Search filters

List of works by Rolf Müller

-Acylated amino acid methyl esters from marine group bacteria ⬇️

scientific article published on 03 December 2018

2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside ⬇️

scientific article published on 09 June 2020

3-Hydroxy-3-Methylglutaryl-CoA-Like Synthases Direct the Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin A

scientific article published on 01 March 2007

3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.

scientific article published on September 2006

A "Motif-Oriented" Total Synthesis of Nannocystin Ax. Preparation and Biological Assessment of Analogues

scientific article published on 21 December 2017

A Highly Conjugated Dihydroxylated C28Steroid from a Myxobacterium

scientific article published on 22 April 2011

A Type II Polyketide Synthase from the Gram-Negative BacteriumStigmatella aurantiaca Is Involved in Aurachin Alkaloid Biosynthesis

article

A brief tour of myxobacterial secondary metabolism.

scientific article

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

scientific article

A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiaca

scientific article published on 04 August 2014

A new recombineering system for Photorhabdus and Xenorhabdus

scientific article published on 24 December 2014

A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria

scientific article published on 25 June 2002

A novel type of geosmin biosynthesis in myxobacteria

scientific article published in June 2005

A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase.

scientific article

A transposon-based strategy to scale up myxothiazol production in myxobacterial cell factories

scientific article published on 13 May 2008

A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin

scientific article

Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum

scholarly article by Frank Surup et al published 5 September 2018 in ACS Chemical Biology

Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria.

scientific article

Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA

scientific article published on 27 November 2018

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus

scientific article published on 10 March 2015

Aetherobacter fasciculatus gen. nov., sp. nov. and Aetherobacter rufus gen. nov., sp. nov., two novel myxobacteria with promising biotechnological applications.

scientific article

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus.

scientific article published on 16 May 2017

Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp.

scientific article published on October 2014

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

scientific article published on 18 September 2020

An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase

scientific article published on 6 December 2012

An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication

scientific article published on 04 November 2020

An unusual thioesterase promotes isochromanone ring formation in ajudazol biosynthesis

scientific article published in May 2010

Analysis of myxobacterial secondary metabolism goes molecular.

scientific article

Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS.

scientific article published in September 2010

Analytics of the therapeutic peptide aviptadil by sheathless CE-MS and comparison with nanoRP-HPLC-MS.

scientific article published on 5 October 2013

Angiolactone, a new Butyrolactone isolated from the terrestrial myxobacterium, Angiococcus sp

scientific article published on 07 May 2014

Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. ⬇️

scientific article published on 3 September 2014

Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2.

scientific article

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.

scientific article published on 19 October 2015

Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins

scientific article

Antimalarial activity of the myxobacterial macrolide chlorotonil a. ⬇️

scientific article

Anti‐angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives ⬇️

scientific article published on November 1, 2012

Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro[4.4]non-8-ene

scientific article published on 15 February 2019

Artificial intelligence for natural product drug discovery ⬇️

scientific article from 2023

AuaA, a membrane-bound farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4-hydroxyquinoline in the biosynthesis of aurachins

scientific article published on 10 June 2011

Author Correction: Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

correction of a scholarly article

Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads

scientific article published on 5 January 2006

Bendigoles D–F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009 ⬇️

scientific article published on May 30, 2011

Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach

scientific article

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures

scientific article

Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation.

scientific article

Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla

scientific article

Biosynthesis and identification of volatiles released by the myxobacterium Stigmatella aurantiaca

scientific article

Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus

scientific article published on June 2007

Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity

scientific article published on 18 March 2011

Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme.

scientific article

Biosynthesis of Iso-Fatty Acids in Myxobacteria: Iso-Even Fatty Acids Are Derived by α-Oxidation from Iso-Odd Fatty Acids

scientific article published on 01 January 2005

Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus ⬇️

scientific article published on 08 July 2020

Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains

scientific article

Biosynthesis of iso-fatty acids in myxobacteria

scientific article published on 27 June 2005

Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

scientific article

Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.

scientific article

Biosynthesis of the Klebsiella oxytoca pathogenicity factor tilivallin: Heterologous expression, in vitro biosynthesis and inhibitor development

scientific article published in February 2018

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699 ⬇️

scientific article published on February 1, 1998

Biosynthesis of the myxobacterial antibiotic corallopyronin A.

