List of works - Oliver Sieber

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

article

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

article

A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

scientific article

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

scientific article

APC and the three-hit hypothesis

scientific article published on 6 October 2008

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma

article

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

scientific article

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

scientific article published on 3 January 2013

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

scientific article

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

scientific article published on 27 June 2016

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

scientific article published in December 2005

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

scientific article

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

scientific article (publication date: 15 November 2003)

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

scientific article

Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity

scientific article

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

scientific article

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

scientific article published on 22 April 2014

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma

scientific article published on 01 October 2003

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

scientific article published on December 2008

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

scientific article

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

scientific article published on May 2015

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

scientific article published on 22 October 2012

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

scientific article published on 3 February 2016

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

scientific article published on 4 February 2006

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

scientific article published on 16 March 2016

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

scientific article published on October 2008

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

scientific article published on 16 May 2014

Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

article

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

scientific article

Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems

scientific article published on 20 January 2019

FunRich: An open access standalone functional enrichment and interaction network analysis tool

scientific article

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

scientific article

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

scientific article

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

scientific article

Genomic instability--the engine of tumorigenesis?

scientific article published in September 2003

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

scientific article published on May 2003

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study

scientific article

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

scientific article published on 29 June 2016

Immunoscore-has it scored for colon cancer precision medicine?

scientific article published on 01 November 2018

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

scientific article

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

scientific article published on 31 December 2014

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

scientific article

Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner.

scientific article published on 20 February 2018

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

scientific article published on August 2013

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

scientific article published on 15 May 2007

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

scientific article published on March 2012

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

scientific article published on 14 January 2011

Long noncoding RNA LINP1: scaffolding non-homologous end joining.

scientific article published on 18 July 2016

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.

scientific article

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

scientific article published on 07 June 2018

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

scientific article

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

scientific article published on 12 February 2013

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

scientific article (publication date: 27 February 2003)

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

scientific article

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

article

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

scientific article

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

scientific article

New reagents for improved in vitro and in vivo examination of TGF-β signalling

scientific article published on October 2011

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation.

scientific article published in May 2011

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

scientific article published on 30 August 2019

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

scientific article

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

scientific article published on 30 April 2013

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

scientific article published on 30 September 2014

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

scientific article published on 11 May 2007

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

scientific article

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

scientific article

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

scientific article published on 10 November 2011

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

article

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

scientific article

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

scientific article published on 26 April 2016

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

scientific article

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

scientific article

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

scientific article published on 17 September 2013

The TERT variant rs2736100 is associated with colorectal cancer risk

scientific article

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

scientific article

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner

scientific article

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

scientific article

Tissue, cell and stage specificity of (epi)mutations in cancers

scientific article published on 01 August 2005

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

scientific article

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

scientific article published on 11 February 2020

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.

scientific article published on February 2013

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

scientific article

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

scientific article

deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer

scientific article published on 04 September 2018

List of works by Oliver Sieber

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

APC and the three-hit hypothesis

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

Genomic instability--the engine of tumorigenesis?

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

Immunoscore-has it scored for colon cancer precision medicine?

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner.

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Long noncoding RNA LINP1: scaffolding non-homologous end joining.

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

New reagents for improved in vitro and in vivo examination of TGF-β signalling

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation.

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

The TERT variant rs2736100 is associated with colorectal cancer risk

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Tissue, cell and stage specificity of (epi)mutations in cancers