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List of works by John D. Hayes

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

scientific article published on 24 July 2009

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

scientific article published on 27 July 2013

A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism

scientific article published on 01 August 2000

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

scientific article

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

scientific article

Age-dependent change of metabolic capacity and genotoxic injury in rat intestine

scientific article published on May 1998

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

scientific article published on 21 March 2017

Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

scientific article

Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase

scientific article

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

scientific article published on 14 August 2010

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

scientific article published on 16 July 2009

Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter ⬇️

scientific article published on April 1, 2003

Conjugation of Highly Reactive Aflatoxin B1exo-8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters†

scientific article published on 01 March 1997

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

scientific article published in November 2004

Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.

scientific article published on January 1991

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

scientific article published on 23 July 2009

Cut-price knockout?

scholarly article by John D. Hayes published November 1995 in Human & Experimental Toxicology

Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines

scientific article published on March 1998

Decreased hepatic glutathione S-transferase A, AA and L concentration produced by prolonged thyroid hormone administration

scientific article published on 01 August 1988

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways

scientific article

Development of specific radioimmunoassays for the measurement of human hepatic basic and N/A2b glutathione S-transferases

article

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

scientific article

Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity

scientific article published in March 2002

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

scientific article published on 03 August 2015

Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease

scientific article

Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa

scientific article published on 01 January 1991

Erratum to “Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility”

scholarly article published in Biochemical Pharmacology

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

scientific article

Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.

scientific article published on 17 November 2009

Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

scientific article published on April 1995

Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue

scientific article published on 01 December 1990

Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues

scientific article published on 01 January 1989

Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility.

scientific article published in December 2001

Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element

scientific article published on November 2003

Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.

scientific article published on December 2003

Fish and mammalian liver cytosolic glutathione S-transferases: Substrate specificities and immunological comparison

article published in 1989

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

scientific article published on November 2006

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

scientific article published in March 1990

Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry.

scientific article published in July 1989

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

scientific article published on September 1989

Glutathione S-transferase localization in aflatoxin B1-treated rat livers.

scientific article published in June 1990

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility.

scientific article published in September 1991

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects.

scientific article

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

scientific article

Hepatic damage in the rat following administration of thyroxine or triiodothyronine, assessed by measurement of plasma glutathione S-transferase YaYa concentrations

scientific article published on 01 November 1986

Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue

scientific article

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

scientific article

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

scientific article

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

scientific article

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

scholarly article

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

scientific article published in September 2010

Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene

scientific article published on October 1993

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

scientific article published on 01 November 1995

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

scientific article

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

scientific article published on 16 September 2008

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

scientific article

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

scientific article (publication date: 13 June 2003)

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

scientific article published on 13 November 2009

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

scientific article

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

scientific article

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

scientific article published on May 2011

Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration

scientific article published on November 1997

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

scientific article published on 21 December 2010

Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs.

scientific article published in December 1992

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention ⬇️

scientific article published on December 28, 2001

Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide ⬇️

scientific article (publication date: July 1992)

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

scientific article published on 25 March 2009

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

scientific article

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

scientific article

Nomenclature for mammalian soluble glutathione transferases

scientific article published in January 2005

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins

scientific article

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

scientific article

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

scientific article

Nrf2 orchestrates fuel partitioning for cell proliferation

scientific article published in August 2012

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

scientific article published on 21 April 2014

Nrf2, a guardian of healthspan and gatekeeper of species longevity

scientific article

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

scientific article published on 13 July 2016

Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro

scientific article published on September 1992

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

scientific article

Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

article

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

scientific article

Plasma glutathione S-transferase measurements by radioimmunoassay: a sensitive index of hepatocellular damage in man.

scientific article

Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents

scientific article published on July 2003

Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress

scientific article published on March 1995

Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues

scientific article published on January 2003

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

scientific article

Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.

scientific article published in June 2000

Purification of acidic glutathione S-transferases from human lung, placenta and erythrocyte and the development of a specific radioimmunoassay for their measurement

article

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.

scientific article published on 23 April 2013

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

scientific article

Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

scientific article published on 16 November 2006

Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.

scientific article published in April 1998

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

scientific article published on 18 January 2011

Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.

scientific article published on 14 January 2010

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

scientific article

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w ⬇️

scholarly article by Paul Meakin published in September 2014

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

scientific article published on 3 April 2015

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

scientific article published on 3 August 2015

The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.

scientific article published on December 2007

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

scientific article

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

scientific article published on 16 March 2014

The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence

scientific article

The Primary and Secondary Metabolism of Aflatoxin B1 by Rat Hepatocytes Cultured on Matrigel

scientific article published on 01 March 1994

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

scientific article

The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

scientific article published on 23 October 2010

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

scientific article

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

scientific article

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

scientific article (publication date: 1995)

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

scientific article published on October 2008

The major glutathione S-transferase in salmonid fish livers is homologous to the mammalian pi-class GST

scientific article published on 01 January 1991

The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity

scientific article published on January 2013

The polymorphic expression of neutral glutathione S-transferase in human mononuclear leucocytes as measured by specific radioimmunoassay

scientific article published on 01 November 1987

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

scientific article

Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains

scientific article

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

scientific article (publication date: October 2014)

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

scientific article published on 20 March 2009

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

scientific article

Variations in the glutathione S-transferase subunits expressed in human livers

scientific article published on 01 November 1986

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

scientific article

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