List of works - S Rocha

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

scientific article published on March 2004

Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection

scientific article

Analysis of global RNA synthesis at the single cell level following hypoxia

scientific article

Antagonistic crosstalk between APC and HIF-1α.

scientific article published on 15 May 2011

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

scientific article published on 7 December 2015

Cell cycle progression in response to oxygen levels.

scientific article published on 25 May 2014

Ceramide Induces CytochromecRelease from Isolated Mitochondria

scientific article published in Journal of Biological Chemistry

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

scientific article

Cezanne regulates E2F1-dependent HIF2α expression

scientific article

Chromatin and oxygen sensing in the context of JmjC histone demethylases

scientific article

Chromatin as an oxygen sensor and active player in the hypoxia response.

scientific article published on 08 September 2011

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

scientific article published on January 2006

Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia

scientific article published on April 2015

Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines

scientific article

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21.

scientific article published on July 2013

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex

scientific article

Further insights into the mechanism of hypoxia-induced NFκB. [corrected].

scientific article published on 15 March 2011

Gene regulation under low oxygen: holding your breath for transcription.

scientific article published on 10 July 2007

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-

scientific article published on 30 August 2017

Grow₂: the HIF system, energy homeostasis and the cell cycle

scientific article published on 10 January 2014

HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs.

scientific article

HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

scientific article

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6

scientific article published on 24 April 2020

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

scientific article published on 22 October 2012

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

scientific article published on 10 October 2017

Hypoxia Induced NF-κB

scientific article

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster

scientific article

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms.

scientific article published on 22 April 2018

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.

scientific article published on 9 May 2017

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

scientific article published on 14 March 2019

IKK and NF-?B-mediated regulation of Claspin impacts on ATR checkpoint function.

scientific article published in May 2012

IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function

scientific article

Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21

scientific article

Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation

scientific article

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

scientific article

JmjC histone demethylases act as chromatin oxygen sensors

scientific article published on 07 May 2019

KDM2 Family Members are Regulated by HIF-1 in Hypoxia

scientific article

Mechanism of hypoxia-induced NF-kappaB.

scientific article published on 9 August 2010

NF-κB and HIF crosstalk in immune responses

scientific article

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

scientific article

Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser

scientific article published on 01 February 2001

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

scientific article

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

scientific article

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

scientific article (publication date: 4 November 2016)

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

scientific article

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response

scientific article published on 29 January 2019

Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation

scientific article published on June 2003

Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1.

scientific article published on 29 January 2007

Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

scientific article

Regulation of chromatin accessibility by hypoxia and HIF

scientific article published on 01 March 2022

Regulation of gene expression by hypoxia.

scientific article

Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

scientific article

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

scientific article published on 21 September 2006

SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression.

scientific article published on 29 June 2018

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

scientific article

SWI/SNF regulates the cellular response to hypoxia.

scientific article

SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells

scientific article

TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

scientific article published on 08 August 2018

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling ⬇️

scientific article published on January 1, 2013

The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors

scientific article

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

scientific article published on April 2013

The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH ⬇️

scientific article published on September 7, 2011

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

scientific article

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

scientific article published on 7 July 2011

The role of hypoxia in inflammatory disease (review)

scientific article

[Erratum Volume 10, Issue 6, pp. 879–82] Mechanism of hypoxia-induced NF-kappaB

scholarly article published in Cell Cycle

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

scientific article published on 01 July 2003

List of works by S Rocha

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection

Analysis of global RNA synthesis at the single cell level following hypoxia

Antagonistic crosstalk between APC and HIF-1α.

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

Cell cycle progression in response to oxygen levels.

Ceramide Induces CytochromecRelease from Isolated Mitochondria

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

Cezanne regulates E2F1-dependent HIF2α expression

Chromatin and oxygen sensing in the context of JmjC histone demethylases

Chromatin as an oxygen sensor and active player in the hypoxia response.

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia

Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21.

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex

Further insights into the mechanism of hypoxia-induced NFκB. [corrected].

Gene regulation under low oxygen: holding your breath for transcription.

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-

Grow₂: the HIF system, energy homeostasis and the cell cycle

HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs.

HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Hypoxia Induced NF-κB

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms.

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

IKK and NF-?B-mediated regulation of Claspin impacts on ATR checkpoint function.

IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function

Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21

Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

JmjC histone demethylases act as chromatin oxygen sensors

KDM2 Family Members are Regulated by HIF-1 in Hypoxia

Mechanism of hypoxia-induced NF-kappaB.

NF-κB and HIF crosstalk in immune responses

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response

Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation

Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1.

Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

Regulation of chromatin accessibility by hypoxia and HIF

Regulation of gene expression by hypoxia.

Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression.

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

SWI/SNF regulates the cellular response to hypoxia.

SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells

TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling ⬇️

The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH ⬇️

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

The role of hypoxia in inflammatory disease (review)

[Erratum Volume 10, Issue 6, pp. 879–82] Mechanism of hypoxia-induced NF-kappaB

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor