List of works by Steven J. Siegel

A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice

scientific article published on 9 September 2008

A rapid method for creating drug implants: translating laboratory-based methods into a scalable manufacturing process

scientific article

A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia

scientific article published on 01 March 2004

A unique iontophoretic patch for optimal transdermal delivery of sumatriptan

scientific article published on 19 June 2007

Animal models and measures of perceptual processing in schizophrenia.

scientific article

Antipsychotic-like properties of phosphodiesterase 4 inhibitors: evaluation of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with auditory event-related potentials and prepulse inhibition of startle

scientific article

Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia

scientific article

Attitudes of patients and family members towards implantable psychiatric medication

scientific article published on 20 June 2008

Brain activity and emotional processing in smokers treated with varenicline

scientific article published on 20 April 2011

Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice

scientific article

Cellular and circuit models of increased resting-state network gamma activity in schizophrenia

scientific article

Cellular origins of auditory event-related potential deficits in Rett syndrome

scientific article

Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials.

scientific article

Computerized neurocognitive scanning: I. Methodology and validation in healthy people

scientific article

Computerized neurocognitive scanning: II. The profile of schizophrenia.

scientific article

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.

scientific article

Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.

scientific article published on 28 January 2008

Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles

scientific article published on 16 June 2007

Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology

scientific article published on 08 December 2014

Corticosterone modulates auditory gating in mouse

scientific article published in May 2006

Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice

scientific article

Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.

scientific article published in March 2005

Development of an abbreviated schizophrenia quality of life scale using a new method

scientific article published on 17 October 2002

Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice

scientific article

Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia

scientific article

EEG biomarkers of target engagement, therapeutic effect, and disease process

scientific article published on 30 March 2015

Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia

scientific article published on 26 December 2007

Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential

scientific article

Effects of nicotine vary across two auditory evoked potentials in the mouse

scientific article published on 21 February 2006

Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation.

scientific article published in August 1993

Effects of strain, novelty, and NMDA blockade on auditory-evoked potentials in mice

scientific article published on 16 September 2002

Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers

scientific article published on 6 March 2010

Electroencephalographic and early communicative abnormalities in Brattleboro rats.

scientific article published on 20 October 2013

Electroencephalographic changes following direct current deep brain stimulation of auditory cortex: a new model for investigating neuromodulation

scientific article published on February 2013

Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression

scientific article

Evaluation of in vitro release and in vivo efficacy of mPEG-PLA-haloperidol conjugate micelle-like structures

scientific article published in November 2007

Facial emotion recognition in schizophrenia: intensity effects and error pattern

scientific article published in October 2003

Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures

scientific article

From provocation to aggression: the neural network.

scientific article published on 17 October 2017

GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome.

scientific article

GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.

scientific article

Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia

scientific article published on 22 February 2011

Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content

scientific article published on 5 December 2006

In vitro and in vivo demonstration of risperidone implants in mice.

scientific article

In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia

scientific article published on 27 April 2010

Increased patient autonomy through long-term antipsychotic delivery systems for the treatment of schizophrenia

scientific article published on 01 November 2002

Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

scientific article

Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains

scientific article published on November 2003

Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice

scientific article

Ketamine modulates theta and gamma oscillations.

scientific article published in July 2010

Ketamine produces lasting disruptions in encoding of sensory stimuli

scientific article

Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes.

scientific article

Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition

scientific article

Levels-of-processing effect on word recognition in schizophrenia

scientific article

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.

scientific article published on 10 December 2012

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1.

scientific article

Male and female mice differ for baseline and nicotine-induced event related potentials

scientific article published in October 2008

Metabotropic Glutamate Receptor 5 as a Point of Convergence for Models of Obsessive-Compulsive Disorder and Autism Spectrum Disorder.

scientific article published in October 2016

Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.

scientific article

Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity: Implications for schizophrenia prodromal population

scientific article published on 22 October 2014

Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials

scientific article published in January 2005

Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

scientific article published on 30 June 2016

N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia

scientific article published on 28 October 2008

NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders.

scientific article published on 5 July 2012

NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia

scientific article published on 9 January 2012

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions.

scientific article

Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia

scientific article published in November 2003

Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density

scientific article published on 6 February 2012

Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures

scientific article published in November 2006

Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism

scientific article

PDE inhibitors in psychiatry--future options for dementia, depression and schizophrenia?

scientific article

PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome

scientific article

Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits

scientific article

Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine

scientific article published on May 2004

Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.

scientific article published on 21 November 2006

Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications.

scientific article

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

scientific article

Predator odor modulates auditory event-related potentials in mice.

scientific article published in September 2009

Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol

scientific article published in November 2005

Profile of auditory information-processing deficits in schizophrenia

scientific article

Prognostic variables at intake and long-term level of function in schizophrenia.

scientific article published in March 2006

Psychiatric health care provider attitudes towards implantable medication

scientific article

Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability

scientific article

Resurgence of long-acting antipsychotic formulations

scientific article published on 01 August 2010

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

scientific article

Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials

scientific article

Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.

scientific article

Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives

scientific article published on 18 September 2006

Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice

scientific article published on 22 May 2012

Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia

scientific article published in June 2002

Symptom and demographic profiles in first-episode schizophrenia.

scientific article

Synthesis and characterization of mPEG-PLA prodrug micelles.

scientific article

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

scientific article

The Drosophila DmGluRA is required for social interaction and memory

scientific article published on 23 May 2013

The Role of Nicotine in Schizophrenia

scientific article published on 21 August 2015

The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components

scientific article

The electrophysiological signature of motivational salience in mice and implications for schizophrenia

scientific article

The roles of glutamate receptors across major neurological and psychiatric disorders

scientific article published on 13 November 2011

The scent of salience--is there olfactory-trigeminal conditioning in humans?

scientific article

Validating γ oscillations and delayed auditory responses as translational biomarkers of autism

scientific article

Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging

scientific article

What can we expect from long-acting formulations for schizophrenia?

scientific article published on 01 August 2011

Zelrix: a novel transdermal formulation of sumatriptan.

scientific article

cAMP response element binding protein phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D₂-like receptor agonist treatment in rats

scientific article

mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism

scientific article

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