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List of works by Grietje Molema

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension

scientific article published on 14 July 2014

A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets

scientific article published in July 2004

A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo

scientific article

A possible role for spontaneous interleukin-8 production by acute myeloid leukemic cells in angiogenesis related processes: Work in progress

scientific article published on 01 December 2001

A rapid and versatile method for harnessing scFv antibody fragments with various biological effector functions

scientific article published on 01 April 2000

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity.

scientific article published on 08 January 2016

Abrupt reflow enhances cytokine-induced proinflammatory activation of endothelial cells during simulated shock and resuscitation.

scientific article published in October 2014

Absence of in vivo generalized pro-inflammatory endothelial activation in severe, early-onset preeclampsia.

scientific article

Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis

scientific article

Adjunct nitrous oxide normalizes vascular reactivity changes after hemorrhagic shock in mice under isoflurane anesthesia

scientific article published in September 2009

Age-dependent role of microvascular endothelial and polymorphonuclear cells in lipopolysaccharide-induced acute kidney injury.

scientific article

An SV40 large T-antigen immortalized human umbilical vein endothelial cell line for anti-endothelial cell antibody detection.

scientific article published in May 2001

Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting

scientific article published on 01 May 1998

Analyzing Neutrophil Morphology, Mechanics, and Motility in Sepsis: Options and Challenges for Novel Bedside Technologies

scientific article

Angiogenesis in synchronous and metachronous colorectal liver metastases: the liver as a permissive soil.

scientific article published in January 2012

Angiogenesis treatment, new concepts on the horizon

scientific article published on 09 September 2006

Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.

scientific article

Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells

scientific article published on 21 February 2008

Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin

scientific article published on 14 February 2006

Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury

scientific article

Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass

scientific article published on 26 August 2015

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

scientific article

Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells.

scientific article published on 12 July 2013

Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

scientific article published in August 2003

Approaches to lung cancer treatment using the CD3 x EGP-2-directed bispecific monoclonal antibody BIS-1.

scientific article published on November 1997

Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function

scientific article

Bi-specific antibody therapy for the treatment of cancer.

scientific article

CD3 directed bispecific antibodies induce increased lymphocyte-endothelial cell interactions in vitro

scientific article published on January 2000

COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.

scientific article published on March 2009

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

scientific article

Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone

scientific article published on 01 November 2002

Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).

scientific article

Characterization of immortalized human umbilical and iliac vein endothelial cell lines after transfection with SV40 large T-antigen

scientific article

Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657

scientific article published on 26 April 2005

Combining laser microdissection and microRNA expression profiling to unmask microRNA signatures in complex tissues

scientific article published on 17 October 2019

Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation

scientific article published on 13 November 2003

Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas

scientific article published on 01 April 1998

Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma

scientific article

Deeper Penetration into Tumor Tissues and Enhanced in Vivo Antitumor Activity of Liposomal Paclitaxel by Pretreatment with Angiogenesis Inhibitor SU5416

scientific article published on 14 November 2012

Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate

scientific article published in May 2003

Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology

scientific article published on September 2006

Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.

scientific article published in September 2002

Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells

scientific article published on 01 April 2000

Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro

scientific article published on 22 June 2005

Disease-induced drug targeting using novel peptide-ligand albumins

scientific article

Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo

scientific article

Donor brain death reduces survival after transplantation in rat livers preserved for 20 hr.

scientific article published in November 2001

Drug targeting systems for antiviral agents: options and limitations

scientific article published on June 1, 1992

Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade.

scientific article

Early organ-specific endothelial activation during hemorrhagic shock and resuscitation

scientific article

Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes.

scientific article

Effects of Brain Death and Hemodynamic Status on Function and Immunologic Activation of the Potential Donor Liver in the Rat

scientific article published on 01 December 2000

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo.

scientific article

Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.

