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List of works by Antonio Costanzo

A feedback regulatory loop between p63 and Dlx3: implications for epidermal differentiation.

scientific article published on 15 April 2009

A myogenic differentiation checkpoint activated by genotoxic stress

scientific article published on 4 November 2002

A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes.

scientific article published in October 2005

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

scientific article published on 26 April 2010

A role of p73 in mitotic exit.

scientific article published on 28 June 2005

A symphony of regulations centered on p63 to control development of ectoderm-derived structures

scientific article published on 22 May 2011

Actinic keratosis treated with an immune response modifier: a case report of six patients

scientific article published in November 2003

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

scientific article published on January 1997

Adalimumab for severe psoriasis and psoriatic arthritis: an open-label study in 30 patients previously treated with other biologics

scientific article published on 18 June 2007

Adalimumab for the treatment of severe psoriasis and psoriatic arthritis

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

scientific article published on 01 May 1999

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

scientific article published on November 2003

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

scientific article published on 01 October 1998

Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

scientific article

CD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism.

scientific article

CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters.

scholarly article

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain.

scientific article published on 24 October 2009

Characterization of the hepatitis B virus transactivators: a possible direct role of the virus in the development of hepatocellular carcinoma

scientific article published on January 1993

Claudin-1 is a p63 target gene with a crucial role in epithelial development

scientific article

Clinical similarity of biosimilar ABP 501 to adalimumab in the treatment of patients with moderate to severe plaque psoriasis: A randomized, double-blind, multicenter, phase III study.

scientific article

Clinical similarity of the biosimilar ABP 501 compared with adalimumab after single transition: long-term results from a randomized controlled, double-blind, 52-week, phase III trial in patients with moderate-to-severe plaque psoriasis

scientific article published on 28 July 2017

Consecutive use of different biological therapies in the treatment of psoriasis

scientific article published on 06 June 2007

Cross-talks in the p53 family: deltaNp63 is an anti-apoptotic target for deltaNp73alpha and p53 gain-of-function mutants

scientific article published on September 2006

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity.

scientific article published on 20 June 2016

Cytokine expression in circulating T lymphocytes from patients undergoing carotid endarterectomy

scientific article published on 01 April 2003

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

scientific article

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations

scientific article published on 25 February 2014

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.

scientific article

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

scientific article published in January 2002

DNp73α protects myogenic cells from apoptosis

scientific article published on 01 May 2006

DeltaNp63 knockdown mice: A mouse model for AEC syndrome

scientific article

Detection of adalimumab and anti-adalimumab levels by ELISA: clinical considerations.

scientific article published in November 2014

Detection of replicative intermediates of viral RNA in peripheral blood mononuclear cells from chronic hepatitis C virus carriers

scientific article published in January 1993

Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

scientific article

Diagnosis and management of moderate to severe adult atopic dermatitis: a Consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Italian Association of Hospital Dermatologists (ADOI), the Italian Society of Allergy, Asthma a

scientific article published on 14 December 2017

Different applications of monochromatic excimer light in skin diseases

scientific article published in August 2009

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

scientific article published in June 2003

Disease-related and drug-induced skin manifestations in inflammatory bowel disease.

scientific article published on 17 January 2017

Efalizumab

scientific article published on 10 January 2011

Effectiveness End Points in Real-World Studies on Biological Therapies in Psoriasis: Systematic Review with Focus on Drug Survival

scholarly article by Antonio Costanzo et al published 2018 in Dermatology

Effects of insulin on in vitro vascular cell adhesion molecule-1 expression and in vivo soluble VCAM-1 release

scientific article

Efficacy and safety of etanercept in psoriasis after switching from other treatments: an observational study

scientific article published in January 2009

Efficacy of Short-Term Cyclosporine Treatment to Control Psoriasis-Related Events during Efalizumab Therapy

Efficacy of efalizumab in psoriasis patients previously treated with tumour necrosis factor blockers.

scientific article published on 16 April 2009

Efficacy of monochromatic excimer laser radiation (308 nm) in the treatment of early stage mycosis fungoides.

scientific article published in October 2004

Elevated serum levels of 90K/MAC-2 BP predict unresponsiveness to alpha-interferon therapy in chronic HCV hepatitis patients.

scientific article published on August 1996

Emerging treatments in the management of psoriasis: biological targeting with ustekinumab

scientific article published on 22 May 2009

Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin

scientific article (publication date: June 2003)

Erratum: Corrigendum: The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

scientific article published in Nature Communications

Etanercept for the treatment of severe childhood psoriasis

scientific article published on 01 January 2006

Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene.

scientific article published on April 2004

FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.

scientific article published on 24 April 2015

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

article by L Pensati et al published October 1997 in Gastroenterology

Foreword: Seminars in Research 2014 Joint Experiences in Rheumatology and Dermatology

scientific article published on September 2016

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis.

scientific article published on 16 January 2016

Genetic variations in IL6 and IL12B decreasing the risk for psoriasis.

scientific article published on 17 October 2013

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

scientific article

HLA-C*06 and psoriasis: susceptibility, phenotype, course and response to treatment

scientific article published on 01 April 2018

HLA-C*06 and response to ustekinumab in Caucasian patients with psoriasis: Outcome and long-term follow-up.

scientific article published in February 2016

Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes

scientific article published on 3 January 2006

Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.

scientific article published on January 2007

IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias

scientific article

IL-21 in the pathogenesis and treatment of skin diseases

scientific article published on 15 September 2010

IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia

scientific article published on 25 March 2011

IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis.

scientific article published on 18 December 2015

Increased levels of IL-17 in tear fluid of moderate-to-severe psoriatic patients is reduced by adalimumab therapy

scientific article published on 19 October 2015

Induction of neuronal differentiation by p73 in a neuroblastoma cell line

scientific article

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX

scientific article published on February 1994

Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes.

