List of works by Tim Tolker-Nielsen

A broad range quorum sensing inhibitor working through sRNA inhibition

scientific article

A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

scientific article published in February 2006

A mariner transposon vector adapted for mutagenesis in oral streptococci

scientific article

A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia.

scientific article published on September 2010

A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli

scientific article published on July 1994

A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation

scientific article

Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

scientific article published on 22 December 2015

Advances in nucleic acid-based diagnostics of bacterial infections

scientific article published on 13 July 2007

An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

scientific article published on 23 April 2010

Antibiotic Tolerance and Resistance in Biofilms

scientific article published in 2010

Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer againstPseudomonas aeruginosaPAO1

scientific article published on 01 September 2014

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

scientific article

Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron

scientific article

Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells

scientific article published on May 2000

Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations

scientific article published on 28 November 2009

Bacteria-triggered release of antimicrobial agents.

scientific article published on 29 November 2013

Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.

scientific article published on 13 September 2017

Bacterial biofilm in chronic lesions of hidradenitis suppurativa.

scientific article published on 26 August 2016

Biofilm Development

scientific article published on April 2015

Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants

scientific article

Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa.

scientific article

Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

scientific article

Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

scientific article

Burkholderia cenocepacia H111 Produces a Water-Insoluble Exopolysaccharide in Biofilm: Structural Determination and Molecular Modelling

scientific article published on 02 March 2020

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions

scientific article

Bursting the bubble on bacterial biofilms: a flow cell methodology

scientific article published on January 2012

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

scientific article

CDy14: a novel biofilm probe targeting exopolysaccharide Psl

scientific article published on 01 October 2018

Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

scientific article published in 2021

Cell death in Pseudomonas aeruginosa biofilm development.

scientific article published on August 2003

Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark

scientific article published in August 2010

Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6.

scientific article published on 27 April 2007

Characterization of starvation-induced dispersion in Pseudomonas putida biofilms

scientific article published in June 2005

Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms.

scientific article published on 7 July 2009

Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria

scientific article published on 20 May 2013

Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials

scientific article published on 10 June 2014

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

scientific article

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

scientific article

Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

scientific article

Crystal ball

scientific article published on 01 February 2000

Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa

scientific article published in October 2022

DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus

Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions

scientific article published on 26 August 2009

Development and dynamics of Pseudomonas sp. biofilms

scientific article

Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.

scientific article published on 13 October 2006

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

scientific article (publication date: 21 July 2014)

Distribution, organization, and ecology of bacteria in chronic wounds

scientific article published on 28 May 2008

Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82.

scientific article published on 16 January 2014

Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms

scientific article published on August 2006

Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

scientific article published on 21 July 2008

Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa

scientific article published in May 2007

Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization

scientific article published in April 1997

Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in pseudomonas aeruginosa microbial fuel cells

scientific article published on 20 May 2013

Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP.

scientific article published on August 2015

Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

scientific article

Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy

scientific article

Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

scientific article

Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.

scientific article

Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa

scientific article published on 11 May 2012

Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness.

scientific article published on 7 October 2015

Gauging and Visualizing c-di-GMP Levels in Pseudomonas aeruginosa Using Fluorescence-Based Biosensors.

scientific article published on January 2017

Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure

scientific article

Growing and analyzing biofilms in flow cells

scientific article published in January 2006

Growing and analyzing biofilms in flow chambers

scientific article published on 01 May 2011

HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa

scientific journal article

High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.

scientific article published on 3 May 2017

High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

scientific article published on 21 January 2019

High-Throughput Screening for Compounds that Modulate the Cellular c-di-GMP Level in Bacteria.

scientific article published on January 2017

Identification of LasR ligands through a virtual screening approach

scientific article published on 30 November 2012

Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa

scientific article

Importance of the Exopolysaccharide Matrix in Antimicrobial Tolerance of Pseudomonas aeruginosa Aggregates

scientific article published on 30 January 2017

In silico analyses of metagenomes from human atherosclerotic plaque samples

scientific article published on 3 September 2015

In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells

scientific article

In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

scientific article

In-Frame and Unmarked Gene Deletions in Burkholderia cenocepacia via an Allelic Exchange System Compatible with Gateway Technology.

scientific article published on 20 March 2015

Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

scientific article published on 03 September 2019

Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

scientific article

Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

scientific article published on 25 February 2019

Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

scientific article

Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents

scientific article published on 01 February 1999

Inoculation method could impact the outcome of microbiological experiments.

