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List of works by Petr Svoboda

14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3)

scientific article

Agonist-induced internalization of the G protein G11alpha and thyrotropin-releasing hormone receptors proceed on different time scales

scientific article published on August 1998

Agonist-induced transfer of the alpha subunits of the guanine-nucleotide-binding regulatory proteins Gq and G11 and of muscarinic m1 acetylcholine receptors from plasma membranes to a light-vesicular membrane fraction

scientific article

Agonist-induced tyrosine phosphorylation of Gq/G11 alpha requires the intact structure of membrane domains.

scientific article published on March 2005

Altered myocardial Gs protein and adenylyl cyclase signaling in rats exposed to chronic hypoxia and normoxic recovery

scientific article

Arachidonate activates muscle electrogenic sodium pump and brain microsome Na+,K+-ATPase under suboptimal conditions

scientific article

Attenuation of Gs alpha coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters

scientific article published on November 1993

Bleomycin stimulates both membrane (Na+-K+) ATPase and electrogenic (Na+-K+) pump and partially removes the inhibition by vanadium ions

scientific article published in October 1983

Ca2+ responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization.

scientific article published in March 2008

Cardiomegaly induced by pressure overload in newborn rats is accompanied by altered expression of the long isoform of G(s)alpha protein and deranged signaling of adenylyl cyclase

scientific article published in March 2003

Catecholamines and the brain microsomal Na, K-adenosinetriphosphatase--I. Protection against lipoperoxidative damage

scientific article published on 01 March 1981

Catecholamines and the brain microsomal Na, K-adenosinetriphosphatase--II. The mechanism of action

scientific article published on 01 March 1981

Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [3H]-forskolin binding

scientific article published in July 2005

Characterization of dicyclohexylcarbodiimide binding sites in beef-heart mitochondria

scientific article published in August 1979

Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment.

scientific article published on March 1996

Concurrent Compression of Phospholipid Membranes by Calcium and Cholesterol

scientific article published on 23 August 2019

Cytoplasmic membrane fluidity measurements on intact living cells of Bacillus subtilis by fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene

scientific article published on 01 January 1988

Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal

scientific article published on 20 October 2017

Different methods of membrane domains isolation result in similar 2-D distribution patterns of membrane domain proteins

scientific article published in December 2003

Different sensitivity of ATP + Mg + Na (I) and Pi + Mg (II) dependent types of ouabain binding to phospholipase A2.

scientific article published on September 1988

Differentiation of cultured brown adipocytes is associated with a selective increase in the short variant of g(s)alpha protein. Evidence for higher functional activity of g(s)alphaS.

scientific article published in September 2000

Differentiation of dicyclohexylcarbodiimide reactive sites of the ATPase complex bovine heart mitochondria

scientific article published on 01 February 1981

Disruption of the plasma membrane integrity by cholesterol depletion impairs effectiveness of TRH receptor-mediated signal transduction via G(q)/G(11)alpha proteins.

scientific article published on January 2007

Dominant portion of thyrotropin-releasing hormone receptor is excluded from lipid domains. Detergent-resistant and detergent-sensitive pools of TRH receptor and Gqalpha/G11alpha protein.

scientific article published in August 2005

Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments

scientific article published on 19 October 2010

Effect of catecholamines and metal chelating agents on the brain and brown adipose tissue Na,K-ATPase

scientific article

Effect of therapeutic concentration of lithium on live HEK293 cells; increase of Na+/K+-ATPase, change of overall protein composition and alteration of surface layer of plasma membrane

scientific article

Evaluation of the specific dicyclohexylcarbodiimide binding sites in brown adipose tissue mitochondria

scientific article published on 01 February 1981

FLIM studies of 22- and 25-NBD-cholesterol in living HEK293 cells: plasma membrane change induced by cholesterol depletion.

scientific article

Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1α fusion protein; the effect of cholesterol depletion

scientific article

Functional interactions between the alpha1b-adrenoceptor and Galpha11 are compromised by de-palmitoylation of the G protein but not of the receptor

scientific article

G proteins, beta-adrenoreceptors and beta-adrenergic responsiveness in immature and adult rat ventricular myocardium: influence of neonatal hypo- and hyperthyroidism

scientific article published on 01 April 1999

High Efficacy but Low Potency of δ-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.

scientific article published on 18 August 2015

High number of high-affinity binding sites for (-)-[3H]dihydroalprenolol on isolated hamster brown-fat cells. A study of the beta-adrenergic receptors

scientific article published on December 1979

High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.

scientific article published on March 2014

Hormone-induced subcellular redistribution of trimeric G proteins.

scientific article

Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.

scientific article

Increased baclofen-stimulated G protein coupling and deactivation in rat brain cortex during development.

scientific article published in July 2004

Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7.

scientific article

Lipid peroxidation inhibits norepinephrine-stimulated lipolysis in rat adipocytes. Reduction of beta-adreno-ceptor number

scientific article

Long-term agonist stimulation of IP prostanoid receptor depletes the cognate G(s)alpha protein in membrane domains but does not change the receptor level

scientific article published on April 2004

Maturation of rat brain is accompanied by differential expression of the long and short splice variants of G(s)alpha protein: identification of cytosolic forms of G(s)alpha

scientific article

Mechanisms of agonist-induced G-protein elimination

scientific article published on February 1995

Membrane fluidity in Bacillus subtilis. Physical change and biological adaptation

scientific article published on 01 January 1988

Membrane fluidity in Bacillus subtilis. Validity of homeoviscous adaptation.

