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List of works by Shirley K. Knauer

A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin α Interaction

A Branched Tripeptide with an Anion-Binding Motif as a New Delivery Carrier for Efficient Gene Transfection

scientific article published on 25 April 2019

A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

scientific article published on 11 February 2020

A Systematic Structure Activity Study of a New Type of Small Peptidic Transfection Vectors Reveals the Importance of a Special Oxo-Anion Binding Motif for Gene Delivery.

scientific article published on 15 September 2017

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.

scientific article published on January 2012

A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery

scientific article published on 01 March 2018

A phosphorylation-acetylation switch regulates STAT1 signaling

scientific article

A tailor-made specific anion-binding motif in the side chain transforms a tetrapeptide into an efficient vector for gene delivery

scientific article published on 22 January 2015

Acetylation of Stat1 modulates NF-kappaB activity

scientific article published on February 2006

Advances towards Cell-Specific Gene Transfection: A Small-Molecule Approach Allows Order-of-Magnitude Selectivity

Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

scientific article published on 23 May 2012

An Old Flame Never Dies: Survivin in Cancer and Cellular Senescence

scientific article published on 03 July 2015

An otoprotective role for the apoptosis inhibitor protein survivin ⬇️

scientific article published on July 1, 2010

Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization

scientific article published in January 2017

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

scientific article published on 01 April 2019

Aromatic Thioethers as Novel Luminophores with Aggregation-Induced Fluorescence and Phosphorescence.

scientific article published on 29 June 2017

Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors

scientific article

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

scientific article published on 21 November 2018

Boosting nanotoxicity to combat multidrug-resistant bacteria in pathophysiological environments

Calcium phosphate increases the encapsulation efficiency of hydrophilic drugs (proteins, nucleic acids) into poly(d,l-lactide-co-glycolide acid) nanoparticles for intracellular delivery

scientific article published on 24 September 2014

Cancer-Cell-Specific Drug Delivery by a Tumor-Homing CPP-Gossypol Conjugate Employing a Tracelessly Cleavable Linker

scientific article published on 30 January 2020

Cell-based analysis of structure-function activity of threonine aspartase 1

scientific article published on 17 November 2010

Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1

scientific article

Cleaving for growth: threonine aspartase 1--a protease relevant for development and disease.

scientific article

Cloning and functional characterization of the guinea pig apoptosis inhibitor protein Survivin

scientific article published on 19 August 2010

Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups

Development of an autofluorescent translocation biosensor system to investigate protein-protein interactions in living cells

scientific article

Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.

scientific article

Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand

Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker

scientific article

Dynamic survivin in head and neck cancer: molecular mechanism and therapeutic potential

scientific article published on September 2007

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

scientific article

Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold Nanoparticles

scientific article

Efficient gene delivery into cells by a surprisingly small three-armed peptide ligand

Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition

scientific article published on April 2015

Exploiting Vitamin D Receptor and Its Ligands to Target Squamous Cell Carcinomas of the Head and Neck

scientific article published in 2023

Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.

scientific article

Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers.

scientific article

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1.

scientific article published on 29 January 2015

Formation of Twisted β-Sheet Tapes from a Self-Complementary Peptide Based on Novel Pillararene-GCP Host-Guest Interaction with Gene Transfection Properties

scientific article published on 12 June 2018

From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor-Targeting Nanocarriers Based on Host-Guest Interaction between a Pillar[5]arene-Based Prodrug and a RGD-Sulfonate Guest

scientific article published on 19 November 2018

Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand

scientific article published on 28 January 2020

Functional characterization of novel mutations affecting survivin (BIRC5)-mediated therapy resistance in head and neck cancer patients

scientific article

GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP

scientific article published on 02 May 2022

Guanidiniocarbonyl pyrrole (GCP) conjugated PAMAM-G2, a highly efficient vector for gene delivery: the importance of DNA condensation.

scientific article published in October 2016

Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis

scientific article

Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation

scientific article published on 7 March 2012

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.

scientific article

Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm

scientific article

Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus-Like Nanoparticles for Nucleic Acid Delivery

scientific article published in 2023

Impact of Secretion-Active Osteoblast-Specific Factor 2 in Promoting Progression and Metastasis of Head and Neck Cancer

scientific article published in 2022

Impact of the nanoparticle-protein corona on colloidal stability and protein structure

scientific article

Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection

scientific article published on 27 November 2015

Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin

scientific article

Introduction of a tailor made anion receptor into the side chain of small peptides allows fine-tuning the thermodynamic signature of peptide-DNA binding

scientific article published on 01 September 2016

Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives

scientific article published on 06 June 2019

Lipofection with estrone-based luminophores featuring aggregation-induced emission properties

