List of works - Liskin Swint-Kruse

A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

scientific article published on 09 November 2020

AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators

scientific article

Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer.

scientific article published on November 2003

Allostery in the LacI/GalR family: variations on a theme

scientific article

Amino acid positions subject to multiple coevolutionary constraints can be robustly identified by their eigenvector network centrality scores

scientific article

Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.

scientific article

Comparison of simulated and experimentally determined dynamics for a variant of the Lacl DNA-binding domain, Nlac-P.

scientific article

Computational predictors fail to identify amino acid substitution effects at rheostat positions.

scientific article published on 30 January 2017

Data on publications, structural analyses, and queries used to build and utilize the AlloRep database

scientific article

Designed disulfide between N-terminal domains of lactose repressor disrupts allosteric linkage

scientific article published in October 1997

Enzymatic reaction sequences as coupled multiple traces on a multidimensional landscape

scientific article published on 07 February 2008

Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR

scientific article published on April 2002

Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.

scientific article

Functional consequences of exchanging domains between LacI and PurR are mediated by the intervening linker sequence

scientific article published on July 2007

Functionally important positions can comprise the majority of a protein's architecture

scientific article

Homolog comparisons further reconcile in vitro and in vivo correlations of protein activities by revealing over-looked physiological factors

scientific article published on 09 August 2019

Hydrogen bonds and the pH dependence of ovomucoid third domain stability

scientific article published on 01 April 1995

In vivo tests of thermodynamic models of transcription repressor function.

scientific article published on 15 June 2011

Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI function

scientific article published in August 2005

Ligand interactions with lactose repressor protein and the repressor-operator complex: the effects of ionization and oligomerization on binding

scientific article published on 18 June 2006

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein

scientific article published on 28 November 2007

Linker regions of the RhaS and RhaR proteins.

scientific article published on 27 October 2006

Modular, multi-input transcriptional logic gating with orthogonal LacI/GalR family chimeras

scientific article

Multiple co-evolutionary networks are supported by the common tertiary scaffold of the LacI/GalR proteins

scientific article

Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.

scientific article

Perturbation from a distance: mutations that alter LacI function through long-range effects

scientific article published on December 2003

Resmap: automated representation of macromolecular interfaces as two-dimensional networks

scientific article published on 24 May 2005

RheoScale: A tool to aggregate and quantify experimentally determined substitution outcomes for multiple variants at individual protein positions

scientific article published on 28 August 2018

Rheostats and toggle switches for modulating protein function

scientific article (publication date: 2013)

Subdividing repressor function: DNA binding affinity, selectivity, and allostery can be altered by amino acid substitution of nonconserved residues in a LacI/GalR homologue

scientific article published on 11 July 2008

Temperature and pH dependences of hydrogen exchange and global stability for ovomucoid third domain

scientific article published on 01 January 1996

The strengths and limitations of using biolayer interferometry to monitor equilibrium titrations of biomolecules

scientific article published on 23 January 2020

Thermodynamics, protein modification, and molecular dynamics in characterizing lactose repressor protein: strategies for complex analyses of protein structure-function.

scientific article

Using Evolution to Guide Protein Engineering: The Devil IS in the Details

scientific article published on July 2016

Using networks to identify fine structural differences between functionally distinct protein states

scientific article

List of works by Liskin Swint-Kruse

A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators

Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer.

Allostery in the LacI/GalR family: variations on a theme

Amino acid positions subject to multiple coevolutionary constraints can be robustly identified by their eigenvector network centrality scores

Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.

Comparison of simulated and experimentally determined dynamics for a variant of the Lacl DNA-binding domain, Nlac-P.

Computational predictors fail to identify amino acid substitution effects at rheostat positions.

Data on publications, structural analyses, and queries used to build and utilize the AlloRep database

Designed disulfide between N-terminal domains of lactose repressor disrupts allosteric linkage

Enzymatic reaction sequences as coupled multiple traces on a multidimensional landscape

Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR

Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.

Functional consequences of exchanging domains between LacI and PurR are mediated by the intervening linker sequence

Functionally important positions can comprise the majority of a protein's architecture

Homolog comparisons further reconcile in vitro and in vivo correlations of protein activities by revealing over-looked physiological factors

Hydrogen bonds and the pH dependence of ovomucoid third domain stability

In vivo tests of thermodynamic models of transcription repressor function.

Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI function

Ligand interactions with lactose repressor protein and the repressor-operator complex: the effects of ionization and oligomerization on binding

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein

Linker regions of the RhaS and RhaR proteins.

Modular, multi-input transcriptional logic gating with orthogonal LacI/GalR family chimeras

Multiple co-evolutionary networks are supported by the common tertiary scaffold of the LacI/GalR proteins

Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.

Perturbation from a distance: mutations that alter LacI function through long-range effects

Resmap: automated representation of macromolecular interfaces as two-dimensional networks

RheoScale: A tool to aggregate and quantify experimentally determined substitution outcomes for multiple variants at individual protein positions

Rheostats and toggle switches for modulating protein function

Subdividing repressor function: DNA binding affinity, selectivity, and allostery can be altered by amino acid substitution of nonconserved residues in a LacI/GalR homologue

Temperature and pH dependences of hydrogen exchange and global stability for ovomucoid third domain

The strengths and limitations of using biolayer interferometry to monitor equilibrium titrations of biomolecules

Thermodynamics, protein modification, and molecular dynamics in characterizing lactose repressor protein: strategies for complex analyses of protein structure-function.

Using Evolution to Guide Protein Engineering: The Devil IS in the Details

Using networks to identify fine structural differences between functionally distinct protein states