scientific article published in June 2010

Biosynthesis of the off-flavor 2-methylisoborneol by the myxobacterium Nannocystis exedens

scientific article published in January 2007

Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity

scientific article published in April 2010

Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus

scientific article

Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity.

scientific article published on 15 June 2015

Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class

scientific article published on 01 November 2021

CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone

scientific article published on 7 September 2017

Chapter 3 Discovering Natural Products from Myxobacteria with Emphasis on Rare Producer Strains in Combination with Improved Analytical Methods

scientific article published on 01 January 2009

Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

scientific article

Characterization of an unusual glycerate esterification process in vioprolide biosynthesis

scientific article published on 22 October 2018

Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.

scientific article

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

scientific article published on 05 December 2019

Chemically Unprecedented Biocatalytic (AuaG) Retro-[2,3]-Wittig Rearrangement: A New Insight into Aurachin B Biosynthesis

scientific article published on 10 September 2014

Class I Methyltransferase VioH Catalyzes Unusual S-Adenosyl-l-methionine Cyclization Leading to 4-Methylazetidinecarboxylic Acid Formation during Vioprolide Biosynthesis

scientific article published on 19 December 2018

Combining in silico and biophysical methods for the development of Pseudomonas aeruginosa quorum sensing inhibitors: an alternative approach for structure-based drug design

scientific article published on 18 October 2013

Comparative genomic analysis of fruiting body formation in Myxococcales

scientific article

Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

scientific article published in 2022

Complete genome sequence of the myxobacterium Sorangium cellulosum

scientific article

Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15.

scientific article

Concepts and Methods to Access Novel Antibiotics from Actinomycetes.

scientific article

Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin

scientific article published on 30 October 2013

Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering.

scientific article published on 4 February 2015

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

scientific article published on 07 December 2020

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria ⬇️

scientific article published on 23 February 2018

Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

scientific article published on 29 July 2016

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

scientific article published on 28 September 2017

Critical variations of conjugational DNA transfer into secondary metabolite multiproducing Sorangium cellulosum strains So ce12 and So ce56: development of a mariner-based transposon mutagenesis system

scientific article published in January 2004

Crocadepsins - Depsipeptides from the Myxobacterium Chondromyces crocatus found by a Genome Mining Approach

scientific article

Crystal Structure of a Molecular Assembly Line

scientific article published on 01 January 2008

Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus

scientific article

Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

scientific article published on 29 July 2016

Cylindrofridins A-C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum stagnale.

scientific article published on 18 December 2015

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

scholarly article by Sascha Baumann et al published 15 December 2014 in Angewandte Chemie International Edition

Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104.

scientific article published on 27 July 2015

Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp. ⬇️

scientific article

Cystomanamides: structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteria

scientific article published on 15 April 2014

Cytotoxic fatty acid amides from Xenorhabdus

scientific article published on 12 July 2011

DKxanthene biosynthesis--understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism

scientific article published in August 2008

Darobactine mit Überlegener Antibiotischer Aktivität Generiert durch Strukturgeleitetes Kryo‐EM‐Biosynthese‐Design**

scientific article published in 2022

Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering**

scientific article published in 2022

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

scientific article published on 5 October 2014

Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56

scientific article published on 01 March 2007

Development of simple media which allow investigations into the global regulation of chivosazol biosynthesis with Sorangium cellulosum So ce56.

scientific article published on January 2006

Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2). ⬇️

scientific article published on 13 October 2015

Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.

scientific article

Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci

scientific article published on 7 October 2014

Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity

scientific article

Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens.

scientific article published on 20 July 2017

Discovery and biological activity of new chondramides from Chondromyces sp.

scientific article published on 19 August 2013

Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004.

scientific article published in March 2010

Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF.

scientific article published in March 2009

Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species. ⬇️

scientific article published on 16 April 2018

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.

scientific article

Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining

scientific article published on 25 January 2012

Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin

scientific article published on 5 January 2017

Don't Classify Polyketide Synthases

scientific article published on 01 January 2004

Draft Genome Sequence and Annotation of the Obligate Bacterial Endosymbiont Caedibacter taeniospiralis, Causative Agent of the Killer Phenotype in Paramecium tetraurelia

scientific article published on 18 January 2018

Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2. ⬇️

scientific article published on 20 January 2016

Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionisation-time-of-flight mass spectrometry and compound-based principal component analysis

scientific article published on 28 June 2008

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition

scientific article published on 13 August 2008

Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers

scientific article published on 01 January 2011

Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti.

scientific article

Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.

scientific article

Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations

scientific article published on 3 December 2013

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

scientific article published on 12 February 2019

Enhancer binding proteins act as hetero-oligomers and link secondary metabolite production to myxococcal development, motility, and predation

scientific article published in November 2012

Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

scientific article published on 01 April 2015

Establishment of a real-time PCR protocol for expression studies of secondary metabolite biosynthetic gene clusters in the G/C-rich myxobacterium Sorangium cellulosum So ce56.

scientific article

Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin

scientific article

Evolutionary implications of bacterial polyketide synthases

scientific article

Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables'.

scientific article

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners ⬇️

scientific article published on 16 August 2021

Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems

scientific article published in 2021

Exploring chemical diversity of α-pyrone antibiotics: molecular basis of myxopyronin biosynthesis

scientific article published on 26 August 2013

Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma

scientific article published on 4 April 2014

Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 Fatty acids.

scientific article

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.

scientific article published on 6 August 2015

Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic.

scientific article

From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes

scientific article published on 11 September 2007

Full Stereochemical Determination of Ajudazols A and B by Bioinformatics Gene Cluster Analysis and Total Synthesis of Ajudazol B by an Asymmetric Ortholithiation Strategy

article

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.

scientific article published in May 2012

Functions of genes and enzymes involved in phenalinolactone biosynthesis

scientific article published in July 2010

Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics

scientific article published on 29 August 2018

Future potential for anti-infectives from bacteria - how to exploit biodiversity and genomic potential

scientific article

GeneTrail--advanced gene set enrichment analysis

scientific article published on 25 May 2007

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis.

scientific article

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.

scientific article published on 15 February 2016

Genome mining in Sorangium cellulosum So ce56: identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450.

scientific article published on 20 August 2009

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria ⬇️

scientific article published on 01 December 2018

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.

scientific article published on 16 April 2018

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria ⬇️

scientific article published on 25 April 2022

Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1.

scientific article published on 13 February 2017

Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029.

scientific article published on 3 May 2017

Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering

scientific article published in February 2008

Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis

scientific article published in March 2012

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering

scientific article published in March 2005

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin

scientific article published on 19 December 2014

Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis

scientific article published on 19 December 2020

Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris.

scientific article

Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.

scientific article published on 21 August 2014

Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus

scientific article

High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium

scientific article published on 17 June 2013

Homospermidine Lipids: A Compound Class Specifically Formed during Fruiting Body Formation of Myxococcus xanthus DK1622.

scientific article published on 29 November 2017

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.

scientific article

Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutum

scientific article published on 21 May 2014

Hyalachelins A–C, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium minutum

scientific article published on 24 July 2014

Hyaladione, an S-Methyl Cyclohexadiene-dione from Hyalangium minutum

scientific article published on 12 April 2012

Identification and Characterization of the Althiomycin Biosynthetic Gene Cluster in Myxococcus xanthus DK897

article

Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56

scientific article

Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.

scientific article published in August 2004

Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteria ⬇️

scientific article published on 21 December 2007

Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1

scientific article published on 10 October 2005

Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.

scientific article

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

scientific article published in 2021

Improved riboflavin production with Ashbya gossypii from vegetable oil based on 13C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR.

scientific article published on 11 April 2018

Improved seamless mutagenesis by recombineering using ccdB for counterselection

scientific article published on 24 December 2013

Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow.

scientific article published on 16 October 2014

In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor.

scientific article published on 19 September 2014

In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

scientific article published on 16 March 2021

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

scientific article published on 6 June 2013

Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea.

scientific article published on 16 February 2016

Indiacens A and B: Prenyl Indoles from the Myxobacterium Sandaracinus amylolyticus

scientific article published on 04 October 2012

Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae

scientific article

Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells.

scientific article

Inhibition of the V-ATPase by Archazolid A - a new strategy to inhibit EMT.

scientific article

Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.

scientific article

Insights into multienzyme docking in hybrid PKS-NRPS megasynthetases revealed by heterologous expression and genetic engineering

scientific article published in May 2010

Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690.

scientific article

Interrogation of Streptomyces avermitilis for efficient production of avermectins.