scientific article published on 21 December 2017

Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

scientific article

Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

scientific article published on 07 April 2010

Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa

scientific article published on 28 February 2008

Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms

scientific journal article

Key Players and Individualists of Cyclic-di-GMP Signaling in

scientific article published on 01 January 2018

Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms

scientific article published on 28 September 2015

Methods for studying biofilm formation: flow cells and confocal laser scanning microscopy

scientific article

Microbial motility involvement in biofilm structure formation--a 3D modelling study.

scientific article published in January 2007

Microbial pathogenesis and biofilm development

scientific article published in January 2005

Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

scientific article

Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa

scientific article

Non-genetic population heterogeneity studied by in situ polymerase chain reaction

scientific article published in March 1998

Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

scientific article published on 7 October 2009

Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

scientific article published on 21 January 2019

P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination

scientific article published on 01 March 2019

PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

scientific article published on January 2014

Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

scientific article

Pattern differentiation in co-culture biofilms formed byStaphylococcus aureusandPseudomonas aeruginosa

article

Pattern formation in Pseudomonas aeruginosa biofilms.

scientific article

Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm

scientific article

Physiological states of individual Salmonella typhimurium cells monitored by in situ reverse transcription-PCR.

scientific article

Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress

scientific article

Plasmid stability: comments on the dimer catastrophe hypothesis

scientific article

Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

scientific article published on 22 October 2015

Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.

scientific article

Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry

scientific article published in May 2023

Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

scientific article published on 25 August 2015

Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate monooxygenase

scientific article

Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

scientific article

Pseudomonas aeruginosa biofilm infections: from molecular biofilm biology to new treatment possibilities.

scientific article published on December 2014

Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis.

scientific article published on 23 April 2009

Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways

scientific article

Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation

scientific article published on 10 April 2018

Pseudomonas aeruginosa: A Model for Biofilm Formation

Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation.

scientific article published on 2 November 2009

Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds.

scientific article

Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

scientific article

Redox protein OsaR (PA0056) regulates <i>dsbM</i> and the oxidative stress response in <i>Pseudomonas aeruginosa</i>

scientific article published on 23 December 2020

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

scientific article published on 17 October 2017

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

scientific article published on 16 April 2017

Regulation of biofilm formation in Pseudomonas and Burkholderia species

scientific article published on 31 March 2014

Report from Eurobiofilms 2011.

scientific article published in November 2011

Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis

scientific article published in July 2007

Role of commensal relationships on the spatial structure of a surface-attached microbial consortium

scientific article

Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium

scientific article published in September 1996

Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

scientific journal article

Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms

scientific article published on 24 October 2017

Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms.

scientific article

Silver-palladium surfaces inhibit biofilm formation

scientific article published on 16 January 2009

Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

scientific article published on 01 November 2019

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators.

scientific article published on 16 January 2014

Spatial Organization of Microbial Biofilm Communities

scientific article published on 01 August 2000

Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.

scientific article

Sub-lethal antimicrobial photodynamic inactivation affects Pseudomonas aeruginosa PAO1 quorum sensing and cyclic di-GMP regulatory systems

scientific article published on 27 July 2019

Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

scientific article

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia.

scientific article published on 7 September 2011

The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

scientific article published on 20 April 2015

The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface ⬇️

scientific article

The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier.

scientific article

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

scientific article published on 15 August 2016

The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species

scientific article published on 4 August 2015

The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

scientific article

The clinical impact of bacterial biofilms

scientific article

The contribution of cell-cell signaling and motility to bacterial biofilm formation

scientific article

The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

scientific article

The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349.

scientific article published on 25 December 2012

The extracellular polysaccharide matrix of Pseudomonas aeruginosa biofilms is a determinant of polymorphonuclear leukocyte responses

scientific article published on 19 October 2020

The implication of Pseudomonas aeruginosa biofilms in infections

scientific article published on April 2011

The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

scientific article published on 20 February 2012

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

scientific article published on 03 May 2019

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

scientific article

Transposon Mutagenesis in Streptococcus Species

scientific article published on 01 January 2019

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

scientific article published on 31 January 2015

Two FtsH Proteases Contribute to Fitness and Adaptation of Pseudomonas aeruginosa Clone C Strains

scientific article published on 09 July 2019

Viable bacteria associated with red blood cells and plasma in freshly drawn blood donations

scientific article

Visualization of specific gene expression in individual Salmonella typhimurium cells by in situ PCR.

scientific article

Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

scientific article published on 01 August 2019

When the PilZ don't work: effectors for cyclic di-GMP action in bacteria.

scientific article published on 21 March 2012

[A possible correlation between periodontitis and ischaemic heart disease] ⬇️

scientific article published on 01 April 2014

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