List of works - Akimasa Miyanaga

A molecular design that stabilizes active state in bacterial allosteric L-lactate dehydrogenases

article

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

scientific article published on 23 April 2019

Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis

scientific article published on 06 April 2020

Biochemical and structural analyses of a bacterial endo-β-1,2-glucanase reveal a new glycoside hydrolase family

scientific article published on 7 March 2017

Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6.

scientific article

Biosynthesis of natural products containing β-amino acids.

scientific article

Characterization and Structural Analysis of a Novel exo-Type Enzyme Acting on β-1,2-Glucooligosaccharides from Parabacteroides distasonis

scientific article published in 2018

Characterization of a chimeric enzyme comprising feruloyl esterase and family 42 carbohydrate-binding module

scientific article published on 16 September 2009

Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2).

scientific article published on 7 November 2013

Crystal structure of a family 54 alpha-L-arabinofuranosidase reveals a novel carbohydrate-binding module that can bind arabinose

scientific article

Crystal structure of cobalt-containing nitrile hydratase

scientific article

Crystallization and preliminary X-ray analysis of xylanase B from Clostridium stercorarium

scientific article published on 23 January 2004

Crystallization and preliminary X-ray diffraction analysis of Lin1840, a putative β-glucosidase from Listeria innocua

scientific article published on 25 September 2014

Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.

scholarly article

Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. ⬇️

scientific article

Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria.

scientific article

Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.

scientific article published on 26 June 2009

Expression, purification, crystallization and preliminary X-ray analysis of α-L-arabinofuranosidase B fromAspergillus kawachii

article

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement

scientific article

Function and structure relationships of a β-1,2-glucooligosaccharide-degrading β-glucosidase.

scientific article published on 13 November 2017

Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

scientific article published on 18 November 2019

Functional and Structural Analysis of a β-Glucosidase Involved in β-1,2-Glucan Metabolism in Listeria innocua

scientific article published on 17 February 2016

Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

scientific article published on 02 April 2019

Generation of incednine derivatives by mutasynthesis

scientific article published on 04 June 2020

Genome Mining of the Hitachimycin Biosynthetic Gene Cluster: Involvement of a Phenylalanine-2,3-aminomutase in Biosynthesis

article

Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.

scientific article

Identification, characterization, and structural analyses of a fungal endo-β-1,2-glucanase reveal a new glycoside hydrolase family

scientific article published on 29 March 2019

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

scientific article

Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis.

scientific article published on 9 September 2016

Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans

scientific article

Michael additions in polyketide biosynthesis

article

Molecular Anatomy of the Alkaliphilic Xylanase from Bacillus halodurans C-125

scientific article published in 2007

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890

scientific article published on 08 January 2016

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

scientific article published on 01 November 2018

Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis

scientific article published on 13 December 2019

Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

scientific article published on 04 June 2019

Structural Basis for Cyclization Specificity of Two Azotobacter Type III Polyketide Synthases: A SINGLE AMINO ACID SUBSTITUTION REVERSES THEIR CYCLIZATION SPECIFICITY

scientific article

Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

scientific article published on 13 June 2018

Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria

scientific article published on 07 September 2018

Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis

scientific article published in 2022

Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester.

scientific article published on 18 May 2017

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Structure and function of polyketide biosynthetic enzymes: various strategies for production of structurally diverse polyketides

scientific article published in November 2017

Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

scientific article published on February 2016

Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis.

scientific article published on 4 September 2017

Substrate specificity of Chondroitinase ABC I based on analyses of biochemical reactions and crystal structures in complex with disaccharides

scientific article published on 01 December 2021

The core of allosteric motion in Thermus caldophilus L-lactate dehydrogenase

scientific article published on 25 September 2014

The crystal structure of D-mandelate dehydrogenase reveals its distinct substrate and coenzyme recognition mechanisms from those of 2-ketopantoate reductase

scientific article

The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

scientific article published on 22 September 2014

The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates

scientific article

The family 42 carbohydrate-binding module of family 54 alpha-L-arabinofuranosidase specifically binds the arabinofuranose side chain of hemicellulose

scientific article

The ternary complex structure of d-mandelate dehydrogenase with NADH and anilino(oxo)acetate.

scientific article published on 18 March 2017

List of works by Akimasa Miyanaga

A molecular design that stabilizes active state in bacterial allosteric L-lactate dehydrogenases

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis

Biochemical and structural analyses of a bacterial endo-β-1,2-glucanase reveal a new glycoside hydrolase family

Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6.

Biosynthesis of natural products containing β-amino acids.

Characterization and Structural Analysis of a Novel exo-Type Enzyme Acting on β-1,2-Glucooligosaccharides from Parabacteroides distasonis

Characterization of a chimeric enzyme comprising feruloyl esterase and family 42 carbohydrate-binding module

Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2).

Crystal structure of a family 54 alpha-L-arabinofuranosidase reveals a novel carbohydrate-binding module that can bind arabinose

Crystal structure of cobalt-containing nitrile hydratase

Crystallization and preliminary X-ray analysis of xylanase B from Clostridium stercorarium

Crystallization and preliminary X-ray diffraction analysis of Lin1840, a putative β-glucosidase from Listeria innocua

Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.

Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. ⬇️

Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria.

Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.

Expression, purification, crystallization and preliminary X-ray analysis of α-L-arabinofuranosidase B fromAspergillus kawachii

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement

Function and structure relationships of a β-1,2-glucooligosaccharide-degrading β-glucosidase.

Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

Functional and Structural Analysis of a β-Glucosidase Involved in β-1,2-Glucan Metabolism in Listeria innocua

Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

Generation of incednine derivatives by mutasynthesis

Genome Mining of the Hitachimycin Biosynthetic Gene Cluster: Involvement of a Phenylalanine-2,3-aminomutase in Biosynthesis

Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.

Identification, characterization, and structural analyses of a fungal endo-β-1,2-glucanase reveal a new glycoside hydrolase family

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis.

Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans

Michael additions in polyketide biosynthesis

Molecular Anatomy of the Alkaliphilic Xylanase from Bacillus halodurans C-125

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis

Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

Structural Basis for Cyclization Specificity of Two Azotobacter Type III Polyketide Synthases: A SINGLE AMINO ACID SUBSTITUTION REVERSES THEIR CYCLIZATION SPECIFICITY

Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria

Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis

Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester.

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Structure and function of polyketide biosynthetic enzymes: various strategies for production of structurally diverse polyketides

Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis.

Substrate specificity of Chondroitinase ABC I based on analyses of biochemical reactions and crystal structures in complex with disaccharides

The core of allosteric motion in Thermus caldophilus L-lactate dehydrogenase

The crystal structure of D-mandelate dehydrogenase reveals its distinct substrate and coenzyme recognition mechanisms from those of 2-ketopantoate reductase

The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates

The family 42 carbohydrate-binding module of family 54 alpha-L-arabinofuranosidase specifically binds the arabinofuranose side chain of hemicellulose

The ternary complex structure of d-mandelate dehydrogenase with NADH and anilino(oxo)acetate.