scientific article published in March 2016

Investigation of cytochromes P450 in myxobacteria: excavation of cytochromes P450 from the genome of Sorangium cellulosum So ce56.

scientific article

Investigations to the Antibacterial Mechanism of Action of Kendomycin

scientific article

Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

scientific article published on 23 December 2011

Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

scientific article published on 24 May 2016

Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin.

scientific article published on 12 July 2016

Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from Myxobacteria

scientific article published on 16 April 2013

Iterative Methylations Resulting in the Biosynthesis of the t-Butyl Group Catalyzed by a B12-Dependent Radical SAM Enzyme in Cystobactamid Biosynthesis.

scientific article published on 19 July 2018

Jahnellamides, α-keto-β-methionine-containing peptides from the terrestrial myxobacterium Jahnella sp.: structure and biosynthesis.

scientific article

Juniperolide A: A New Polyketide Isolated from a Terrestrial Actinomycete, Streptomyces sp

scientific article published on 21 November 2012

Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection

scientific article published on 18 September 2017

Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria.

scientific article published on 9 March 2017

Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. ⬇️

scientific article published on 3 April 2013

Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.

scientific article published on 21 August 2012

MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition

scientific article published on 27 April 2016

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

scientific article

Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes).

scientific article

Markerless mutations in the myxothiazol biosynthetic gene cluster: a delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain.

scientific article published in October 2003

Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases.

scientific article published in October 2003

Metabolic and Biosynthetic Diversity in Marine Myxobacteria

scientific article published on 05 September 2018

Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation

scientific article published on December 2006

Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase

scientific article

Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide

article

Methods to optimize myxobacterial fermentations using off-gas analysis

scientific article published on 9 May 2012

Minicystis rosea gen. nov., sp. nov., a polyunsaturated fatty acid-rich and steroid-producing soil myxobacterium.

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors

scientific article published on 8 March 2011

Moderately thermophilic Myxobacteria: novel potential for the production of natural products isolation and characterization

scientific article

Modular construction of a functional artificial epothilone polyketide pathway

scientific article

Molecular Basis of Elansolid Biosynthesis: Evidence for an Unprecedented Quinone Methide Initiated Intramolecular Diels-Alder Cycloaddition/Macrolactonization

scientific article published on 29 March 2011

Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5.

scientific article published in June 2006

Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria ⬇️

scientific article published on 7 April 2011

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.

scientific article published in November 2007

Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa

scientific article published on 25 September 2012

Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological differentiation

scientific article published on 26 May 2008

Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones.

scientific article published on July 2007

Mutations improving production and secretion of extracellular lipase by Burkholderia glumae PG1.

scientific article published on 17 October 2015

Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites.

scientific article published on 23 April 2009

Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry.

scientific article published on 11 June 2007

Myxobacterial secondary metabolites: bioactivities and modes-of-action.

scientific article published on 03 June 2010

Myxoprincomide: A Natural Product from Myxococcus xanthus Discovered by Comprehensive Analysis of the Secondary Metabolome

article

Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases

scientific article published on August 2006

Nannocystis konarekensis sp. nov., a novel myxobacterium from an Iranian desert

scientific article published on 18 January 2018

Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria

scientific article published on 14 November 2014

Natural products from myxobacteria: novel metabolites and bioactivities.

scientific article published on December 2016

Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity

scientific article published on 01 March 2006

Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome

scientific article published on 02 January 2019

Novel and revisited approaches in antituberculosis drug discovery.

scientific article

Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2.

scientific article

Novel insights into siderophore formation in myxobacteria

scientific article

NtcA: a negative regulator of secondary metabolite biosynthesis in Sorangium cellulosum

scientific article published on 12 November 2008

Octapeptins: Lipopeptide Antibiotics against Multidrug-Resistant Superbugs.

scientific article published in April 2018

Oleaceran: A Novel Spiro[isobenzofuran-1,2′-naptho[1,8-bc]furan] Isolated from a Terrestrial Streptomyces sp

scientific article published on 26 June 2013

Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp ⬇️

scientific article published on 22 January 2014

On the Biosynthetic Origin of Methoxymalonyl-Acyl Carrier Protein, the Substrate for Incorporation of “Glycolate” Units into Ansamitocin and Soraphen A

scientific article published on 01 November 2006

Optimization of the biotechnological production of a novel class of anti-MRSA antibiotics from Chitinophaga sancti

scientific article published on 17 August 2017

Overproduction of Magnetosomes by Genomic Amplification of Biosynthesis-Related Gene Clusters in a Magnetotactic Bacterium.