scientific article

Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting

scientific article published on October 2002

Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

scientific article

Epigenetic Regulation of Tumor Endothelial Cell Anergy: Silencing of Intercellular Adhesion Molecule-1 by Histone Modifications

scientific article published on 01 November 2006

Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels

scientific article

FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms

scientific article published on February 2010

Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: evidence for scavenger receptor heterogeneity

scientific article published in October 1991

Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene

scientific article published on 13 January 2006

Hemorrhagic Shock-induced Endothelial Cell Activation in a Spontaneous Breathing and a Mechanical Ventilation Hemorrhagic Shock Model Is Induced by a Proinflammatory Response and Not by Hypoxia

scientific article published on 01 September 2011

Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features

scientific article published in Journal of Biological Chemistry

Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences.

scientific article published on April 2010

Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.

scientific article published on 20 July 2015

Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications.

scientific article published on January 2010

Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells

article

Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms

scientific article published on 24 May 2019

Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative

scientific article

In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium

scientific article published in January 2003

In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis

scientific article published on 01 July 1999

In vivo characteristics of cationic liposomes as delivery vectors for gene therapy

scientific article

Induction of organ dysfunction and activation of inflammatory markers in donor liver and kidney during hypotensive brain death

scientific article

Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration.

scientific article

Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo

scientific article published on September 2004

Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes

scientific article

Innovations in studying in vivo cell behavior and pharmacology in complex tissues--microvascular endothelial cells in the spotlight.

scientific article

Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems

scientific article published on 19 October 2005

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis

scientific article

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

scientific article published on 29 April 2016

Kidney histopathology in lethal human sepsis

scientific article published on 27 December 2018

Ligand-targeted liposomes directed against pathological vasculature

scientific article published in February 2002

Liposomal targeting of angiogenic vasculature.

scientific article

Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation

scientific article published on July 2011

Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice.

scientific article

Local medial microenvironment directs phenotypic modulation of smooth muscle cells after experimental renal transplantation.

scientific article

MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.

scientific article

Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer.

scientific article published on 02 August 2008

Molecular Pathways of Endothelial Cell Activation for (Targeted) Pharmacological Intervention of Chronic Inflammatory Diseases

scientific article published on 01 January 2005

Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: a role for angiopoietin-1.

scientific article published on August 2010

Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates

article

Neovascularization and vascular markers in a foreign body reaction to subcutaneously implanted degradable biomaterial in mice

scientific article published on January 2002

Off-Pump CABG Surgery Reduces Systemic Inflammation Compared With On-Pump Surgery but Does Not Change Systemic Endothelial Responses

article

One-Step Method for Endothelial Cell Isolation from Large Human Blood Vessels Using Fibrin Glue

scientific article published on 01 June 2000

Oral Carnosine Supplementation Prevents Vascular Damage in Experimental Diabetic Retinopathy

scientific article published on 16 August 2011

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way.

scientific article

Peptide-targeted PEG-liposomes in anti-angiogenic therapy

scientific article

Perioperative Conditions Affect Long-term Hypertrophic Scar Formation

scientific article published on 01 September 2010

Pharmacokinetics and whole body distribution of elastase derived angiostatin(k1-3) in rats

scientific article published on 01 January 2001

Plasma factors in severe early-onset preeclampsia do not substantially alter endothelial gene expression in vitro.

scientific article published on February 2005

Platelet endothelial cell adhesion molecule-1, a putative receptor for the adhesion of Streptococcus pneumoniae to the vascular endothelium of the blood-brain barrier

scientific article

Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury

scientific article published on 07 August 2012

Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins

scientific article published in June 1991

Potential cellular and molecular causes of hypertrophic scar formation.

scientific article published on 25 October 2008

Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.

scientific article published in January 2002

RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL).

scientific article

RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alphavbeta3-expressing endothelial cells

scientific article published in November 2004

Rational design of RGD-albumin conjugates for targeted delivery of the VEGF-R kinase inhibitor PTK787 to angiogenic endothelium.