scientific article published in January 1988

Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidism

scientific article published in January 2001

Methodological aspects of in vitro assessment of bio-accessible risk element pool in urban particulate matter

scientific article published on 16 August 2014

Mg2+-induced changes of lipid order and conformation of (Na+ + K+)-ATPase

scientific article

Micromachined nanocalorimetric sensor for ultra-low-volume cell-based assays

scientific article published in May 2002

Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus.

scientific article

Modulation of adenylyl cyclase activity in young and adult rat brain cortex. Identification of suramin as a direct inhibitor of adenylyl cyclase.

scientific article published in October 2005

Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding.

scientific article

Na+/K+-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cells

scientific article published on 21 February 2019

On the mechanism of catecholamine-induced hyperpolarization of skeletal muscle cells.

scientific article

Ontogenetic development of the G protein-mediated adenylyl cyclase signalling in rat brain

scientific article published on January 2002

Opposing changes of trimeric G protein levels during ontogenetic development of rat brain

scientific article published in January 2002

Ouabain binding, ATP hydrolysis, and Na+,K(+)-pump activity during chemical modification of brain and muscle Na+,K(+)-ATPase

scientific article published in March 1992

Overexpression of the G protein G11alpha prevents desensitization of Ca2+ response to thyrotropin-releasing hormone

scientific article published on January 1999

Plasma membrane cholesterol level and agonist-induced internalization of δ-opioid receptors; colocalization study with intracellular membrane markers of Rab family

scientific article published on 13 July 2016

Plasma-membrane-independent pool of the alpha subunit of the stimulatory guanine-nucleotide-binding regulatory protein in a low-density-membrane fraction of S49 lymphoma cells

scientific article

Prolonged agonist stimulation does not alter the protein composition of membrane domains in spite of dramatic changes induced in a specific signaling cascade

scientific article

Protein alterations induced by long-term agonist treatment of HEK293 cells expressing thyrotropin-releasing hormone receptor and G11alpha protein.

scientific article

Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine.

scientific article published on 14 February 2014

Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10days; comparison with animals exposed to morphine and subsequently nurtured for 20days in the absence of this drug

scientific article

Resolution and identification of Gq/G11alpha and Gialpha/Goalpha proteins in brown adipose tissue: effect of cold acclimation

scientific article published on October 1999

Rotational relaxation rate of 1,6-diphenyl-1,3,5-hexatriene in cytoplasmic membranes of Bacillus subtilis. A new model of heterogeneous rotations

scientific article published on 01 January 1990

Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes

scientific article

Stoicheiometry of dicyclohexylcarbodiimide-ATPase interaction in mitochondria.

scientific article published in April 1982

Stress proteins in the cytoplasmic membrane fraction of Bacillus subtilis.

scientific article

Structure and function of the membrane-integral components of the mitochondrial H+-ATPase

scientific article

Subcellular shifts of trimeric G-proteins following activation of baker's yeast by glucose

scientific article published in January 2001

TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP.

scientific article published on 6 December 2014

The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells

scientific article published on 01 December 2018

The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells

scientific article

The decrease in the short variant of gsalpha protein is associated with an increase in [3H]CGP12177 binding, [3H]ouabain binding and Na, K-ATPase activity in brown adipose tissue plasma membranes of cold-acclimated hamsters

scientific article published on 01 February 1999

The effect of detergents on trimeric G-protein activity in isolated plasma membranes from rat brain cortex: correlation with studies of DPH and Laurdan fluorescence

scientific article

The long (Gs(alpha)-L) and short (Gs(alpha)-S) variants of the stimulatory guanine nucleotide-binding protein. Do they behave in an identical way? ⬇️

scientific article published on 01 April 1998

The molecular basis for adrenergic desensitization in hamster brown adipose tissue: uncoupling of adenylate cyclase activation

scientific article published on 01 January 1984

The role of carboxyl groups of Na+/K+-ATPase in the interaction with divalent cations

scientific article published on 01 November 1988

The short and long forms of the alpha subunit of the stimulatory guanine-nucleotide-binding protein are unequally redistributed during (-)-isoproterenol-mediated desensitization of intact S49 lymphoma cells

scientific article published on November 1994

Thyrotropin-releasing hormone-induced depletion of G(q)alpha/G(11)alpha proteins from detergent-insensitive membrane domains

scientific article

Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal

scientific article published on 4 October 2011

Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes

scientific article published on 21 May 2018

Vanadyl (VO2+) and vanadate (VO-3) ions inhibit the brain microsomal Na,K-ATPase with similar affinities. Protection by transferrin and noradrenaline

scientific article published in August 1984

Vanadyl (VO2+) induced lipoperoxidation in the brain microsomal fraction is not related to VO2+ inhibition of Na,K-ATPase

scientific article published in August 1984

Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and gqalpha /G11alpha induced by agonist stimulation

scientific article published on June 1999

δ-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains

article published in 2003

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