Search filters

List of works by Daniel Metzger

180 PPARγ Is a Master Regulator of Lactase Production by Intestinal Epithelial Cells

62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March.

scientific article published on 17 February 2012

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

scientific journal article

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor

scientific article

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.

scientific article published on 8 January 2015

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects

scientific article

Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone

scientific article published in June 2008

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles

scholarly article by Bodvael Fraysse published in September 2014

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

scholarly article

Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes.

scientific article

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

scientific article published on 08 June 2019

Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action

scientific article

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives

scholarly article

Androgen signaling negatively controls group 2 innate lymphoid cells

scientific article

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice

scientific article

Autophagy is required to maintain muscle mass

scientific article published in December 2009

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

scientific article published on 24 July 2017

Brain masculinization requires androgen receptor function

scholarly article

Brg1 is required for murine neural stem cell maintenance and gliogenesis

scientific journal article

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine

scientific article (publication date: July 2014)

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue

scientific article

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

scientific article published in Journal of Biological Chemistry

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

scientific article (publication date: 15 September 2000)

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

scientific journal article

Chromatin remodelling complex dosage modulates transcription factor function in heart development

scientific article

Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination

scientific article

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation

scientific article published on 25 September 2014

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection

scientific article published on 25 October 2011

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

scientific article

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma

scientific article published on 24 July 2017

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

scientific article

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.

scientific article published on January 2007

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction

scientific article published on 13 July 2009

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis

scientific article

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

scientific article

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

scientific article published on 07 December 2020

Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.

scientific article published in April 2003

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

scientific article

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

scientific article

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells

scientific article published on June 1997

Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency

scientific journal article

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation

scientific journal article

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo

article published in 1995

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo

scientific article published on 01 May 1995

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

scientific article

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

scientific article published in January 2009

Epidermal γδ T cells sense precancerous cellular dysregulation and initiate immune responses

article

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

scientific article

Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts

scientific article

Expression and function of the human estrogen receptor in yeast.

scientific article

F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression

scientific article

Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia

scientific journal article

Functional role of RXRs and PPARgamma in mature adipocytes.

scientific article published in July 2005

Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse

scientific article published on March 2011

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

scientific article

Genetic dissection of retinoic acid function in epidermis physiology

scientific article published in May 2002

Genetically engineered mouse models of prostate cancer

scientific article

Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse

scientific article published in May 2002

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice

scientific article published on 28 March 2017

Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type

scientific article

Hedgehog signaling regulates sebaceous gland development

scientific article published in December 2003

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

scientific article

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis

scientific article published on 16 June 2017

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

scientific article published on June 2007

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

scholarly article

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

scientific article

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

scientific article published on 6 November 2017

In vivo activation of PPAR target genes by RXR homodimers

scientific article

Inducible Cre/loxP recombination in the mouse proximal tubule

article

Inducible site-specific somatic mutagenesis in mouse hepatocytes

article

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin

scientific article published on 24 July 2008

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice

scientific article

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

scientific article

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

scientific article published on 29 May 2013

LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways

scientific journal article

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

scholarly article

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling

scientific article

LSD1 promotes oxidative metabolism of white adipose tissue

scientific article published on 10 June 2014

Ligand-Independent Actions of Vitamin D Receptor

Ligand-activated site-specific recombination in mice

scientific article

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis

scientific article published in March 2006

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha

scientific journal article

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

scientific article published in Nature Communications

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes

scientific article published on 15 February 2007

Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes

scientific article

Mammary stem cells have myoepithelial cell properties

scientific article

Mechanisms of antihormone action

scientific article

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia

scientific article published on 25 July 2017

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

scientific article

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha

scientific journal article

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

scientific article published on 9 August 2016

Myocytic androgen receptor controls the strength but not the mass of limb muscles

scientific article

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

scientific article published on 01 May 2021

Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-Induced Muscle Hypertrophy and Fiber Type Transition in Male Mice

Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer

scientific article

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

scientific article

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

scientific article published on 20 January 2013

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

scientific article

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons

scientific article published on 26 November 2013

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

scientific article published in December 2009

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

scientific article published on 29 September 2009

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

scientific article published on 12 January 2015

PGC-1β modulates statin-associated myotoxicity in mice

scientific article published on 03 December 2018

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

article by Michael Schuler et al published November 2006 in Cell Metabolism

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

scientific article

Patrolling monocytes control tumor metastasis to the lung.

