Search filters

List of works by Javier Gómez-Ambrosi

A beta3-adrenergic agonist increases muscle GLUT1/GLUT4 ratio, and regulates liver glucose utilization in diabetic rats

scientific article published on 01 March 1999

Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation

scientific article published on 19 May 2014

Acute Leptin Administration Increases Hypothalamic Expression of Prepro-orexin mRNA

scientific article published on 01 January 1999

Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats.

scientific article published on 23 December 2016

Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes.

scientific article published on 24 February 2009

Adipokine dysregulation and adipose tissue inflammation in human obesity

scientific article published on 03 August 2018

Adipokines in the treatment of diabetes mellitus and obesity

scientific article published on 20 January 2009

Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation

scientific article published on 22 February 2019

Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk

scientific article published on 5 December 2017

Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases.

scientific article

Adipose tissue immunity and cancer

scientific article

Altered Concentrations in Dyslipidemia Evidence a Role for ANGPTL8/Betatrophin in Lipid Metabolism in Humans.

scientific article published on 29 July 2016

An increase in visceral fat is associated with a decrease in the taste and olfactory capacity.

scientific article

Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control ⬇️

scientific article published on May 15, 2011

Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation

scientific article published on 04 June 2020

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

article

Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

scientific article

Association of plasma acylated ghrelin with blood pressure and left ventricular mass in patients with metabolic syndrome

scientific article published in March 2010

Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI.

scientific article published on 10 March 2011

Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity

scientific article published on 17 May 2011

Body weight- independent variations in HDL-cholesterol following gastric bypass

scientific article published on 29 April 2016

Cardiometabolic Profile Related to Body Adiposity Identifies Patients Eligible for Bariatric Surgery More Accurately than BMI

scientific article published on 22 January 2015

Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome

scientific article published on 23 November 2015

Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism

scientific article published on 18 August 2015

Circulating ANGPTL8/Betatrophin Concentrations Are Increased After Surgically Induced Weight Loss, but Not After Diet-Induced Weight Loss

scientific article published on 14 January 2016

Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women

scientific article published on 14 July 2015

Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans

scientific article published on 19 June 2019

Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes

scientific article published on 22 July 2014

Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss

scientific article published on 4 March 2010

Clinical usefulness of a new equation for estimating body fat.

scientific article published on 16 December 2011

Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities

scientific article published on 28 January 2017

Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans

scientific article published on 13 March 2014

Complement factor H is expressed in adipose tissue in association with insulin resistance

scientific article

Control of body weight: a physiologic and transgenic perspective.

scientific article

Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function

scientific article

Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes

scientific article

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice

scientific article

Disruption of the leptin-insulin relationship in obese men 24 hours after laparoscopic adjustable silicone gastric banding

scientific article published in June 2002

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women

scientific article published on 24 July 2006

Divergent effects of an alpha2-adrenergic antagonist on lipolysis and thermogenesis: interactions with a beta3-adrenergic agonist in rats

scientific article published in July 2001

Do resistin and resistin-like molecules also link obesity to inflammatory diseases?

scientific article published on 01 August 2001

Does body adiposity better predict obesity-associated cardiometabolic risk than body mass index?

scientific article published in February 2015

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

scientific article published on 18 September 2014

Effect of Sleeve Gastrectomy on Osteopontin Circulating Levels and Expression in Adipose Tissue and Liver in Rats

scientific article published in April 2014

Effect of a beta3-adrenergic agonist on liver glucokinase gene expression in alloxan-diabetic rats

scientific article published on 01 March 1999

Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity.

scientific article

Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation.

scientific article

Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation

scientific article published on 04 September 2007

Expression of leptin and adiponectin in the rat oviduct

scientific article published on 12 June 2007

Expression of syntaxin 8 in visceral adipose tissue is increased in obese patients with type 2 diabetes and related to markers of insulin resistance and inflammation

scientific article published on 15 December 2014

Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes

scientific article published on 01 May 2011

FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss

scientific article published on 04 May 2016

Fasting plasma ghrelin concentrations 6 months after gastric bypass are not determined by weight loss or changes in insulinemia

scientific article published in October 2004

Functional Relationship between Leptin and Nitric Oxide in Metabolism

scientific article published on 06 September 2019

GLP-1 Limits Adipocyte Inflammation and Its Low Circulating Pre-Operative Concentrations Predict Worse Type 2 Diabetes Remission after Bariatric Surgery in Obese Patients.

scientific article

Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats.

scientific article

Gene expression profile of omental adipose tissue in human obesity

scientific article published on 20 November 2003

Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes

scientific article

IL-32α-induced inflammation constitutes a link between obesity and colon cancer

scientific article

IPO8 and FBXL10: new reference genes for gene expression studies in human adipose tissue.

scientific article

Identification of liver proteins altered by type 2 diabetes mellitus in obese subjects

scientific article

Immunocytochemical detection of leptin in non-mammalian vertebrate stomach

scientific article published in September 2002

Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats

scientific article published on 14 August 2008

Increase of the Adiponectin/Leptin Ratio in Patients with Obesity and Type 2 Diabetes after Roux-en-Y Gastric Bypass

scientific article published on 03 September 2019

Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss

scientific article published on 14 September 2016

Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer

scientific article

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

scientific article published on 23 May 2009

Increased cardiometabolic risk factors and inflammation in adipose tissue in obese subjects classified as metabolically healthy

scientific article published on 10 July 2014

Increased cardiovascular risk markers in obesity are associated with body adiposity: Role of leptin

scientific article published on 01 June 2006

Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass

scientific article published on 13 October 2010

Increased levels of calprotectin in obesity are related to macrophage content: impact on inflammation and effect of weight loss

scientific article published on 5 July 2011

Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients

scientific article published on 10 November 2011

Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass

scientific article published in March 2006

Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity

scientific article published on 31 July 2012

Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver

scientific article published on 10 April 2008

Influence of waist circumference on the metabolic risk associated with impaired fasting glucose: effect of weight loss after gastric bypass

scientific article published in May 2007

Insulin resistance modulates iron-related proteins in adipose tissue

scientific article published on 04 February 2014

Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade

scientific article published on 2 February 2011

Interactions between an alpha2-adrenergic antagonist and a beta3-adrenergic agonist on the expression of UCP2 and UCP3 in rats

scientific article published in March 2002

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors.

