic and neoplastic thyroid diseases

scientific article published on 01 November 2000

HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas

article

HMGA and cancer

scientific article published on January 2010

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

scientific article published on 21 February 2011

HMGA1 and HMGA2 protein expression in mouse spermatogenesis

scientific journal article

HMGA1 protein expression sensitizes cells to cisplatin-induced cell death

scientific article published on October 2005

HMGA1 protein is a novel target of the ATM kinase

scientific article published on 8 September 2008

HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression

scientific article

HMGA2 cooperates with either p27(kip1) deficiency or Cdk4(R24C) mutation in pituitary tumorigenesis.

scientific article published on 20 November 2017

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

scientific article

HMGA2: A pituitary tumour subtype-specific oncogene?

scientific article published on 27 March 2010

Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice

scientific article published in March 2006

High level expression of the HMGI (Y) gene during embryonic development

scientific article published in December 1996

High mobility group A-interacting proteins in cancer: focus on chromobox protein homolog 7, homeodomain interacting protein kinase 2 and PATZ

article

High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.

scientific article published in January 2001

High-mobility group A1 proteins are overexpressed in human leukaemias

scientific article published on May 2003

High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).

scientific article published on July 2005

Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis

scientific article published on 26 December 2007

Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype

scientific article

Hot Topics in Endocrine and Endocrine-Related Diseases

Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins

scientific article published on April 1996

IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1.

scientific article

Identification and Characterization of a Novel RING-Finger Gene (RNF4) Mapping at 4p16.3 ⬇️

scientific article published on January 15, 1998

Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation

scientific article published on August 2004

Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice

scientific article published on 4 March 2009

Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo

scientific article published in July 1998

Involvement of the HMGIY gene in a microfollicular adenoma of the thyroid

article

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

scientific article published on 29 May 2005

Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation

scientific article published on 17 June 2003

Loss of One or Two PATZ1 Alleles Has a Critical Role in the Progression of Thyroid Carcinomas Induced by the RET/PTC1 Oncogene.

scientific article published on 27 March 2018

MicroRNAs in pituitary tumours

Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

scientific article

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

scientific article

Non-Histone Chromatin Proteins

Novel Aptamers Selected on Living Cells for Specific Recognition of Triple-Negative Breast Cancer

scientific article published on 12 March 2020

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications.

scientific article

Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

scientific article published on 26 June 2001

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

scientific article

PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription

scientific article

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

scientific article published on 11 October 2019

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration

scientific article published on March 2015

PATZ1 downregulation promotes proliferation and migration in Ras-driven thyroid transformation

PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas

scientific article published on August 2016

PATZ1 gene has a critical role in the spermatogenesis and testicular tumours

scientific journal article

PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context

scientific article published on 12 December 2013

PATZ1 is a new prognostic marker of glioblastoma associated with the stem-like phenotype and enriched in the proneural subtype.

scientific article published on 25 July 2017

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells

scientific article published on 29 April 2016

PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis

scientific article

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes

scientific journal article

Pituitary Adenoma: Role of HMGA Proteins

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

scientific article published on 04 June 2019

RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors

scientific article

Regulation of microRNA expression by HMGA1 proteins

scientific article

Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes

scientific article published on June 1999

Role of the high mobility group A proteins in the regulation of pituitary cell cycle

scientific article published on 10 March 2010

Roles of HMGA proteins in cancer

scientific article published on December 2007

SOM230, A New Somatostatin Analogue, Is Highly Effective in the Therapy of Growth Hormone/Prolactin-Secreting Pituitary Adenomas

scientific article published on 01 May 2007

Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles

scientific article published in 2022

Simian virus 40-like DNA sequences in human papillary thyroid carcinomas ⬇️

scientific article published on February 5, 1998

Status and expression of thep16INK4 gene in human thyroid tumors and thyroid-tumor cell lines

article

Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2 ⬇️

scientific article published on November 1, 2003

TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities

scientific article published on 13 November 2018

Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFRβ aptamer

scientific article published on 06 October 2018

Targeting ofPATZ1by miR-29b is a downstream effect of oncogenic Ras signalling in thyroid cells

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas

scientific article

The Genetics of Pituitary Adenomas

article

The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake

scientific article

The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas

article

The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.

scientific article

The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement

scientific article published on 24 November 2017

The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation

scientific article published on 07 April 2021

The Tumor Suppressive Role of PATZ1 in Thyroid Cancer: A Matter of Epithelial-Mesenchymal Transition

article published in 2016

The dosage of Patz1 modulates reprogramming process.

scientific article

The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.

scientific article

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

scientific article

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.

scientific article

Transcriptional and post-transcriptional regulation of transmembrane protein 132A.

scientific article published on 30 April 2015

Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.

scientific article published in May 2005

Translational regulation of a novel testis-specific RNF4 transcript

scientific article

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

scientific article published on July 1998

Tumor suppressor activity of CBX7 in lung carcinogenesis

scientific article published on 15 May 2012

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines

scientific article published on 01 October 1995

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