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List of works by Adrian Whitehouse

A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures

scientific article

A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides

scientific article

A gamma-2 herpesvirus nucleocytoplasmic shuttle protein interacts with importin alpha 1 and alpha 5.

scientific article

A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy

scientific article published in July 2000

A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells ⬇️

scientific article

ARID3B: a Novel Regulator of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle. ⬇️

scientific article published on 10 August 2016

An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.

scientific article

Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri

scientific article

Analysis of the mismatch and insertion/deletion binding properties of Thermus thermophilus, HB8, MutS.

scientific article published on April 1997

Assessment of Herpesvirus saimiri as a potential human gene therapy vector

scientific article published on March 1999

Assessment of infectivity using a Herpesvirus saimiri (HVS) recombinant that expresses HVS-GFP.

scientific article

Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness ⬇️

scientific article published on 06 September 2018

Cellular uptake of highly-functionalized ruthenium(II) tris-bipyridine protein-surface mimetics

scientific article published on 8 December 2011

Characterization of the herpesvirus saimiri ORF73 gene product

scientific article

Characterization of the human beta-catenin gene

scientific article published in February 1996

Contribution of the KSHV and EBV lytic cycles to tumourigenesis ⬇️

scientific article

Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation

scientific article published on 30 June 2021

DNA mismatch repair genes and their association with colorectal cancer (Review).

scientific article published in February 1998

Development of herpesvirus-based episomally maintained gene delivery vectors

scientific article published on April 2004

Distinct transcriptional and functional properties of the R transactivator gene orf50 of the transforming herpesvirus saimiri strain C488.

scientific article

Dysregulation of the miR-30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication

scientific article published on 03 March 2022

Efficient infection and persistence of a herpesvirus saimiri-based gene delivery vector into human tumor xenografts and multicellular spheroid cultures

scientific article

Gardella Gel Analysis to Detect Herpesvirus Saimiri Episomal DNA ⬇️

scientific article published on December 1, 2011

Generation and precise modification of a herpesvirus saimiri bacterial artificial chromosome demonstrates that the terminal repeats are required for both virus production and episomal persistence

scientific article published on December 2003

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology ⬇️

scientific article published on 14 November 2017

Herpesvirus saimiri ORF57: a post-transcriptional regulatory protein

scientific article published on January 2008

Herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein MeCP2.

scientific article published on 31 January 2007

Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line

scientific article published on April 2001

Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration

scientific article published on 2 December 2010

Herpesvirus saimiri-based gene delivery vectors

scientific article

Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro.

scientific article published in March 2000

Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging

scientific article

Herpesvirus saimiri-mediated delivery of the adenomatous polyposis coli tumour suppressor gene reduces proliferation of colorectal cancer cells

scientific article

Herpesvirus saimiri: a potential gene delivery vector (review).

scientific article

Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments ⬇️

scientific article

Identification of a cis-acting element within the herpesvirus saimiri ORF 6 promoter that is responsive to the HVS.R transactivator

scientific article published on June 1997

Identification of a response element in a herpesvirus saimiri mRNA recognized by the ORF57 protein

scientific article published in March 2009

In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector

scientific article

Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. ⬇️

scientific article published on 16 May 2016

Investigating the structural changes due to adenosine methylation of the Kaposi’s sarcoma-associated herpes virus ORF50 transcript

scientific article published on 26 May 2022

Kaposi's sarcoma-associated herpesvirus (KSHV) Rta and cellular HMGB1 proteins synergistically transactivate the KSHV ORF50 promoter

scientific article

Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs

scientific article

Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing. ⬇️

scientific article published on 26 July 2013

Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway

scientific article published on 15 April 2009

Long non-coding RNAs drive metastatic progression in melanoma (Review).

scientific article published on October 2014

Mapping the minimal domain of hMSH-2 sufficient for binding mismatched oligonucleotides

scientific article published on March 1997

Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation ⬇️

scientific article published in November 2017

Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion

scientific article published on 15 July 2020

Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration ⬇️

scientific article published on 15 October 2014

Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signaling

scientific article published on 9 October 2013

Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus ⬇️

scientific article

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

scientific article published on 18 June 2020

Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization

scientific article

Mutation of herpesvirus Saimiri ORF51 glycoprotein specifically targets infectivity to hepatocellular carcinoma cell lines

scientific article published on 9 December 2010

Mutational analysis of the nucleotide binding domain of the mismatch repair enzyme hMSH-2.

scientific article published in December 1996

NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target ⬇️

scientific article (publication date: March 2015)

Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin

scientific article published on 10 June 2011

Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs

scientific article published on 20 October 2009

Nucleolar proteomics and viral infection

scientific article

Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA.

scholarly article

ORF57: Master regulator of KSHV mRNA biogenesis

scientific article published on 10 July 2010

Open reading frame 73 is required for herpesvirus saimiri A11-S4 episomal persistence

scientific article published in October 2005

Potential of herpesvirus saimiri-based vectors to reprogram a somatic Ewing's sarcoma family tumor cell line

scientific article published on 17 April 2013

Production of Recombinant Herpesvirus Saimiri-Based Vectors: Figure 1 ⬇️

scientific article published on December 1, 2011

Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system

scientific article

Progress and prospects: human artificial chromosomes

scientific article published on 27 August 2009

Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication ⬇️

scientific article

Reduction in RNA levels rather than retardation of translation is responsible for the inhibition of major histocompatibility complex class I antigen presentation by the glutamic acid-rich repeat of herpesvirus saimiri open reading frame 73.

scientific article published on 22 October 2008

Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology

scientific article published on 30 December 2014

Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1

scientific article

Specific oncolytic activity of herpesvirus saimiri in pancreatic cancer cells.

scientific article

Stathmin drives virus-induced metastasis

scientific article published on 4 October 2015

Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57

scientific article

Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach ⬇️

scientific article (publication date: 31 October 2016)

The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.

scientific article

The Herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter

scientific article published on November 2005

The Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein and Its Multiple Roles in mRNA Biogenesis

scientific article published on 20 February 2012

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen ⬇️

scientific article published on April 2017

The Tudor SND1 protein is an mA RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus

scientific article published on 24 October 2019

The activation domain of herpesvirus saimiri R protein interacts with the TATA-binding protein.

scientific article published on December 1999

The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression

scientific article published on September 2000

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility ⬇️

scientific article published on 8 February 2018

The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology

scientific article published on May 2013

The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor SC-35.

scientific article

The herpesvirus saimiri ORF 73 regulatory region provides long-term transgene expression in human carcinoma cell lines

scientific article published on January 2003

The herpesvirus saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases

scientific article published in March 1997

The herpesvirus saimiri ORF73 gene product interacts with host-cell mitotic chromosomes and self-associates via its C terminus

scientific article published in January 2004

The herpesvirus saimiri Rta gene autostimulates via binding to a non-consensus response element.

scientific article published on March 2005

The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters

scientific article published on May 2004

The human herpesvirus-8 ORF 57 gene and its properties

scientific article

The immediate-early gene product encoded by open reading frame 57 of herpesvirus saimiri modulates gene expression at a posttranscriptional level

scientific article published on January 1998

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. ⬇️

scientific article published on 2 March 2018

The open reading frame (ORF) 50a gene product regulates ORF 57 gene expression in herpesvirus saimiri

scientific article published on March 1998

The open reading frame 57 gene product of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export.

scientific article published on December 1999

The prototype gamma-2 herpesvirus nucleocytoplasmic shuttling protein, ORF 57, transports viral RNA through the cellular mRNA export pathway

scientific article published on April 2005

The use of high-frequency ultrasound imaging and biofluorescence for in vivo evaluation of gene therapy vectors ⬇️

scientific article

Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication

scientific article

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes

scientific article published on 19 January 2012

Utilising proteomic approaches to understand oncogenic human herpesviruses (Review). ⬇️

scientific article published on 09 July 2014

Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus

scientific article published on 4 September 2008

X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency

scientific article published on 10 October 2007

gamma-2 Herpes virus post-transcriptional gene regulation

scientific article

m6aViewer: software for the detection, analysis and visualization of N6-methyl-adenosine peaks from m6A-seq/ME-RIP sequencing data ⬇️

scientific article published on 19 July 2017

mA: Widespread regulatory control in virus replication ⬇️

scientific article published on 07 November 2018

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