scientific article

Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans

scientific article

Is hyperleptinemia involved in the development of age-related lens opacities?

scientific article

Leptin Therapy Does Not Affect Inflammatory Markers

scientific article published on 01 June 2005

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

scientific article published on 09 September 2014

Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice

scientific article

Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice

scientific article (publication date: 2009)

Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice

scientific article published on 10 July 2015

Leptin expression in the rat ovary depends on estrous cycle

scientific article published in October 2003

Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta

scientific article

Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin II through nitric oxide-dependent mechanisms

scientific article

Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice

scientific article

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

scientific article published on 01 June 1999

Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes.

scientific article

Letter by Gomez-Ambrosi et al regarding article, "clinical assessment and management of adult obesity".

scientific article

Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice

scientific article

Liver, but not adipose tissue PEDF gene expression is associated with insulin resistance

scientific article published on 15 January 2013

Mechanisms linking excess adiposity and carcinogenesis promotion

scientific article

Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament

scientific article

Modulation of Higher-Order Olfaction Components on Executive Functions in Humans

scientific article published on 17 June 2015

Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans

scientific article (publication date: 2013)

Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide

scientific article

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

scientific article published on 24 September 2019

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

scientific article published on 5 June 2017

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue.

scientific article

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

scientific article published on 12 May 2014

Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice

scientific article (publication date: 2014)

Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin

scientific article

Peripheral signalling involved in energy homeostasis control

scientific article published on December 2012

Physical activity in anorexia nervosa: How relevant is it to therapy response?

scientific article published on 21 October 2015

Plasma Osteopontin Levels and Expression in Adipose Tissue Are Increased in Obesity

scientific article published on 26 June 2007

Pre- and postprandial expression of the leptin receptor splice variants OB-Ra and OB-Rb in murine peripheral tissues

scientific article

Preventing obesity. Doctors underestimate obesity

article by Gema Frühbeck et al published 1 January 2003 in The BMJ

Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass

scientific article published in November 2007

RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity

scientific article

Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin

scientific article published in May 2001

Rationale for the existence of additional adipostatic hormones.

scientific article

Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations

scientific article published on 21 October 2004

Relationship between eating styles and temperament in an Anorexia Nervosa, Healthy Control, and Morbid Obesity female sample

scientific article published on 27 January 2014

Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice

scientific article published on 01 August 2002

Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity.

scientific article published on 17 June 2013

Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity.

scientific article published on December 2012

Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats

scientific article published on 19 July 2019

Serum Amyloid A Concentration is Increased in Obese Children and Adolescents

scientific article published on 07 March 2008

Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass.

scientific article

Short- and Long-Term Changes in Gastric Morphology and Histopathology Following Sleeve Gastrectomy in Diet-Induced Obese Rats

scientific article published on 2 February 2012

Short-Term Effects of Sleeve Gastrectomy and Caloric Restriction on Blood Pressure in Diet-Induced Obese Rats

scientific article published on 6 July 2012

Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity.

scientific article published on 22 November 2012

Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats

scientific article published on 6 October 2015

Sleeve Gastrectomy Reduces Blood Pressure in Obese (fa/fa) Zucker Rats

scientific article published on 20 November 2011

Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats.

scientific article published on 3 October 2015

Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats

scientific article published on 4 March 2015

Sleeve gastrectomy induces weight loss in diet-induced obese rats even if high-fat feeding is continued

scientific article published in September 2011

Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions.

scientific article published on 22 July 2015

Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes.

scientific article

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.

scientific article published on 15 February 2018

Targeting the circulating microRNA signature of obesity.

scientific article

The Inhibitory Effect of Leptin on Angiotensin II-Induced Vasoconstriction in Vascular Smooth Muscle Cells Is Mediated via a Nitric Oxide-Dependent Mechanism

scientific article published on 12 October 2006

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity

scientific article published on 16 December 2011

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.

scientific article

The bone-adipose axis in obesity and weight loss.

scientific article published on 19 June 2008

The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus

scientific article

The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects.

scientific article published on 18 June 2009

The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes.

scientific article

The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats

scientific article published on August 2006

The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus.

scientific article published in April 2007

The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow

scientific article published in April 2004

The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training

scientific article published on 14 October 2008

Time-Dependent Effects of a High-Energy-Yielding Diet on the Regulation of Specific White Adipose Tissue Genes

article

Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance

scientific article

Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer

scientific article published on 18 October 2010

Validation of Endogenous Control Genes in Human Adipose Tissue: Relevance to Obesity and Obesity-associated Type 2 Diabetes Mellitus

article

Vasodilator effect of ghrelin in the rat aorta

scientific article

Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome?

scientific article published on January 2007

Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissue

scientific article published on 01 November 2002

[Colour scale percent body fat by CUN-BAE adiposity estimator].

scientific article published on 15 December 2015

Paulina is supported by:

About Paulina

Help