List of works by Patrick G. Kehoe

A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort.

scientific article published on 15 June 2016

A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity

scientific article published on 14 September 2004

A full genome scan for late onset Alzheimer's disease.

scientific article published in February 1999

A multi-center study of ACE and the risk of late-onset Alzheimer's disease

scientific article published on January 2011

A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol

scientific article published on 18 July 2016

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

scientific article published on 25 January 2020

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

scientific article published in May 2000

Abeta-degrading enzymes in Alzheimer's disease.

scientific article published on April 2008

Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activities.

scientific article published in January 2011

Activators and inhibitors of the plasminogen system in Alzheimer's disease.

scientific article published on April 2012

Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

scientific article published in January 2014

Alpha-2 macroglobulin gene and Alzheimer disease.

scientific article published in May 1999

Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease.

scientific article published on 10 January 2008

Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia

scientific article published on 15 March 2016

Aluminum in the Diet and Alzheimer's Disease: From Current Epidemiology to Possible Disease-Modifying Treatment

scholarly article by Vincenza Frisardi et al published 24 March 2010 in Journal of Alzheimer's Disease

Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment

scientific article published on January 2010

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

scientific article published on 30 November 2015

Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe

scientific article

Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease.

scientific article published on 5 February 2011

Angiotensin receptor blockers associated with decreased incidence and progression of dementia in older men with cardiovascular disease

scientific article published on 01 August 2010

Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology

scientific article published on 3 April 2017

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

scientific article

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

scientific article published on 31 October 2007

Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology

scientific article

Angiotensin-converting enzyme in cerebrospinal fluid and risk of brain atrophy

scientific article published in January 2015

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

scientific article published on 28 December 2011

Antioxidant and anti-inflammatory effects of Scoparia dulcis L.

scientific article published on 26 August 2011

Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia.

scientific article published on 11 November 2010

Association of combination statin and antihypertensive therapy with reduced Alzheimer's disease and related dementia risk

scientific article published on 04 March 2020

Associations of Angiotensin Targeting Antihypertensive Drugs with Mortality and Hospitalization in Primary Care Patients with Dementia

scientific article published on 01 January 2013

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

scientific article published in January 2011

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

scientific article

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

scientific article

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

scientific article published on 23 January 2020

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging ⬇️

scientific article

Blood type gene locus has no influence on ACE association with Alzheimer's disease

scientific article published on 22 January 2015

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

scientific article

CSF biomarker utilisation and ethical considerations of biomarker assisted diagnosis and research in dementia: perspectives from within the European Alzheimer's Disease Consortium (EADC).

scientific article

CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology

scientific article published on 14 September 2019

Can commonly prescribed drugs be repurposed for the prevention or treatment of Alzheimer's and other neurodegenerative diseases? Protocol for an observational cohort study in the UK Clinical Practice Research Datalink.

scientific article

Case-control study of presenelin-1 intronic polymorphism

scientific article published in June 1999

Caveolin-1 and -2 and their relationship to cerebral amyloid angiopathy in Alzheimer's disease

scientific article

Cerebral Aβ40 and systemic hypertension.

scientific article

Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer's Disease

scientific article published on 01 January 2019

Challenges to and Facilitators of Recruitment to an Alzheimer's Disease Clinical Trial: A Qualitative Interview Study

scientific article published on 01 January 2019

Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme

scientific article

Clearance of Abeta from the brain in Alzheimer's disease. Foreword.

scientific article published in April 2008

Clusterin mRNA and protein in Alzheimer's disease

scientific article published in January 2012

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

scientific article published on 7 June 2021

Common variants of ACE contribute to variable age-at-onset of Alzheimer’s disease

scientific article published on 17 February 2004

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

scientific article

Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations.

scientific article

Correction to: ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

scientific article published on 27 September 2020

Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease

scientific article

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

scientific article published in June 2015

Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy

scientific article published in October 2006

Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.

scientific article published in May 2017

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue

scientific article published on 28 March 2014

Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages.

scientific article published on 25 September 2006

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.

scientific article published in October 2012

Distribution and Expression of Picalm in Alzheimer Disease ⬇️

scientific article published on October 1, 2010

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

scientific article

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease

scientific article published on 24 April 2019

Drug repositioning for Alzheimer's disease.

scientific article

Editorial: EADC (European Alzheimer Disease Consortium) recommendations for future Alzheimer disease research in Europe.

scientific article

Effect of botulinum toxin type A, motor imagery and motor observation on motor function of hemiparetic upper limb after stroke.

scientific article

Effects of Hypertension and Anti-Hypertensive Treatment on Amyloid-β (Aβ) Plaque Load and Aβ-Synthesizing and Aβ-Degrading Enzymes in Frontal Cortex

scientific article published on 19 January 2016

Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer's disease.

scientific article

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease

scientific article published on 21 January 2020

Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.

scientific article

Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia

scientific article published on 22 March 2010

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

scientific article published on 18 June 2009

Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression

scientific article

Erratum: Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue

scientific article published on 28 December 2015

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scholarly article published in Nature Genetics

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

article

Ethical aspects of research into Alzheimer disease. A European Delphi Study focused on genetic and non-genetic research.

scientific article published in February 2009

Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology

scientific article published on 26 October 2018

Evidence that the gene encoding insulin degrading enzyme influences human lifespan

scientific article

Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease.

scientific article published in February 2000

Full genome screen for Alzheimer disease: Stage II analysis

article

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic studies on chromosome 12 in late-onset Alzheimer disease.

scientific article published in August 1998

Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.