scientific article published on January 1995

Infliximab in psoriasis and psoriatic arthritis.

scientific article published on January 2013

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis.

scientific article published on 27 February 2017

Label-free and non-invasive discrimination of HaCaT and melanoma cells in a co-culture model by hyperspectral confocal reflectance microscopy

article

Living matter observations with a novel hyperspectral supercontinuum confocal microscope for VIS to near-IR reflectance spectroscopy

scientific article

Living with Chronic Spontaneous Urticaria in Italy: A Narrative Medicine Project to Improve the Pathway of Patient Care.

scientific article published on 8 June 2016

Long-term safety of etanercept in psoriasis: Retrospective study focused on infections

scientific article published on September 2016

Long-term treatment of plaque psoriasis with efalizumab: an Italian experience

article

Long-term treatment with adalimumab in psoriatic arthritis: serum adalimumab concentration, immunogenicity and the link with clinical response

scientific article published on September 2016

Long-term ustekinumab treatment for refractory type I pityriasis rubra pilaris.

scientific article published on 30 March 2013

MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.

scientific article published on 7 February 2006

Measuring psoriatic disease in clinical practice. An expert opinion position paper.

scientific article published on 27 May 2015

Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation

scientific article published in September 2000

Multidisciplinary Management of Spondyloarthritis-Related Immune-Mediated Inflammatory Disease.

scientific article published on 7 March 2018

Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA): development and validation of a tool for assessment of nail psoriasis outcomes.

scientific article

Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2

scientific journal article

Optimization of systemic treatments for chronic plaque psoriasis. Recommendations for switching and transitioning

scientific article published on December 2013

PSORS2 Markers Are Not Associated with Psoriatic Arthritis in the Italian Population

article

Patient-relevant needs and treatment goals in nail psoriasis

scientific article

Patients with Moderate to Severe Plaque Psoriasis: One Year after the European Medicines Agency Recommendation of Efalizumab Suspension

scientific article published on 13 April 2011

Pharmacogenetics of psoriasis:HLA-Cw6but notLCE3B/3Cdeletion norTNFAIP3polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab

article

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

scientific article

Prevalence and genomic variability of transfusion transmitted virus in Italian cryptogenic chronic liver disease and healthy blood donors.

scientific article

Professor Sergio Chimenti: 1949-2016.

scientific article

Programmed cell death in the skin.

scientific article published on January 2015

Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic target.

scientific article published on August 2012

Psoriasis: from pathogenesis to novel therapeutic approaches ⬇️

scientific article published on January 1, 2011

Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population.

scientific article

Psychiatric comorbidity and suicidal ideation in psoriasis, melanoma and allergic disorders

scientific article

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

scientific journal article

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.

scientific article published on 23 November 2007

Resistance to Fas-mediated apoptosis in human hepatoma cells

scientific article

Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients.

scientific article published on 16 February 2017

S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

scientific article published on September 2016

Safety and efficacy study on etanercept in patients with plaque psoriasis

scientific article published on 01 January 2005

Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: SUPREME study

scientific article published on 14 August 2018

Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo.

scientific article published on 3 April 2017

Structure, function and regulation of p63 and p73.

scientific article

Suicide risk and psychiatric comorbidity in patients with psoriasis.

scientific article published on September 2016

Superficial and nodular basal cell carcinomas treated with an immune response modifier: a report of seven patients.

scientific article published on November 2003

Systemic Therapy of Primary Cutaneous B-cell Lymphoma, Marginal Zone Type, with Rituximab, a Chimeric Anti-CD20 Monoclonal Antibody

scientific article published on 01 June 2001

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy

scientific article

TRIM8 and p53: making the right decision

scientific article published in February 2012

Targeted therapy in nonmelanoma skin cancers.

scientific article published on 03 May 2011

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.

scientific article published on 26 June 2008

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

scientific article

The impact of methodological approaches for presenting long-term clinical data on estimates of efficacy in psoriasis illustrated by three-year treatment data on infliximab

scientific article

The mechanistic basis for psoriasis immunopathogenesis: translating genotype to phenotype. Report of a workshop, Venice, 2012.

scientific article published on August 2013

The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting.

scientific article published on 27 October 2009

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

scientific article

The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene.

scientific article

The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway

scholarly article

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

scientific article

Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study on a large series of cases

scientific article

Towards a targeted therapy for pyoderma gangrenosum

scientific article published in November 2015

Treasure or artifact: a decade of p63 research speaks for itself.

scientific article published on January 2010

Treatment of vitiligo with the 308 nm excimer laser.

scientific article

Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.

scientific article

Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells

scientific article

Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stre

scientific article published on October 1997

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

scientific article

Use of biological drugs in patients with psoriasis and psoriatic arthritis in Italy: Results from the PSONG survey

scientific article

Ustekinumab for treatment of plaque psoriasis in a patient with Down syndrome.

scientific article published in August 2012

Ustekinumab treatment of erythrodermic psoriasis occurring after physical stress: a report of two cases.

scientific article published on 26 September 2013

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

scientific article published in February 2002

Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.

scientific article published on March 2003

What happened after the clinical trials: long-term safety and efficacy of ustekinumab in daily clinical practice.

scientific article

[Ashy dermatosis: clinico-pathological associations in two cases]

scientific article published on 01 September 2008

deltaEF1 repressor controls selectively p53 family members during differentiation.

scientific article published in November 2005

p63 and p73 transactivate differentiation gene promoters in human keratinocytes

scientific article published on June 2000

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.

scientific article published on 18 February 2013

p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis

scientific article

p73 is regulated by phosphorylation at the G2/M transition.

scientific article published on 13 August 2003

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