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List of works by John P. Cooke

A Novel Mechanism for Pulmonary Arterial Hypertension? ⬇️

scientific article published on September 23, 2003

A central role for nicotinic cholinergic regulation of growth factor-induced endothelial cell migration.

scientific article published on 2 November 2006

A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease.

scientific article

A compendium on peripheral arterial disease

scientific article

A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis

scientific article

A matrix micropatterning platform for cell localization and stem cell fate determination.

scientific article

A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide

scientific article

A novel bioluminescent tumor model of human renal cancer cell lines: an in vitro and in vivo characterization

scientific article published on June 2007

A peculiar result and a fanciful hypothesis regarding L-arginine

scientific article

A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease.

scientific article

A validated biomarker panel to identify peripheral artery disease

scientific article published on 19 October 2012

ADMA increases arterial stiffness and decreases cerebral blood flow in humans

scientific article published on 29 June 2006

ADMA regulates angiogenesis: genetic and metabolic evidence

scientific article published in February 2005

ADMA: an emerging cardiovascular risk factor

scientific article published in July 2005

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

scientific article

Abnormal cardiovascular response to exercise in patients with peripheral arterial disease: Implications for management

scientific article published on 01 December 2005

Activation of innate immunity is required for efficient nuclear reprogramming

scientific article

Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection.

scientific article

Aligned nanofibrillar collagen regulates endothelial organization and migration.

scientific article published on September 2012

Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema.

scientific article published on 07 June 2016

Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis

scientific article published on 17 June 2015

An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes

scientific article

Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial

scientific article published on 11 August 2003

Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits.

scientific article published in November 1996

Assessing endothelial vasodilator function with the Endo-PAT 2000.

scientific article

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

scientific article published on 23 December 2011

Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury

scientific article published on 05 May 2007

Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study

scientific article published in April 2007

Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase

scientific article

Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus

scientific article

Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.

scientific article

Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies

scientific article

Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration

scientific article published in April 2012

Biomarkers of peripheral arterial disease.

scientific article

Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial

scientific article

Bone marrow characteristics associated with changes in infarct size after STEMI: a biorepository evaluation from the CCTRN TIME trial.

scientific article

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.

scientific article

Building a partnership between vascular medicine and vascular surgery: a coalition for the future of vascular care

scientific article published on May 1996

Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma.

scientific article

Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.

scientific article published on 19 April 2018

Cardiovascular effects of L-arginine

scientific article published on January 1998

Cardiovascular effects of exercise: role of endothelial shear stress

scientific article published on December 1996

Cell-free production of transducible transcription factors for nuclear reprogramming.

scientific article

Changes in coronary arterial dimensions early after cardiac transplantation

scientific article published on 01 March 2007

Characterization of a fluorescent probe for imaging nitric oxide.

scientific article published on 11 December 2013

Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?

scientific article

Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor.

scientific article

Chronic exposure to nicotine impairs cholinergic angiogenesis

scientific article published on 24 September 2009

Clinical and socioeconomic factors associated with unrecognized peripheral artery disease

scientific article published on 28 May 2014

Concurrent generation of functional smooth muscle and endothelial cells via a vascular progenitor

scientific article

Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis

scientific article published in 2023

Critical determinants of limb ischemia

scientific article published on July 2008

DDAH says NO to ADMA

scientific article published on July 2011

DDAH: a target for vascular therapy?

scientific article

Decongestive lymphatic therapy for patients with cancer-related or primary lymphedema

scientific article

Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes.

scientific article

Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay

scientific article published in January 2004

Development of a Dimethylarginine Dimethylaminohydrolase (DDAH) Assay for High-Throughput Chemical Screening ⬇️

scientific article published on March 29, 2012

Development of pluripotent stem cells for vascular therapy

scientific article published on 23 February 2012

Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia

scientific article published on 23 February 2004

Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans.

scientific article published in March 1997

Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit

scientific article published in February 1994

Dietary nitrate, nitric oxide, and restenosis

scientific article published on 23 March 2011

Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.

scientific article published on September 2007

Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity

scientific article

Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury

scientific article published on 23 February 2007

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.

scientific article

Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis

scientific article published in February 2004

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

scientific article

Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?

scientific article published on 04 July 2009

Does leptin cause vascular disease?

scientific article published on 01 October 2002

Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome

scientific article published on 14 August 2019

Effect of cyclosporine on chronic graft vascular disease in a rat cardiac isograft model

scientific article published on 01 June 1998

Effect of local delivery of L-arginine on in-stent restenosis in humans

scientific article published on February 2002

Effect of physical activity assessment on prognostication for peripheral artery disease and mortality

scientific article published on 31 January 2015

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.

scientific article published on September 2013

Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro

scientific article

Effects of growth factors and L-arginine on ischemic skin flaps in rats

scientific article

Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion

scientific article

Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease

scientific article

Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases

scientific article published in November 2002

Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity

scientific article published on June 2000

Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.

scientific article published on 11 August 2003

Endothelial nicotinic acetylcholine receptors and angiogenesis.

scientific article published on October 2008

Endothelial progenitor cells participate in nicotine-mediated angiogenesis

scientific article published on 28 November 2006

Endovascular correction of cerebrovenous anomalies in multiple sclerosis: A retrospective review of an uncontrolled case series ⬇️

scientific article published on April 10, 2012

Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease

scientific article published on 6 October 2012

Exercise patterns and cardiovascular fitness of patients with peripheral arterial disease

scientific article published in December 2004

Extensive characterization of the human DDAH1 transgenic mice

scientific article published on 8 August 2009

FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats

scientific article

Fli1<sup>+</sup> cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis

scientific article published on 01 August 2021

Flow, NO, and atherogenesis

scientific article

Flow-responsive remodeling after angioplasty is enhanced by high cholesterol diet. Prevention with pyrrolidine dithiocarbamate

scientific article

Gender differences in perception of PAD: a pilot study.

scientific article published in May 2003

Gene transfer of nitric oxide synthase: effects on endothelial biology

scientific article published on October 1999

Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.

scientific article

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

scientific article published on 2 February 2012

Genetics of peripheral artery disease

scientific article published on June 2012

High-dose vitamin A therapy for Darier's disease

scientific article published on 01 November 1982

Homocysteine impairs coronary microvascular dilator function in humans

scientific article published in September 2002

Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor

scientific article published in August 2005

How May Proton Pump Inhibitors Impair Cardiovascular Health?

scientific article published on 27 January 2016

Hypercholesterolemia impairs exercise capacity in mice

scientific article

Hypertension-enhanced monocyte adhesion in experimental atherosclerosis

scientific article published on 01 April 1996

Identification and Classification of Acute Cardiac Rejection by Intragraft Transcriptional Profiling ⬇️

scientific article published on May 9, 2011

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials

scientific article published on 23 November 2016

Imaging vascular nicotine receptors: a new window onto vascular disease

scientific article published in May 2012

In Memoriam of John T. Shepherd, MD, DSc.

scientific article published in January 2012

Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

scientific article published on 22 July 2011

Innate immunity and epigenetic plasticity in cellular reprogramming.

scientific article

Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia

scientific article

L-arginine supplementation in peripheral arterial disease: no benefit and possible harm

scientific article published on 25 June 2007

LIM Domain Only 2 Regulates Endothelial Proliferation, Angiogenesis, and Tissue Regeneration

scientific article published on 06 October 2016

Letter by Kielstein et al Regarding Article, “Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure”

scientific article published on 01 August 2006

Letter by Stuehlinger et al regarding article, "Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction".

scientific article

Limb hemodynamics are not predictive of functional capacity in patients with PAD

scientific article published on 01 November 2006

Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Endothelial Cells ⬇️

scientific article published on January 1, 2013

Low lifetime recreational activity is a risk factor for peripheral arterial disease

scientific article

Lymphangiogenesis: a potential new therapy for lymphedema?

scientific article published on 24 January 2012

Meal-induced increases in C-reactive protein, interleukin-6 and tumour necrosis factor α are attenuated by prandial + basal insulin in patients with Type 2 diabetes.

scientific article

Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.

scientific article published on April 2008

Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes

scientific article

MicroRNA and mechanisms of impaired angiogenesis in diabetes mellitus

scientific article published on 10 January 2011

Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia

scientific article published on 9 November 2006

Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow.

scientific article published on January 2014

Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine

scientific article published in July 2001

Modulating the vascular response to limb ischemia: angiogenic and cell therapies.

scientific article published on April 2015

Multifunctional in vivo vascular imaging using near-infrared II fluorescence

scientific article

Murine model of hindlimb ischemia

scientific article

NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL.

scientific article

Near-infrared II fluorescence for imaging hindlimb vessel regeneration with dynamic tissue perfusion measurement

scientific article

Nicotine and angiogenesis: a new paradigm for tobacco-related diseases.