scientific article published in July 1999

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

scientific article published in April 2004

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.

scientific article

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Haplotypes extending across ACE are associated with Alzheimer's disease

scientific article published in April 2003

Higher soluble amyloid beta concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease

scientific article

Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates

scientific article published on 17 December 2007

Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid

scientific article published on 25 August 2007

Influence of LRP-1 and apolipoprotein E on amyloid-β uptake and toxicity to cerebrovascular smooth muscle cells.

scientific article published in January 2013

Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.

scientific article published on 8 November 2011

Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis Project

scientific article published on 23 February 2012

Interactions between oestrogen and the renin angiotensin system - potential mechanisms for gender differences in Alzheimer's disease.

scientific article published on 18 November 2012

Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

scholarly article by Sophie Laurent et al published 2012 in RSC Advances

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia

scientific article published in June 2015

Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis

scientific article published on 11 December 2019

Is Extracorporeal Shockwave Therapy Combined With Isokinetic Exercise More Effective Than Extracorporeal Shockwave Therapy Alone for Subacromial Impingement Syndrome? A Randomized Clinical Trial.

scientific article published on 31 July 2016

Is amyloid-β an innocent bystander and marker in Alzheimer's disease? Is the liability of multivalent cation homeostasis and its influence on amyloid-β function the real mechanism?

scientific article published in January 2014

Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia

scientific article published on 21 September 2010

LRP-1 variation is not associated with risk of Alzheimer's disease.

scientific article published on 20 February 2010

LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status

scientific article published in September 2012

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

scientific article (publication date: 15 August 2005)

MMP-2, -3 and -9 levels and activity are not related to Abeta load in the frontal cortex in Alzheimer's disease.

scientific article published on 29 October 2007

Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease

scientific article

Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease

scientific article published on 14 September 2006

Neprilysin Protects against Cerebral Amyloid Angiopathy and Aβ-Induced Degeneration of Cerebrovascular Smooth Muscle Cells

scientific article published on 03 April 2011

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity

scientific article published in August 2009

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.

scientific article published in March 1999

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.

scientific article published on 2 August 2011

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy

scientific article published on 16 July 2009

Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-β.

scientific article published in January 2010

Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia

scientific article published on 10 March 2014

Plasminogen and plasmin in Alzheimer's disease.

scientific article

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.

scientific article published on 31 July 2006

Presenilin-1 polymorphism and Alzheimer's disease. The UK Alzheimer's Disease Collaborative Group.

scientific article published in April 1996

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage

scientific article

Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

scientific article published on 19 October 2017

Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease

scientific article

Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's disease and dementia with Lewy bodies.

scientific article published in January 2015

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

scientific article

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial

scientific article published on 12 December 2017

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity

scientific article published in January 2015

Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects.

scientific article published on 22 September 2011

Renin Angiotensin aldosterone system inhibition in controlling dementia-related cognitive decline.

scientific article published on January 2014

Renin-angiotensin system inhibitors and risk of fractures: a prospective cohort study and meta-analysis of published observational cohort studies.

scientific article published on 27 July 2017

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

scientific article published on 23 August 2009

Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline

scientific article

Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study

scientific article published on 23 July 2019

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain

scientific article published in June 2005

Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer's disease risk

scientific article published on August 2003

Single-domain amnestic mild cognitive impairment identified by cluster analysis predicts Alzheimer's disease in the european prospective DESCRIPA study

scientific article published on 3 May 2013

Susceptibility locus for Alzheimer's disease on chromosome 10.

scientific article

TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease

scientific article published on 11 December 2007

The Coming of Age of the Angiotensin Hypothesis in Alzheimer's Disease: Progress Toward Disease Prevention and Treatment?

scientific article published in January 2018

The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk

scientific article published on 01 January 2019

The Rationale and Design of the Reducing Pathology in Alzheimer's Disease through Angiotensin TaRgeting (RADAR) Trial.

scientific article published on 6 December 2017

The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.

scientific article published on 30 May 2012

The Vascular Impairment of Cognition Classification Consensus Study

scientific article published on 10 December 2016

The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study

scientific article published in January 2013

The association of angiotensin-converting enzyme with biomarkers for Alzheimer's disease

scientific article

The association of multiple anti-hypertensive medication classes with Alzheimer's disease incidence across sex, race, and ethnicity

scientific article published in PLoS ONE

The branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase--implications in Alzheimer's disease

scientific article

The cardiovascular and respiratory health of people with schizophrenia

scientific article published on April 2006

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

scientific article

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article

The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project

scientific article published on 05 June 2013

The use of biomarkers for the etiologic diagnosis of MCI in Europe: an EADC survey

scientific article published on 20 August 2014

Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier

scientific article

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

scientific article

Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease

scientific article published in October 2003

Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro

scientific article

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

scientific article published on 09 March 2020

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease ⬇️

scientific article

Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey

scientific article published on 22 August 2019

Using Alzgene-like approaches to investigate susceptibility genes for vascular cognitive impairment

scientific article published on January 2013

VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.

scientific article published on 06 July 2013

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

article

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

scientific article published on 2 September 2016

Vascular genetic factors and human longevity

scientific article published on March 2004

What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England: a trend analysis in the Clinical Practice Research Datalink

scholarly article published 8 September 2017

What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England: a trend analysis in the Clinical Practice Research Datalink

scholarly article published 8 September 2017

What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink.

scientific article

Zibotentan, an Endothelin A Receptor Antagonist, Prevents Amyloid-β-Induced Hypertension and Maintains Cerebral Perfusion

scientific article published on 01 January 2020

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