List of works by Bo Torben Porse

A Sparsomycin-resistant Mutant ofHalobacterium salinariumLacks a Modification at Nucleotide U2603 in the Peptidyl Transferase Centre of 23 S rRNA

scientific article published in August 1996

A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

scientific article published on 27 May 2010

A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel

scientific article published on December 2003

A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

scientific article published on 01 September 2018

A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA

scientific article

A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

scientific article published on 07 January 2019

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

scientific article published on 3 September 2006

Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

scientific article published on 4 November 2011

Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq

scientific article

Antibiotic inhibition of the movement of tRNA substrates through a peptidyl transferase cavity

scientific article published on November 1995

Assembly of proteins and 5 S rRNA to transcripts of the major structural domains of 23 S rRNA 1 1Edited by D. E. Draper

scientific article published in November 1998

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

scientific article published on 26 October 2015

C/EBPalpha in leukemogenesis: identity and origin of the leukemia-initiating cell

scientific article published on May 2009

C/EBPalpha: a tumour suppressor in multiple tissues?

scientific article

C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.

scientific article

C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner

scientific article published on 3 January 2014

C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors

scientific article published on 9 January 2014

CCAAT enhancer binding protein alpha (CEBPA) biallelic acute myeloid leukaemia: cooperating lesions, molecular mechanisms and clinical relevance

scientific article published on 21 February 2020

Cellular origin of prognostic chromosomal aberrations in AML patients

scientific article published on 11 February 2015

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

scientific article

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.

scientific article

Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

scientific article published on 01 July 2018

Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes. ⬇️

scientific article published on August 1999

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

scientific journal article

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

scientific article published on 01 November 2019

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

scientific article published on September 2015

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

scientific article published on 27 February 2017

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

scientific article published on 01 May 2018

Gene expression profiling in MDS and AML: potential and future avenues.

scientific article published on 29 March 2011

H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

scientific article published on 18 March 2022

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

scientific article published on 16 March 2006

HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

article

HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

scientific article published on 9 November 2012

Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

scientific article published on 26 July 2019

Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils

scientific article published on 7 June 2005

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

scientific article published on 01 July 2018

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

scientific article published on 01 October 2019

Initiation of MLL-rearranged AML is dependent on C/EBPα

scientific article published on 23 December 2013

Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

scientific article

Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors

scientific article published on 2 July 2013

Leukemia â methods and protocols

scientific article published in January 2010

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

scientific article published on 17 July 2018

Lipocalin 2 is protective against E. coli pneumonia

scientific article

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.

scientific article

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

scientific article

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

scientific article published on 17 April 2015

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

scientific article

Mapping Important Nucleotides in the Peptidyl Transferase Centre of 23 S rRNA using a Random Mutagenesis Approach

scientific article published in May 1995

Messenger RNA surveillance: neutralizing natural nonsense

scientific article

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

article

Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics

scientific article published on April 1997

Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

scientific article published on 10 July 2019

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen

scientific article published on 22 January 2008

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

scientific article published on May 2008

Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML.

scientific article published on 16 June 2014

PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

scientific article published on 9 August 2013

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.

scientific article published on 15 January 2012

Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

scientific article published on 19 April 2016

Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome

scientific article published in August 1999

Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

scientific article

Puromycin-rRNA interaction sites at the peptidyl transferase center

scientific article published on May 2000

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

scientific article published on 10 February 2014

Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

scientific article published on June 2013

Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms.

scientific article

Systems biology of neutrophil differentiation and immune response.

scientific article

TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

scientific article

Technical advance: immunophenotypical characterization of human neutrophil differentiation.

scientific article published on 7 June 2011

Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

scientific article published on 12 February 2013

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

scientific article published on 25 May 2018

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

scientific article

The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre.

scientific article

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre 1 1Edited by D. E. Draper

scientific article published in February 1998

The donor substrate site within the peptidyl transferase loop of 23 S rRNA and its putative interactions with the CCA-end of N-blocked aminoacyl-tRNA(Phe).

scientific article

The functional consequences of intron retention: alternative splicing coupled to NMD as a regulator of gene expression

scientific article published on 18 December 2013

The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.

scientific article

The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.

scientific article

The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo

scientific article published on February 2006

The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

scientific article published in Nature Communications

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

scientific article published on 24 November 2015

UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome

scientific article

UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

scientific article

UV-induced modifications in the peptidyl transferase loop of 23S rRNA dependent on binding of the streptogramin B antibiotic, pristinamycin IA.

scientific article published in April 1999

[Basic stem cell biology and cancer]

scientific article published on 01 September 2010

[Transgenic mice as disease models]

scientific article published on 17 February 2003

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

scientific article published on January 2013

shRNA screening identifies JMJD1C as being required for leukemia maintenance

scientific article

spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data

scientific article

Paulina is supported by:

About Paulina

Help