List of works - Sandra B. Gabelli

A Nudix Hydrolase Necessary for Mycobacterium Tuberculosis Survival under Oxidative Stress

scholarly article by Kerstin A. Wolff et al published January 2015 in Biophysical Journal

A Tunable Brake for HECT Ubiquitin Ligases

scientific article published in May 2017

A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis

scientific article

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

scientific article

A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development

scientific article published on 17 April 2015

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

scientific article published on 14 December 2020

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

scientific article published in March 2022

Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

scientific article

Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag

scientific article published on 15 April 2015

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

scientific article published on 02 August 2018

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

scientific article published on 05 November 2019

Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

scientific article published on 12 March 2018

Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

scientific article

Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs

scientific article published on 03 June 2020

C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors

scientific article published on 24 August 2005

Ca-dependent regulation of sodium channels Na1.4 and Na1.5 is controlled by the post-IQ motif

scientific article published on 03 April 2019

Calmodulin and Ca(2+) control of voltage gated Na(+) channels

scientific article published on 28 July 2015

Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase

scientific article published on 28 October 2010

Cardiac Sodium Channel: Activation by CaM Involves a NaV1.5-NaV1.5 Interaction

Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263].

scientific article published on 8 August 2017

Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

scientific article

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

scientific article

Diacylglycerol kinases: Relationship to other lipid kinases

scientific article published on 28 September 2018

Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

Explanatory chapter: troubleshooting protein expression: what to do when the protein is not soluble.

scientific article published in January 2014

Explanatory chapter: troubleshooting recombinant protein expression: general

scientific article published in January 2014

Gel filtration chromatography (size exclusion chromatography) of proteins

scientific article published in January 2014

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

scientific article published on 27 July 2015

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II

scientific article published on 30 January 2019

Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase

scientific article published on 17 October 2008

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

scientific article

Intracellular production of hydrogels and synthetic RNA granules by multivalent enhancers

Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions.

scientific article published on 6 November 2017

Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis

scientific article

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

scientific article

Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase

scientific article

Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL pro

scientific article

Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction

scientific article published in June 2005

NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

scientific article

Nudix hydrolases degrade protein-conjugated ADP-ribose

scientific article published on 16 December 2015

Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

scientific article

Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.

scientific article

PI3Kα Inhibitors That Inhibit Metastasis ⬇️

scientific article published on September 1, 2010

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes

scientific article published on 11 May 2017

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

scientific article published on 09 July 2013

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

scientific article

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

scientific article

Rapid PD-L1 detection in tumors with PET using a highly specific peptide

scientific article published on 23 December 2016

Regulation of the NaV1.5 cytoplasmic domain by calmodulin

scientific article

Salting out of proteins using ammonium sulfate precipitation

scientific article

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design

scientific article

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

scientific article published on 26 February 2019

Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid

scientific article

Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

scientific article published on 11 April 2019

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus

scientific article published on 2 November 2015

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

scientific article

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

scientific article

Structural comparisons of class I phosphoinositide 3-kinases

scientific article published on September 2008

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

scientific article published on 06 September 2021

Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition

scientific article

Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus

scientific article

Structure and activity of the axon guidance protein MICAL

scientific journal article

Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis

scientific article

Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus

scientific article

Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis

scientific article

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

scientific article

Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

scientific article

Structure of the RECK CC domain, an evolutionary anomaly

scientific article published on 15 June 2020

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

scientific article (publication date: 13 February 2003)

Structures and mechanisms of Nudix hydrolases.

scientific article

TCR β chain-directed bispecific antibodies for the treatment of T cell cancers

scientific article published on 01 March 2021

The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

scientific article

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

scientific article

Using ion exchange chromatography to purify a recombinantly expressed protein

scientific article

X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction

scientific article

List of works by Sandra B. Gabelli

A Nudix Hydrolase Necessary for Mycobacterium Tuberculosis Survival under Oxidative Stress

A Tunable Brake for HECT Ubiquitin Ligases

A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs

C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors

Ca-dependent regulation of sodium channels Na1.4 and Na1.5 is controlled by the post-IQ motif

Calmodulin and Ca(2+) control of voltage gated Na(+) channels

Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase

Cardiac Sodium Channel: Activation by CaM Involves a NaV1.5-NaV1.5 Interaction

Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263].

Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

Diacylglycerol kinases: Relationship to other lipid kinases

Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

Explanatory chapter: troubleshooting protein expression: what to do when the protein is not soluble.

Explanatory chapter: troubleshooting recombinant protein expression: general

Gel filtration chromatography (size exclusion chromatography) of proteins

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II

Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

Intracellular production of hydrogels and synthetic RNA granules by multivalent enhancers

Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions.

Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase

Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL pro

Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction

NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

Nudix hydrolases degrade protein-conjugated ADP-ribose

Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.

PI3Kα Inhibitors That Inhibit Metastasis ⬇️

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

Rapid PD-L1 detection in tumors with PET using a highly specific peptide

Regulation of the NaV1.5 cytoplasmic domain by calmodulin

Salting out of proteins using ammonium sulfate precipitation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid

Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Structural comparisons of class I phosphoinositide 3-kinases

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition

Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus

Structure and activity of the axon guidance protein MICAL

Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis

Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus

Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

Structure of the RECK CC domain, an evolutionary anomaly

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

Structures and mechanisms of Nudix hydrolases.

TCR β chain-directed bispecific antibodies for the treatment of T cell cancers

The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Using ion exchange chromatography to purify a recombinantly expressed protein

X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction