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List of works by Steven Mennerick

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

scientific article

24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation

scientific article

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

scientific article

A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation

scientific article published on 02 January 2014

A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing

scientific article published on May 2008

A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons

scientific article published on 20 September 2006

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors

scientific article

Action potential fidelity during normal and epileptiform activity in paired soma-axon recordings from rat hippocampus

scientific article published on 12 May 2005

Action potential initiation and propagation in CA3 pyramidal axons

scientific article published on 21 February 2007

Action potential initiation and propagation: upstream influences on neurotransmission

scientific article published on 19 March 2008

Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current

scientific article published in August 2003

Acute and chronic effects of ethanol on learning-related synaptic plasticity.

scientific article published on 16 December 2013

Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment

scientific article

Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation

scientific article published on 4 April 2018

An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.

scientific article

Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol

scientific article

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

scientific article published on 25 February 2007

Astrocyte membrane responses and potassium accumulation during neuronal activity.

scientific article published in January 2007

Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro

scientific article

Astrocytes exert a pro-apoptotic effect on neurons in postnatal hippocampal cultures

scientific article published on January 2005

Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons

scientific article published on April 2010

Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes.

scientific article

Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.

scientific article published in March 2005

Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

scientific article

Chemogenetic Isolation Reveals Synaptic Contribution of δ GABA Receptors in Mouse Dentate Granule Neurons

scientific article published on 03 August 2018

Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons

scientific article

Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA.

scientific article published on 29 March 2017

Cross talk between synaptic receptors mediates NMDA-induced suppression of inhibition.

scientific article

Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

scientific article

Detection of submillisecond spike timing differences based on delay-line anticoincidence detection.

scientific article published on 21 August 2013

Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

scientific article

Differential Presynaptic ATP Supply for Basal and High-Demand Transmission.

scientific article published on 16 January 2017

Differential effects of axon initial segment and somatodendritic GABAA receptors on excitability measures in rat dentate granule neurons.

scientific article

Differential requirement for protein synthesis in presynaptic unmuting and muting in hippocampal glutamate terminals

scientific article

Don't curse the darkness, light a candle: fluorescence studies of axon excitability

scientific article published on 01 September 2011

Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses

scientific article

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors

scientific article published on 13 March 2008

Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures

scientific article published in June 1998

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

scientific article published on April 2008

Ethanol-induced death of postnatal hippocampal neurons

scientific article published in August 2002

Excitotoxicity triggered by Neurobasal culture medium

scientific article

Fast phasic release properties of dopamine studied with a channel biosensor

scientific article

Feeding hungry neurons: astrocytes deliver food for thought

scientific article

GIRK channel modulation by assembly with allosterically regulated RGS proteins ⬇️

scientific article published on November 19, 2012

Glial contributions to excitatory neurotransmission in cultured hippocampal cells

scientific article

High threshold, proximal initiation, and slow conduction velocity of action potentials in dentate granule neuron mossy fibers

scientific article published on 14 May 2008

Hydrophobic anions potently and uncompetitively antagonize GABAA receptor function in the absence of a conventional binding site ⬇️

scientific article published on September 1, 2011

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

scientific article published in August 2003

Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine

scientific article published on 07 October 2013

Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.

scientific article

Ketamine: NMDA Receptors and Beyond.

scientific article

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

scientific article

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers

scholarly article

Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro

scientific article published in August 2015

Magnesium induces neuronal apoptosis by suppressing excitability.

scientific article

Mechanisms of neurosteroid interactions with GABA(A) receptors.

scientific article

Mild chronic perturbation of inhibition severely alters hippocampal function

scientific article published on 11 November 2019

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

scientific article published on 29 April 2009

Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia

scientific article published on 30 October 2003

Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function

scientific article published in February 2002

Neurosteroid access to the GABAA receptor

scientific article

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published in April 2005

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes

scientific article published in July 2006

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens

scientific article published on 12 March 2007

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes

scientific article published on 15 February 2008

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

scientific article published on 15 September 2010

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity

scientific article published on 6 May 2011

Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors

scientific article published on 18 January 2012

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

scientific article

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published on December 2003

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation

scientific article published on 30 August 2007

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

scientific article published on 27 September 2019

Neurosteroids as therapeutic leads in psychiatry

scientific article

Neurosteroids, stress and depression: potential therapeutic opportunities.

scientific article published on 17 October 2012

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids

scientific article

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

scientific article published on 4 November 2011

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin ⬇️

scientific article published on April 1, 1998

Noncompetitive, voltage-dependent NMDA receptor antagonism by hydrophobic anions

scientific article published on 9 November 2012

Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, alpha 3 beta 4, expressed in transfected eucaryotic cells.

scientific article

Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.

scientific article published on 20 February 2014

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

scientific article

Physiological activity depresses synaptic function through an effect on vesicle priming.

scientific article published in June 2006

Plastic elimination of functional glutamate release sites by depolarization.

scientific article

Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis.

scientific article published on 23 February 2018

Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors

scientific article published in February 1999

Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults ⬇️

scientific article published on May 14, 2011

Presynaptically silent synapses studied with light microscopy

scientific article

Presynaptically silent synapses: dormancy and awakening of presynaptic vesicle release.

scientific article published on 09 September 2011

Rapid activation of dormant presynaptic terminals by phorbol esters

scientific article published on July 2010

Rapid calcium-current kinetics in synaptic terminals of goldfish retinal bipolar neurons

scientific article published on 01 November 1998

Recent developments in structure–activity relationships for steroid modulators of GABAA receptors

article

Redox modulation of T-type calcium channels in rat peripheral nociceptors

scientific article

Reluctant Vesicles Coaxed into the Limelight

scientific article published on 01 May 2005

Reluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neurons.

scientific article published in April 2005

Selective effects of potassium elevations on glutamate signaling and action potential conduction in hippocampus.

scientific article

Slow actions of neuroactive steroids at GABAA receptors.

scientific article

Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.

scientific article

Swelling of Müller cells induced by AP3 and glutamate transport substrates in rat retina

scientific article published on 01 August 1996

Synaptic NMDA receptors mediate hypoxic excitotoxic death

scientific article

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo

scientific article published in December 2005

Temporal ordering of pathogenic events following transient global ischemia

scientific article published in April 1998

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

scientific article (publication date: 30 October 2013)

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

scientific article published on December 2009

The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors

scientific article

The sticky issue of neurosteroids and GABA(A) receptors

scientific article

Ultrafast Exocytosis Elicited by Calcium Current in Synaptic Terminals of Retinal Bipolar Neurons

scientific article published on 01 December 1996

Vesicle Pool Heterogeneity at Hippocampal Glutamate and GABA Synapses

scientific article published on 01 September 2007

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

scholarly article by Mariangela Chisari et al published January 2019 in Neuropharmacology

[43] Measurement of glial transport currents in microcultures: Application to excitatory neurotransmission

article

γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type.

scientific article

δ subunit-containing GABAA IPSCs are driven by both synaptic and diffusional GABA in mouse dentate granule neurons

scientific article published on 27 February 2020

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