scientific article

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse

scholarly article

Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation

scientific article published in August 2004

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled

scientific article

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production

scientific article published on 17 August 2012

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy

scientific article

Premature aging in skeletal muscle lacking serum response factor

scientific article

Premature ovarian failure in androgen receptor-deficient mice

scholarly article

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

scientific article

Production and Characterization of Monoclonal Antibodies Recognising Defined Regions of the Human Oestrogen Receptor

article

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity

scientific article

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

scientific article

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate

scientific article

Regeneration of fat cells from myofibroblasts during wound healing.

scientific article published on 5 January 2017

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

scientific article published on August 1997

Relevance of exocytotic glutamate release from retinal glia

scientific article

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium

scientific article

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin

scientific article

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

scientific article

Retinoid signaling in progenitors controls specification and regeneration of the urothelium

scientific article

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen

scientific article published on September 1990

SNF2β-BRG1 is Essential for the Viability of F9 Murine Embryonal Carcinoma Cells ⬇️

scientific article published on October 1, 1997

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development

scientific article

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity

scientific article published on 20 May 2009

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

scholarly article

Senescence controls prostatic neoplasia driven by Pten loss

scientific article published on 23 November 2018

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

scientific article

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver

scholarly article by Sara Della Torre published in August 2018

Site- and time-specific gene targeting in the mouse

scientific article published in May 2001

Site-specific somatic mutagenesis in the retinal pigment epithelium.

scientific article published in May 2002

Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis

scientific article published on 01 April 2019

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.

scientific article published on 26 October 2012

Skeletal myofiber VEGF is essential for the exercise training response in adult mice

scientific article

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

scientific article published in October 2000

Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

scientific article

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling

scientific article published on 6 January 2006

Smoothened is a master regulator of adult liver repair

scientific article published on June 2013

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

scientific article published on December 1997

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells

scientific article

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

scientific article published on December 2004

Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells

scientific article

Suppressive function of androgen receptor in bone resorption

scientific article

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.

scientific article

TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis

scientific article published in September 2005

TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation

scientific article published on 17 May 2007

TRPC3 shapes the ER-mitochondria Ca<sup>2+</sup> transfer characterizing tumour-promoting senescence

scientific article published on 17 February 2022

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

scientific article (publication date: April 2003)

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes

scientific article published in January 2003

Targeted knockout of BRG1 potentiates lung cancer development

scientific article published in May 2008

Targeted somatic mutagenesis in mouse epidermis

scientific article

Targeted somatic mutagenesis in the mouse epidermis

scientific article

Temporal regulation of Cre recombinase activity in neural stem cells

scientific article published in May 2006

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

scholarly article

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis

scientific article published in February 2003

Temporally controlled somatic mutagenesis in smooth muscle

article

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation

scientific journal article

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse

scientific article

Temporally controlled targeted somatic mutagenesis in the mouse brain

scientific article published in December 2001

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

scientific article published on November 1999

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.

scientific article published on 08 August 2013

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

scientific article published on 14 April 2017

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis

scientific article

The histone code reader Spin1 controls skeletal muscle development.

scientific article published on 23 November 2017

The human oestrogen receptor functions in yeast

scientific article published in Nature

The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein

scientific article published on August 1990

The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

scientific article

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells ⬇️

scientific article

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice

scientific article

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures

scientific article

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles

scientific article

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles

scientific article

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma

scholarly article

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

scientific article

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

scientific article

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis

scientific article published on 11 July 2016

Transgenic mice for conditional gene manipulation in astroglial cells.

scientific article published on November 2007

VDR and gemini ligands

scientific article published on September 2015

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease

scientific article published on 22 September 2005

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control

scientific article

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor

scientific article

[How to limit the progression of PTEN-deficient prostatic tumors?]

scientific article published on 01 November 2018

deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

scholarly article by Maxime Parisotto et al published 4 June 2018 in Journal of Experimental Medicine

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

scientific article published in Journal of Biological Chemistry

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor

scientific article published on 7 March 2018

Paulina is supported by:

About Paulina

Help