Luminescent Amphiphilic Aminoglycoside Probes for Study of Transfection

scientific article published on 07 January 2021

MTOR inhibitor-based combination therapies for pancreatic cancer

scientific article published on 2 January 2018

Mechanisms of nanotoxicity - biomolecule coronas protect pathological fungi against nanoparticle-based eradication

scientific article published on 24 August 2020

Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation.

scientific article published on 14 August 2016

Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide Amphiphile.

scientific article

NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas

scientific article published in July 2008

Nanomaterial–microbe cross-talk: physicochemical principles and (patho)biological consequences

scientific article published on 01 July 2018

Nanoparticle binding attenuates the pathobiology of gastric cancer-associated Helicobacter pylori

scientific article

Nanoparticle decoration impacts airborne fungal pathobiology.

scientific article published on 20 June 2018

Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis

scientific article published on 25 August 2011

Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study

scientific article published on 04 December 2018

New Tools to Probe the Protein Surface: Ultrasmall Gold Nanoparticles Carry Amino Acid Binders

scientific article published on 23 December 2020

No king without a crown--impact of the nanomaterial-protein corona on nanobiomedicine

scientific article

Non-viral transfection vectors: are hybrid materials the way forward?

scientific article published on 16 August 2019

Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential

scientific article (publication date: July 2007)

Nuclear export is essential for the tumor-promoting activity of survivin.

scientific article published on 10 November 2006

Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion

scientific article

Nuclear receptors in head and neck cancer: current knowledge and perspectives

scientific article published on February 2010

Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal

scientific article published on 19 September 2006

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells

scientific article

Peptidyl succinimidyl peptides as taspase 1 inhibitors.

scientific article published on 21 August 2014

Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility

scientific article published in October 2007

Prognostic and therapeutic potential of nuclear receptors in head and neck squamous cell carcinomas

scientific article published on 24 September 2009

Quantitative profiling of the protein coronas that form around nanoparticles

scientific article published on 31 July 2014

RHAMM splice variants confer radiosensitivity in human breast cancer cell lines

scientific article published on 08 February 2016

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

scientific article published on 22 September 2013

SIAH proteins: critical roles in leukemogenesis ⬇️

scientific article published on 05 October 2012

Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1.

scientific article

Simultaneous Rayleigh/Mie and Raman/Fluorescence Characterization of Molecularly Functionalized Colloids by Correlative Single-Particle Real-Time Imaging in Suspension

scientific article published on 7 November 2017

Site-Specific SERS Assay for Survivin Protein Dimer: From Ensemble Experiments to Correlative Single-Particle Imaging.

scientific article

Small Meets Smaller: Effects of Nanomaterials on Microbial Biology, Pathology, and Ecology

scientific article published on 16 July 2018

Smart Glycopolymeric Nanoparticles for Multivalent Lectin Binding and Stimuli-Controlled Guest Release

scientific article published on 10 April 2020

Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers

Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.

scientific article

Supramolecular subphthalocyanine complexes-cellular uptake and phototoxicity

scientific article published on 10 June 2020

Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells.

scientific article

Survivin expression pattern in the intestine of normoxic and ischemic rats.

scientific article

Survivin's dual role: an export's view

scientific article

TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch.

scientific article

TNF-α-Inhibition Improves the Biocompatibility of Porous Polyethylene Implants In Vivo

Targeted induction of apoptosis by chimeric granzyme B fusion proteins carrying antibody and growth factor domains for cell recognition

scientific article published on April 2006

Targeting Taspase1 for cancer therapy--letter

scientific article published on 16 May 2012

Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription

Taspase1: a 'misunderstood' protease with translational cancer relevance.

scientific article

The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function

scientific article

The Taspase1/Myosin1f-axis regulates filopodia dynamics

scientific article published on 05 May 2022

The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer

scientific article

The heterodimerization domains of MLL-FYRN and FYRC--are potential target structures in t(4;11) leukemia

scientific article published on 14 January 2011

The importin-alpha/nucleophosmin switch controls taspase1 protease function

scientific article published on 13 April 2011

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

scientific article published on 12 May 2015

The other side of the corona: nanoparticles inhibit the protease taspase1 in a size-dependent manner

scientific article published on 14 July 2020

The role of survivin for radiation therapy. Prognostic and predictive factor and therapeutic target

scientific article published on November 2007

Therapeutic potential of nuclear receptors

Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

scientific article

Translocation Biosensors-Versatile Tools to Probe Protein Functions in Living Cells.

scientific article published in January 2018

Translocation biosensors to study signal-specific nucleo-cytoplasmic transport, protease activity and protein-protein interactions

scientific article published in July 2005

Umbelliferone Decorated Water-soluble Zinc(II) Phthalocyanines - In Vitro Phototoxic Antimicrobial Anti-cancer Agents

Utilizing combinatorial chemistry and rational design: peptidic tweezers with nanomolar affinity to DNA can be transformed into efficient vectors for gene delivery by addition of a lipophilic tail

scientific article

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin

scientific article

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