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List of works by Wiep Klaas Smits

#EUROmicroMOOC: using Twitter to share trends in Microbiology worldwide

scientific article published on 01 June 2019

A helicase-containing module defines a family of pCD630-like plasmids in Clostridium difficile

scientific article published on 12 December 2017

A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis.

scientific article published on 27 April 2007

An in silico survey of Clostridioides difficile extrachromosomal elements

scientific article published in 2019

Bistability, epigenetics, and bet-hedging in bacteria

scientific article published on January 2008

C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA

scientific article

Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea

scientific article published on 12 December 2018

Chromosomal replication initiation machinery of low-G+C-content Firmicutes

scientific article published on 13 July 2012

Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase

scientific article published on 05 January 2022

Clostridium difficile infection ⬇️

Complete genome sequence of BS49 and draft genome sequence of BS34A, Bacillus subtilis strains carrying Tn916

scientific article published in February 2015

Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5.

scientific article published on 31 January 2015

Cyclodextrin/Adamantane-Mediated Targeting of Inoculated Bacteria in Mice

scientific article published on 23 February 2021

DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.

scientific article published on 10 January 2017

Fluorescent imaging of bacterial infections and recent advances made with multimodal radiopharmaceuticals

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism

scientific article

Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile

scientific article published on 29 January 2019

Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data

scientific article

Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile

scientific article published on 01 June 2021

Hype or hypervirulence: a reflection on problematic C. difficile strains.

scientific article

Identification of the Unwinding Region in the <i>Clostridioides difficile</i> Chromosomal Origin of Replication

scientific article published on 02 October 2020

Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach

scientific article

Interspecies Interactions between Clostridium difficile and Candida albicans

scientific article (publication date: 9 November 2016)

Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections.

scientific article

Multimodal Tracking of Controlled Staphylococcus aureus Infections in Mice

scientific article published on 02 May 2019

Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo

scientific article published on 4 December 2009

Phenotypic variation in bacteria: the role of feedback regulation

scientific article

Plasmid-mediated metronidazole resistance in Clostridioides difficile

scientific article published on 30 January 2020

Practical observations on the use of fluorescent reporter systems in Clostridioides difficile ⬇️

scholarly article published in 2022

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

scientific article

Primosomal proteins DnaD and DnaB are recruited to chromosomal regions bound by DnaA in Bacillus subtilis

scientific article published on 19 November 2010

Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis

scientific article published on 22 June 2007

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.

scientific article

Redefining the Clostridioides difficile σB Regulon: σB Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide

scientific article published on 16 September 2020

SNP-ing out the differences: Investigating differences between Clostridium difficile lab strains

scientific article

Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media.

scientific article published on September 2006

Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development

scientific article published on May 2005

TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm

scientific article

Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis

scientific article published in July 2007

The Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile

scientific article published on 08 January 2019

The HtrA-like protease CD3284 modulates virulence of Clostridium difficile

scientific article

The Signal Sequence of the Abundant Extracellular Metalloprotease PPEP-1 Can Be Used to Secrete Synthetic Reporter Proteins in Clostridium difficile.

scientific article published on 22 June 2016

The evolving epidemic of Clostridium difficile 630

scientific article published on 27 April 2018

The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis.

scientific article

Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in Bacillus subtilis

scientific article published on June 2005

Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries.

scientific article published on 14 May 2009

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites

scientific article published on 27 September 2011

Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis

scientific article published on November 2004

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD.

scientific article

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