scientific article published on 11 March 2016

Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164.

scientific article published on 20 December 2017

Paenilarvins: Iturin family lipopeptides from the honey bee pathogen Paenibacillus larvae ⬇️

scientific article

Persicamidine – Außergewöhnliche Sesquarterpenoide mit potenter antiviraler Bioaktivität gegen Coronaviren

scientific article published in 2023

Phaselicystis flava gen. nov., sp. nov., an arachidonic acid-containing soil myxobacterium, and the description of Phaselicystidaceae fam. nov.

scientific article

Pinensins: the first antifungal lantibiotics

scientific article published on 24 July 2015

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

scientific article published on 06 September 2019

Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase.

scientific article published on 6 January 2005

Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae

scientific article published on 8 November 2013

Precursor-directed syntheses and biological evaluation of new elansolid derivatives

scientific article

Predicting the Presence of Uncommon Elements in Unknown Biomolecules from Isotope Patterns.

scientific article published on 11 July 2016

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.

scientific article published on 21 January 2016

Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis

scientific article

Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy

scientific article

Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host

scientific article published on 01 November 2019

Production of extracellular heterologous proteins in Streptomyces rimosus, producer of the antibiotic oxytetracycline. ⬇️

scientific article published on 7 February 2018

Production of the Antifungal Isochromanone Ajudazols A and B inChondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

scientific article published on 01 January 2008

Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships.

scientific article published on 30 October 2015

Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.

scientific article published in July 2005

Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic

scientific article published on 21 July 2019

Protein-protein interactions in multienzyme megasynthetases.

scientific article

Proteome Analysis ofMyxococcusxanthusby Off-Line Two-Dimensional Chromatographic Separation Using Monolithic Poly-(styrene-divinylbenzene) Columns Combined with Ion-Trap Tandem Mass Spectrometry

scientific article published on 01 October 2006

Proteome analysis of Sorangium cellulosum employing 2D-HPLC-MS/MS and improved database searching strategies for CID and ETD fragment spectra

scientific article published in September 2009

Pyrronazols, Metabolites from the Myxobacteria Nannocystis pusilla and N. exedens, Are Unusual Chlorinated Pyrone-Oxazole-Pyrroles

scientific article published on 24 January 2014

Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites.

scientific article published on 7 June 2017

Racemicystis crocea gen. nov., sp. nov., a soil myxobacterium in the family Polyangiaceae.

scientific article

Racemicystis persica sp. nov., a myxobacterium from soil.

scientific article

Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.

scientific article published on 2 March 2015

Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria ⬇️

scientific article published on 23 July 2021

RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression

scientific article published on 2 June 2016

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways ⬇️

scientific article published on 05 July 2013

Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways.

scientific article

Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus

scientific article

Revealing the macromolecular targets of complex natural products

scientific article published on 2 November 2014

Reversible Sugar Transfer by Glycosyltransferases as a Tool for Natural Product (Bio)synthesis

scientific article published on 01 January 2007

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota).

scientific article published on 18 August 2015

Roimatacene: An Antibiotic against Gram-Negative Bacteria Isolated from Cystobacter ferrugineus Cb G35 (Myxobacteria)

26 May 2011 article in Chemistry: A European Journal

Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency.

scientific article

Sandaracinus amylolyticus gen. nov., sp. nov., a starch-degrading soil myxobacterium, and description of Sandaracinaceae fam. nov.

scientific article

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products.

scientific article published on 25 April 2014

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria. ⬇️

scientific article

Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria

scientific article published on 17 May 2021

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

scientific article (publication date: 9 August 2016)

Simplified pretubulysin derivatives and their biological effects on cancer cells

scientific article published on 17 January 2014

Simulating the effects of droplet size, high-pressure biodegradation, and variable flow rate on the subsea evolution of deep plumes from the Macondo blowout

scholarly article by David Lindo-Atichati published in July 2016

Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis

scientific article

SorF: A Glycosyltransferase With Promiscuous Donor Substrate Specificity in vitro

scientific article published on 01 May 2007

Soraphen A: A Probe for Investigating the Role of de Novo Lipogenesis during Viral Infection

scientific article published on 16 February 2015

Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity

scientific article published on 9 June 2015

Spiroketal polyketide formation in Sorangium: identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes

scientific article published in February 2007

Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the MyxobacteriumSorangium cellulosum

scientific article published on 01 January 2008

Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum.

