List of works - Miklós Sahin-Tóth

A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort

scientific article published on 5 December 2015

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

scientific article published on February 2009

A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.

scientific article

A novel p.Ser282Pro variant is associated with autosomal dominant hereditary pancreatitis

scientific article published on 03 March 2017

A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

scientific article published in Nature Communications

Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.

scientific article published on December 2005

Acute pancreatitis. Evidence-based practice guidelines, prepared by the Hungarian Pancreatic Study Group

scientific article published on February 2015

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

scientific article

Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

scientific article published on 10 September 2019

Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity

scientific article published on 17 October 2011

Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.

scientific article

Autoimmune pancreatitis.Evidence based management guidelines of the Hungarian Pancreatic Study Group

article

Biochemical models of hereditary pancreatitis

scientific article

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

scientific article published on 29 July 2019

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

scientific article published on 09 February 2016

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

scientific article published on 10 November 2009

Channelopathy of the Pancreas Causes Chronic Pancreatitis

scientific article published on 20 March 2020

Chronic pancreatitis.Evidence based management guidelines of the Hungarian Pancreatic Study Group

article

Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group.

scientific article

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

scientific article

Chymotrypsin C (caldecrin) is associated with enamel development

scientific article

Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

scientific article

Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen

scientific article

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

scientific article

Chymotrypsin C mutations in chronic pancreatitis ⬇️

scientific article published on August 1, 2011

Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice

scientific article published on 01 August 2018

Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis

scientific article

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

scientific article published on 29 June 2016

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk ⬇️

scientific article published on September 1, 2012

Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.

scientific article published on 30 March 2017

Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.

scientific article published on 30 October 2012

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

scientific article published on 4 January 2018

Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B

scientific article published on 24 June 2019

Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice

scientific article published on 02 March 2020

Exonic variants affecting pre-mRNA splicing add to genetic burden in chronic pancreatitis. ⬇️

scientific article published on 19 September 2013

Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli

scientific article published on 21 February 2006

Expression of recombinant proteins with uniform N-termini

scientific article published on January 2011

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.

scientific article published on March 2013

Functional significance of SPINK1 promoter variants in chronic pancreatitis.

scientific article published on 19 March 2015

Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis

scientific article

Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis

scientific article published on 20 December 2016

Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway

scientific article

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

scientific article published on September 2015

Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen

scientific article published on 22 April 2005

Genetic risk in chronic pancreatitis: the misfolding-dependent pathway

scientific article published on 24 June 2017

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

scientific article

Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen

scientific article published on 21 November 2001

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

scientific article

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues

scientific article

High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial.

scientific article published on 14 September 2017

Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice

scientific article published on 25 July 2018

Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors ⬇️

scientific article published on September 24, 2003

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

scientific article

Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis

scientific article published on 23 January 2014

Human cationic trypsinogen is sulfated on Tyr154.

scientific article published on November 2006

Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains

scientific article

Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation

scientific article published on 03 February 2020

Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C ⬇️

scientific article published on April 26, 2012

Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).

scientific article published in January 2004

Measuring digestive protease activation in the mouse pancreas

scientific article published on 26 December 2019

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

scientific article published on 26 May 2015

Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.

scientific article published on 11 August 2006

Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis.

scientific article published on 31 October 2008

Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis

scientific article published on 23 December 2016

Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation

scientific article published on 24 May 2007

Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice

scientific article published on 18 November 2019

Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice

scientific article published on 18 June 2019

Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.

scientific article published in December 2017

Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes

scientific article

Pancreatic Cancer Cell Lines Heterozygous for the SPINK1 p.N34S Haplotype Exhibit Diminished Expression of the Variant Allele.

scientific article

Pancreatic cancer.Evidence based management guidelines of the Hungarian Pancreatic Study Group

article

Partial and complete SPINK1 deficiency cause distinct pancreatic phenotypes

scientific article published on 01 December 2017

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis

scientific article published on 28 January 2016

Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis

scientific article

Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation

scientific article published on 13 May 2009

Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice

scientific article published in 2022

Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.

scientific article published on 16 May 2013

SPINK1 Promoter Variants in Chronic Pancreatitis

scientific article published on 4 September 2015

Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis

scientific article

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

scientific article published on 30 September 2015

Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis

scientific article published on May 2007

Smoking and Drinking Synergize in Pancreatitis: Multiple Hits on Multiple Targets.

scientific article

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis

scientific article published in PLoS ONE

The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation.

scientific article published on August 2008

The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen.

scientific article

The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition

scientific article published on 21 June 2005

Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis

scientific article published on 18 April 2016

Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.

scientific article

Trypsinogen hL is not a new member of the human trypsinogen family, but a known mouse ortholog.

scientific article published in June 2003

Trypsinogen isoforms in the ferret pancreas

scientific article published in Scientific Reports

Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.

scientific article

Variants in CPA1 are strongly associated with early onset chronic pancreatitis

scientific article published on 18 August 2013

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis

scientific article

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.

scientific article published on 08 January 2014

[Genetic risk factors in chronic pancreatitis]

scientific article published on 01 September 2008

[Pediatric pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

scientific article published in February 2015

List of works by Miklós Sahin-Tóth

A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.

A novel p.Ser282Pro variant is associated with autosomal dominant hereditary pancreatitis

A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.

Acute pancreatitis. Evidence-based practice guidelines, prepared by the Hungarian Pancreatic Study Group

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity

Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.

Autoimmune pancreatitis.Evidence based management guidelines of the Hungarian Pancreatic Study Group

Biochemical models of hereditary pancreatitis

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

Channelopathy of the Pancreas Causes Chronic Pancreatitis

Chronic pancreatitis.Evidence based management guidelines of the Hungarian Pancreatic Study Group

Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group.

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

Chymotrypsin C (caldecrin) is associated with enamel development

Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

Chymotrypsin C mutations in chronic pancreatitis ⬇️

Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice

Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk ⬇️

Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.

Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B

Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice

Exonic variants affecting pre-mRNA splicing add to genetic burden in chronic pancreatitis. ⬇️

Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli

Expression of recombinant proteins with uniform N-termini

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.

Functional significance of SPINK1 promoter variants in chronic pancreatitis.

Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis

Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis

Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen

Genetic risk in chronic pancreatitis: the misfolding-dependent pathway

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues

High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial.

Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice

Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors ⬇️

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis

Human cationic trypsinogen is sulfated on Tyr154.

Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains

Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation

Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C ⬇️

Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).

Measuring digestive protease activation in the mouse pancreas

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.

Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis.

Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis

Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation

Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice

Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice

Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.

Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes

Pancreatic Cancer Cell Lines Heterozygous for the SPINK1 p.N34S Haplotype Exhibit Diminished Expression of the Variant Allele.

Pancreatic cancer.Evidence based management guidelines of the Hungarian Pancreatic Study Group

Partial and complete SPINK1 deficiency cause distinct pancreatic phenotypes

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis

Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis

Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation

Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice

Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.

SPINK1 Promoter Variants in Chronic Pancreatitis

Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis