List of works - Oliver Sieber

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

article

FunRich: An open access standalone functional enrichment and interaction network analysis tool

scientific article

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

scientific article (publication date: 27 February 2003)

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

article

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

scientific article

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

scientific article

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

scientific article published on 22 April 2014

Genomic instability--the engine of tumorigenesis?

scientific article published in September 2003

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

scientific article

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

scientific article

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

scientific article published on August 2013

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

scientific article

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

scientific article

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

scientific article

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

scientific article published on 14 January 2011

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

scientific article published in May 2011

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

scientific article published on 17 September 2013

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

scientific article published on 30 April 2013

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

scientific article (publication date: 15 November 2003)

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

scientific article

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

scientific article published on May 2003

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

scientific article published in December 2005

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

scientific article published on 12 February 2013

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

scientific article published on 22 October 2012

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

scientific article

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

scientific article

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

scientific article published on December 2008

Tissue, cell and stage specificity of (epi)mutations in cancers

scientific article published on 01 August 2005

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.

scientific article published on February 2013

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

scientific article published on 27 June 2016

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

scientific article

APC and the three-hit hypothesis

scientific article published on 6 October 2008

The TERT variant rs2736100 is associated with colorectal cancer risk

scientific article

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

scientific article

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

scientific article published on 4 February 2006

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

scientific article

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

scientific article published on October 2008

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

scientific article published on 16 March 2016

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

scientific article

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

scientific article published on 30 September 2014

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

article

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

scientific article

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

scientific article published on 3 January 2013

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

scientific article

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

scientific article

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

scientific article

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

scientific article published on 15 May 2007

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

scientific article

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

scientific article

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

scientific article published on 10 November 2011

List of works by Oliver Sieber

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

Genomic instability--the engine of tumorigenesis?

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

Tissue, cell and stage specificity of (epi)mutations in cancers

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

APC and the three-hit hypothesis

The TERT variant rs2736100 is associated with colorectal cancer risk

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice

Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues.

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13