scientific article

Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys.

scientific article published in November 2003

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice

scientific article published on 01 December 2018

Reply to Letter

scientific article published on 01 January 2015

RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.

scientific article

Rocking the foundations of solid tumor growth by attacking the tumor's blood supply

scientific article published on 01 September 1998

SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells

scientific article published on 25 November 2014

Scanning electron microscopic analysis of endothelial cell coverage and quality in large vessels from multi-organ donors: effects of preservation on endothelial cell integrity

scientific article published in June 2000

Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate.

scientific article

Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.

scientific article published on 7 February 2006

Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability

scientific article

Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname

scientific article published on 09 October 2018

Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function

scientific article

Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease

scientific article published on 20 March 2013

Simultaneous analysis of azidothymidine and its mono-, di- and triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method

scientific article published on 01 August 1992

Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium

scientific article published on 23 April 2007

Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis

scientific article published in October 2009

Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor

scientific article

Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor

scientific article published in Journal of Biological Chemistry

Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro

scientific article published in April 2003

Syntheses and structure-activity relationships for some triazolyl p38α MAPK inhibitors.

scientific article

Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors.

scientific article

Systemic administration of E-selectin-directed dexamethasone liposomes attenuates pulmonary inflammation in a mouse model of ventilator-induced lung injury

scholarly article by MA Hegeman et al published 2009 in Critical Care

Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells

scientific article published on 11 March 2010

Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo

scientific article

Targeted siRNA delivery to diseased microvascular endothelial cells: cellular and molecular concepts.

scientific article published on 15 July 2011

Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study

scientific article published on 18 September 2009

Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System

scientific article

Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study

scientific article published in December 2002

Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate–containing RGD peptide liposomes inhibits experimental arthritis

scientific article published on 01 April 2006

Targeting of drugs to the liver

scientific article published on August 1995

Targeting of liposomes to angiogenic endothelial cells

scientific article published in January 2002

Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver

scientific article published on 01 January 1998

Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation

scientific article published on 01 October 1998

Targeting of the VEGF-kinase inhibitor PTK787 to angiogenic vasculature using RGD-equipped albumin carrier molecules

scientific article published on 01 November 2006

The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy

scientific article published in July 2009

The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin-driven sprouting neovascularization

scientific article published in November 2008

The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme

scientific article published in January 2009

The antiviral protein human lactoferrin is distributed in the body to cytomegalovirus (CMV) infection-prone cells and tissues

scientific article published on January 2002

The flow dependency of Tie2 expression in endotoxemia.

scientific article published on 6 April 2013

The foreign body reaction to a biodegradable biomaterial differs between rats and mice

scientific article published on 01 December 2000

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

scientific article published on 11 November 2019

The renal angiopoietin/Tie2 system in lethal human sepsis

scientific article published on 31 March 2014

The use of bispecific antibodies in tumor cell and tumor vasculature directed immunotherapy.

scientific article

Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans.

scientific article published in May 2011

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.

scientific article

Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications

scientific article published on 8 June 2006

Transporting silence: design of carriers for siRNA to angiogenic endothelium

scientific article published on 24 June 2005

Treatment with IL-2 and IL-12 inhibits tumour cell division in SL2 lymphoma.

scientific article

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

scientific article

Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged

scientific article published on 4 December 2011

Tumor Vasculature Targeted Therapies

scientific article published on 01 June 1998

Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy

scientific article published on 01 January 1997

Tumor vasculature directed drug targeting: applying new technologies and knowledge to the development of clinically relevant therapies.

scientific article

Tumor vessel biology in pediatric intracranial ependymoma

scientific article published on April 2010

Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration

scientific article published on April 2002

VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression.

scientific article

Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.

scientific article

Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells.

scientific article

Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.

scientific article

Vascular heterogeneity in the kidney.

scientific article published on March 2012

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