scientific article published on January 2004

Nicotine promotes arteriogenesis

scientific article

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

scientific article

Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions

scientific article

Nitric oxide and angiogenesis

scientific article published on 01 May 2002

Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women

scientific article

Nitric oxide synthase: role in the genesis of vascular disease

scientific article published on January 1997

Nonbone Marrow-Derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia

article

Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis.

scientific article

Optimal ROS Signaling Is Critical for Nuclear Reprogramming.

scientific article

Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.

scientific article published on 6 December 2007

Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.

scientific article

Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.

scientific article published on 2 December 2011

PPARδ activation protects endothelial function in diabetic mice.

scientific article

Phase II clinical research design in cardiology: learning the right lessons too well: observations and recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN).

scientific article published on April 2013

Phytoestrogens and cardiovascular health.

scientific article

Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus

scientific article published in November 2001

Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease.

scientific article

Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis

scientific article published in August 2015

Postgraduate training in vascular medicine: proposed requirements and standards.

scientific article

Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication

scientific article

Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population

scientific article

Proton Pump Inhibitors Accelerate Endothelial Senescence

scientific article published on 10 May 2016

Proton pump inhibitors and vascular function: A prospective cross-over pilot study

scientific article

Psychophysiological and cortisol responses to psychological stress in depressed and nondepressed older men and women with elevated cardiovascular disease risk

scientific article published in July 2006

Randomized trial of AT-1015 for treatment of intermittent claudication. A novel 5-hydroxytryptamine antagonist with no evidence of efficacy

scientific article

Rationale and design for PACE: patients with intermittent claudication injected with ALDH bright cells

scientific article

Re: The American "board" of vascular medicine: questions and concerns

scientific article published on 01 May 2006

Relationship of asymmetric dimethylarginine and homocysteine to vascular aging in systemic lupus erythematosus patients

scientific article published in June 2010

Reply

Response to Letter Regarding Article "Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity"

scientific article published on 01 October 2015

Response to letters regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine".

scientific article published on April 2014

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming

scientific article published on 9 March 2017

SVMB presidential address. The time has come for vascular medicine

scientific article published on 01 November 2006

Second hand smoke stimulates tumor angiogenesis and growth

scientific article published in September 2003

Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden.

scientific article

Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization

scientific article published on December 2010

Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis

scientific article

Should we measure asymmetric dimethylarginine in patients with coronary artery disease?

scientific article published on 01 February 2007

Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature.

scientific article published on 26 January 2013

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association

scientific article

Statins have biphasic effects on angiogenesis

scientific article published in February 2002

Suboptimal intensity of risk factor modification in PAD.

scientific article published on May 2005

Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis

scientific article

T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease

scientific article published on 2 October 2006

Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat

scientific article published on 22 January 2016

Task force 11: training in vascular medicine and peripheral vascular catheter-based interventions endorsed by the Society for Cardiovascular Angiography and Interventions and the Society for Vascular Medicine

scientific article published on 01 January 2008

The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity

scientific article

The Society for Vascular Medicine: the first quarter century

scientific article published in February 2015

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model

scientific article

The emerging role of the thioredoxin system in angiogenesis

scientific article

The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds

scientific article published on 05 March 2013

The role of coronary angiography and coronary revascularization before noncardiac vascular surgery

scientific article published on 01 June 1995

The role of nicotine in the pathogenesis of atherosclerosis

scientific article published on February 2011

The use of machine learning for the identification of peripheral artery disease and future mortality risk

scientific article published on 3 June 2016

Therapeutic transdifferentiation: a novel approach for vascular disease.

scientific article published on March 2013

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.

scientific article published on 20 June 2008

Topical mecamylamine for diabetic macular edema

scientific article

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.

scientific article published on 13 September 2016

Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity

scientific article published on 30 October 2014

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

scientific article

Two cardiovascular risk factors in one? Homocysteine and its relation to glomerular filtration rate. A meta-analysis of 41 studies with 27,000 participants

scientific article published on 18 March 2008

Two decades of progress in vascular medicine.

scientific article

Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.

scientific article published on 03 July 2013

Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography ⬇️

scientific article published on March 15, 2013

Vascular compliance versus flow-mediated vasodilation: correlation with cardiovascular risk factors

scientific article published on 01 November 2005

Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature

scientific article

Vasoconstriction induced by ouabain in the canine coronary artery: contribution of adrenergic and nonadrenergic responses

scientific article published on 01 July 1988

Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status.

scientific article

nAChRs mediate human embryonic stem cell-derived endothelial cells: proliferation, apoptosis, and angiogenesis

scientific article

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