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List of works by Malcolm F. White

A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator

scientific article published on 06 May 2019

A dimeric Rep protein initiates replication of a linear archaeal virus genome: implications for the Rep mechanism and viral replication

scientific article published on 10 November 2010

A novel member of the bacterial-archaeal regulator family is a nonspecific dna-binding protein and induces positive supercoiling

scientific article published on 8 January 2001

A type III CRISPR ancillary ribonuclease degrades its cyclic oligoadenylate activator

A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction

scientific article

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis

scientific article

Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA.

scientific article published on January 2012

An Archaeal Endonuclease Displays Key Properties of Both Eukaryal XPF-ERCC1 and Mus81

scientific article published on 08 December 2004

An acetylase with relaxed specificity catalyses protein N-terminal acetylation in Sulfolobus solfataricus

scientific article

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

scientific article published on 15 January 2020

An archaeal Holliday junction resolving enzyme from Sulfolobus solfataricus exhibits unique properties

scientific article published in January 2000

An archaeal XPF repair endonuclease dependent on a heterotrimeric PCNA

scientific article published on 01 April 2003

An updated evolutionary classification of CRISPR-Cas systems

scientific article

Archaeal Chromatin Organization

article published in 2010

Archaeal DNA repair: paradigms and puzzles

scientific article

Archaeal DNA replication and repair

scientific article

Asymmetric base-pair opening drives helicase unwinding dynamics

scientific article published on 18 October 2019

Backbone and side-chain ¹H, ¹³C and ¹⁵N resonance assignments of the OB domain of the single stranded DNA binding protein from Sulfolobus solfataricus and chemical shift mapping of the DNA-binding interface

scientific article

Bacteria SAVED from Viruses

scientific article published on 01 July 2020

Binding dynamics of a monomeric SSB protein to DNA: a single-molecule multi-process approach.

scientific article

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity

scientific article

CC1, a novel crenarchaeal DNA binding protein

scientific article

CRISPR interference: a structural perspective

scientific article

CRISPR-Cas Systems

article

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus

scientific article published on 6 March 2014

Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system

scientific article published on 20 April 2014

Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA

scientific article

Control of cyclic oligoadenylate synthesis in a type III CRISPR system

scientific article published on 02 July 2018

Cpf1 shape-shifts for streamlined CRISPR cleavage

scientific article published in May 2016

Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends.

scientific article published on 15 November 2012

Crystal ‘Unengineering’: Reducing the Crystallisability of Sulfolobus solfataricus Hjc

Crystallization and preliminary X-ray diffraction studies of Hje, a HolliDay junction resolving enzyme from Sulfolobus solfataricus

scientific article

Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax.

scientific article

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence

scientific article published on 01 September 2019

DNA damage detection by an archaeal single-stranded DNA-binding protein

scientific article

DNA damage: from causes to cures

scientific article

DNA end-directed and processive nuclease activities of the archaeal XPF enzyme

scientific article

DNA-Interacting Characteristics of the Archaeal Rudiviral Protein SIRV2_Gp1.

scientific article

Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba

scientific article published on 15 March 2010

Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales

scientific article

Dissection of the Sequence Specificity of the Holliday Junction Endonuclease CCE1†

scientific article published on 01 May 1998

Distortion of DNA junctions imposed by the binding of resolving enzymes: a fluorescence study

scientific article published in November 2001

Equal rates of repair of DNA photoproducts in transcribed and non-transcribed strands in Sulfolobus solfataricus.

scientific article published on 5 December 2006

Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants

scientific article published on 19 December 2019

Expression and Purification of the CMR (Type III-B) Complex in Sulfolobus solfataricus

scientific article

Expression of apple 1-aminocyclopropane-1-carboxylate synthase in Escherichia coli: kinetic characterization of wild-type and active-site mutant forms.

scientific article

Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase

scientific article

Extensive lysine methylation in hyperthermophilic crenarchaea: potential implications for protein stability and recombinant enzymes

scientific article published on 5 August 2010

Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities

scientific article published on 29 March 2015

Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence

scientific article published on 29 April 2020

High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase

scientific article

High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein

scientific article

Holding it together: chromatin in the Archaea

scientific article

Holliday Junction Resolution Is Modulated by Archaeal Chromatin Componentsin Vitro

scientific article published on 14 November 2001

Homologous recombination in the archaea: the means justify the ends

scientific article published on January 1, 2011

Hot and crispy: CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus

scientific article published on December 2013

Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein

scientific article (publication date: 2 June 2003)

Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition

scientific article published on 18 August 2015

Investigation of the cyclic oligoadenylate signaling pathway of type III CRISPR systems

scientific article published on 12 January 2019

Iron–sulphur clusters in nucleic acid processing enzymes

scientific article published on December 12, 2011

Mechanism of DNA loading by the DNA repair helicase XPD.

scientific article published on 20 February 2016

Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex

scientific article

Multiple Holliday junction resolving enzyme activities in the Crenarchaeota and Euryarchaeota

scientific article published on 01 March 2001

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems

scientific article published on 21 January 2016

Nucleosome mobilization catalysed by the yeast SWI/SNF complex

scientific article (publication date: 19 August 1999)