scientific article

Stereoselective Synthesis of Deuterium-Labeled (2S)-Cyclohexenyl Alanines, Biosynthetic Intermediates of Cinnabaramide

scientific article published on 19 November 2012

Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies.

scientific article

Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis

scientific article

Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus

scientific article published on 23 May 2017

Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP

scientific article

Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases

scientific article

Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis

scientific article

Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D

scientific article published on 11 November 2021

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking

scientific article

Structure-function analysis for the hydroxylation of Δ4 C21-steroids by the myxobacterial CYP260B1

scientific article

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

scientific article published on 09 January 2020

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

scientific article published on 12 December 2007

Sulfangolids, Macrolide Sulfate Esters from Sorangium cellulosum

scientific article published on 04 April 2012

Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria

scientific article published on 10 November 2020

Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease

scientific article

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues ⬇️

scientific article published on July 31, 2013

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum

scientific article published on 06 June 2019

Synthetic Biotechnology to Study and Engineer Ribosomal Bottromycin Biosynthesis ⬇️

scientific article published on September 27, 2012

Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production

scientific article published on 08 August 2018

Synthetic biology approaches to establish a heterologous production system for coronatines.

scientific article

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum

scientific article

Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

scientific article published on 03 April 2019

The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

scientific article published on 9 December 2016

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC.

scientific article

The CYPome of Sorangium cellulosum So ce56 and Identification of CYP109D1 as a New Fatty Acid Hydroxylase

scientific article published on 01 December 2010

The Mechanism of Action of Lysobactin

scientific article published on 18 December 2015

The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis

scientific article

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

scientific article

The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility

scientific article (publication date: 2014)

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase

scientific article published on 16 November 2020

The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target

scientific article published on 11 July 2016

The biosynthesis of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium Chitinophaga Fx7914.

scientific article published on September 2010

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

scientific article published on 23 January 2002

The impact of bacterial genomics on natural product research.

scientific article

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles

scientific article

The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum

scientific article published in September 2003

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.

scientific article

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

scientific article published in May 2023

The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli ⬇️

scientific article published on October 23, 1998

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.

scientific article published on 21 September 2016

The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation ⬇️

scholarly article

The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen

scientific article published in PLoS ONE

Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products ⬇️

scientific article published on 5 October 2017

Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System

scientific article published on 24 August 2017

Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2.

scientific article published on 21 July 2017

Total Synthesis of Crocagin A.

scientific article published on 15 August 2017

Total and Semi-Syntheses of Antimicrobial Thuggacin Derivatives

scientific article published on 04 February 2015

Total syntheses and biological evaluation of miuraenamides

scientific article

Total synthesis and antibacterial activity of dysidavarone A.

scientific article published on 7 February 2013

Towards the sustainable discovery and development of new antibiotics

scientific article published in 2021

Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

scientific article published on 25 April 2016

Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides

scientific article published on 04 June 2019

Two Functionally Redundant Sfp‐Type 4′‐Phosphopantetheinyl Transferases Differentially Activate Biosynthetic Pathways inMyxococcus xanthus

scientific article published on 01 July 2008

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

scientific article

Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin

scientific article published on 8 September 2015

Unprecedented Anthranilate Priming Involving Two Enzymes of the Acyl Adenylating Superfamily in Aurachin Biosynthesis

scientific article published on 22 July 2011

Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum

scientific article

Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens.

scientific article published on January 2009

V-ATPase inhibition overcomes trastuzumab resistance in breast cancer

scientific article published on 5 September 2013

V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells.

scientific article published on 30 January 2014

Vitiosangium cumulatum gen. nov., sp. nov. and Vitiosangium subalbum sp. nov., soil myxobacteria, and emended descriptions of the genera Archangium and Angiococcus, and of the family Cystobacteraceae

scientific article

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

scientific article published on 6 May 2015

p-Hydroxyacetophenone Amides from Cystobacter ferrugineus, strain Cb G35

scientific article published on 19 May 2011

Paulina is supported by:

About Paulina

Help