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List of works by Akifumi Kushiyama

4F2hc stabilizes GLUT1 protein and increases glucose transport activity

scientific article published on 26 January 2011

AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver

scientific article published on 17 September 2008

Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications

scientific article

Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages.

scientific article published on October 2012

Association of gait speed and grip strength with risk of cardiovascular events in patients on haemodialysis: a prospective study

scientific article published on 30 May 2019

Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS.

scientific article

C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus

scientific article published on 5 February 2016

Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways

scientific article published on 5 July 2007

Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis

scientific article published on 24 July 2020

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation

scientific article published on 26 May 2015

Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase

scientific article published on 01 July 2010

Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells

scientific article published on 10 December 2003

Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity

scientific journal article

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice

scientific article published on 12 February 2008

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice

scientific article published on 2 June 2015

Integrator complex plays an essential role in adipose differentiation.

scientific article published on 21 March 2013

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice

scientific article published on 28 January 2016

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8

scientific article published on 01 July 2012

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

scientific article published on 10 June 2015

Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.

scientific article

Linking uric acid metabolism to diabetic complications

scientific article

Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells

scientific article published on 23 October 2008

Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy

scientific article

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model

scientific article published on 26 November 2014

Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

scientific article published on May 2004

Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions

scientific article published on 29 May 2013

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis

scientific article

Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance.

scientific article

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines

scientific article published on 3 June 2015

Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity

scientific article published on 30 July 2010

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit

scientific article published on 14 August 2015

Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.

scientific article published on 12 June 2015

Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice

scientific article published on 4 February 2017

Regulation of gut-derived resistin-like molecule beta expression by nutrients

scientific article

Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet

scientific article published on 21 October 2005

Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia

scientific article published on 18 February 2011

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model

scientific article

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis

scientific article

Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes

scientific article

Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression

scientific article published on 28 February 2006

Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions.

scientific article published on September 2007

Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications

article

Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow

scientific article published on 15 April 2005

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

scientific article published in 2018

The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease

scientific article published on 13 November 2013

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.

scientific article published on 21 May 2015

Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP

scientific article published on 10 January 2019

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus

scientific article published on 19 November 2015

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity

scientific article published on 12 October 2017

Twenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan

scientific article

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice

scientific article published on January 2013

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes

scientific article

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice

scientific article published on 21 September 2019

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