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging

scientific article published in July 2005

Overexpression, purification, crystallization and data collection of Sulfolobus solfataricus Sso6206, a novel highly conserved protein

scientific article

Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus.

scientific article

PCNA activates the Holliday junction endonuclease Hjc.

scientific article

PCNA and XPF cooperate to distort DNA substrates

scientific article

PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step.

scientific article published on 23 October 2008

Physical and functional interaction of the archaeal single-stranded DNA-binding protein SSB with RNA polymerase

scientific article published on 10 February 2004

Postcards from the edge: structural genomics of archaeal viruses

scientific article published on January 2012

Preliminary crystallographic studies of the double-stranded DNA-binding protein Sso10b from Sulfolobus solfataricus

scientific article published on 21 November 2001

Prespacer processing and specific integration in a Type I-A CRISPR system

scientific article published on 8 December 2017

Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin labeling and PELDOR.

scientific article

Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2

scientific article published on 2 April 2014

Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase

scientific article

Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase

scientific article

Quantitation of Metal Ion and DNA Junction Binding to the Holliday Junction Endonuclease Cce1†

scientific article published on 01 December 1999

Reactions to UV damage in the model archaeon Sulfolobus solfataricus

scientific article

RecA family proteins in archaea: RadA and its cousins.

scientific article

Recognition and manipulation of branched DNA structure by junction-resolving enzymes.

scientific article published on June 1997

Recognition of archaeal CRISPR RNA: No P in the alindromic repeat?

scientific article published in February 2011

Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA.

scientific article

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR-Cas immunity

scientific article published on 21 March 2020

Responses of hyperthermophilic crenarchaea to UV irradiation

scientific article

Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection

scientific article published in 2024

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

scientific article published in Nature

Sequence of the gene encoding phosphoglycerate mutase from Saccharomyces cerevisiae

scientific article

Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

scientific article published on 13 November 2013

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

scientific article

Site-directed Mutagenesis of the Yeast Resolving Enzyme Cce1 Reveals Catalytic Residues and Relationship with the Intron-splicing Factor Mrs1

scientific article published on 01 August 2000

Staphylococcus aureus DinG, a helicase that has evolved into a nuclease

scientific article

Structural and Functional Characterisation of a Conserved Archaeal RadA Paralog with Antirecombinase Activity

scientific article

Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)

scientific article

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

scientific article

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

scientific article published on 24 January 2020

Structure of Alba: an archaeal chromatin protein modulated by acetylation

scientific article

Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus

scientific article

Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing

scientific article

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.

scientific article published on 17 February 2005

Structure of the CRISPR interference complex CSM reveals key similarities with cascade

scientific article published on October 2013

Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains

scientific article

Structure of the DNA Repair Helicase XPD

scientific article

Structure of the archaeal Cascade subunit Csa5

scientific article

Structure of the heterotrimeric PCNA from Sulfolobus solfataricus

scientific article published on 19 September 2006

Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases

scientific article

Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje.

scientific article published on 12 October 2004

Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.

scientific article

TarO: a target optimisation system for structural biology

scientific article

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

scientific article published on 29 June 2020

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

scientific article published on 01 March 2021

The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster

scientific article

The DNA repair helicases XPD and FancJ have essential iron-sulfur domains

scientific article

The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes

scientific article published on 01 November 2008

The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius

scientific article

The Scottish Structural Proteomics Facility: targets, methods and outputs

scientific article

The Structure-selectivity and Sequence-preference of the Junction-resolving Enzyme CCE1 of Saccharomyces cerevisiae

scientific article published on 01 March 1996

The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein

scientific article published on 5 October 2007

The XBP-Bax1 helicase-nuclease complex unwinds and cleaves DNA: implications for eukaryal and archaeal nucleotide excision repair

scientific article

The archaeal XPB protein is a ssDNA-dependent ATPase with a novel partner

scientific article

The crenarchaeal DNA damage-inducible transcription factor B paralogue TFB3 is a general activator of transcription

scientific article

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

scientific article published on 27 April 2020

The endonuclease Hje catalyses rapid, multiple turnover resolution of Holliday junctions.

scientific article published in July 2005

The evolution and mechanisms of nucleotide excision repair proteins

scientific article published on 21 September 2010

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway

scientific article

The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation

scientific article

The junction-resolving enzymes.

scientific article published in June 2001

The resolving enzyme CCE1 of yeast opens the structure of the four-way DNA junction

scientific article published on February 1997

The structural basis of DNA binding by the single-stranded DNA-binding protein from Sulfolobus solfataricus

scientific article

The two analogous phosphoglycerate mutases of Escherichia coli

scientific article published on 01 July 1999

Transcriptional response to DNA damage in the archaeon Sulfolobus solfataricus

scientific article

Two Holliday junction resolving enzymes in Sulfolobus solfataricus

scientific article published on April 2000

Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog

scientific article

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

scientific article

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

scientific article