List of works - Oliver H Krämer

A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer

scientific article published on 05 December 2011

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.

scientific article published on January 2012

A phosphorylation-acetylation switch regulates STAT1 signaling

scientific article

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

scientific article published on 10 September 2015

Acetylation and sumoylation control STAT5 activation antagonistically

scientific article published on July 2012

Acetylation as a transcriptional control mechanism-HDACs and HATs in pancreatic ductal adenocarcinoma.

scientific article published on June 2011

Acetylation of Stat1 modulates NF-kappaB activity

scientific article published on February 2006

Acetylation of endogenous STAT proteins

scientific article

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

scientific article

Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

scientific article published on 23 May 2012

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells

scientific article published on 16 December 2014

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.

scientific article

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

scientific article published on 8 April 2014

Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment - comparative transcriptome analysis with CHO cDNA microarrays

scientific article

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors

scientific article published on 31 August 2012

Caspase-3 and caspase-6 cleave STAT1 in leukemic cells

scientific article published on April 2014

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

scientific article

Cell-based analysis of structure-function activity of threonine aspartase 1

scientific article published on 17 November 2010

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors

scientific article published on 6 May 2013

Cross talk between stimulated NF-kappaB and the tumor suppressor p53.

scientific article

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

scientific article

Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.

scientific article

Drugging the HDAC6-HSP90 interplay in malignant cells.

scientific article

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

scientific article

Effects of high passage cultivation on CHO cells: a global analysis.

scientific article published on 14 February 2012

Enhancing cell growth and antibody production in CHO cells by siRNA knockdown of novel target genes

scientific article published on 4 December 2013

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published in Nature Communications

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1.

scientific article published on 29 January 2015

Free enthalpies of replacing water molecules in protein binding pockets

scientific article published on 18 December 2012

HDACi--targets beyond chromatin.

scientific article published on April 2009

Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.

scientific article published on 27 July 2014

Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis

scientific article

Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation

scientific article published on 7 March 2012

Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes

scientific article published on 13 January 2020

Histone deacetylases: salesmen and customers in the post-translational modification market.

scientific article published on April 2009

Inhibitors of HDACs--effective drugs against cancer?

scientific article published on March 2010

Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses

scientific article published on 16 January 2013

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter

scientific article

Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells

scientific article published on 09 November 2011

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

scientific article published on 21 August 2014

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors

scientific article

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha

scientific article published on 11 December 2007

NFκB/p53 crosstalk-a promising new therapeutic target.

scientific article published on 15 October 2010

Nuclear export is essential for the tumor-promoting activity of survivin.

scientific article published on 10 November 2006

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells

scientific article

PML promotes MHC class II gene expression by stabilizing the class II transactivator

scientific article

Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation

scientific article published on 14 September 2015

RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.

scientific article published on 19 March 2015

Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity

scientific article published on 9 June 2015

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation

scientific article published on 3 December 2012

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

scientific article published on May 2014

STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published on 22 July 2015

STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis

scientific article published on 19 August 2013

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

scientific article published on March 2015

Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.

scientific article

Survivin and YM155: how faithful is the liaison?

scientific article published on 16 January 2014

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

scientific article published on September 2015

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

scientific article

The importin-alpha/nucleophosmin switch controls taspase1 protease function

scientific article published on 13 April 2011

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

scientific article published on 12 May 2015

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation

scientific article

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

scientific article

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.

scientific article

List of works by Oliver H Krämer

A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.

A phosphorylation-acetylation switch regulates STAT1 signaling

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

Acetylation and sumoylation control STAT5 activation antagonistically

Acetylation as a transcriptional control mechanism-HDACs and HATs in pancreatic ductal adenocarcinoma.

Acetylation of Stat1 modulates NF-kappaB activity

Acetylation of endogenous STAT proteins

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment - comparative transcriptome analysis with CHO cDNA microarrays

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors

Caspase-3 and caspase-6 cleave STAT1 in leukemic cells

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

Cell-based analysis of structure-function activity of threonine aspartase 1

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors

Cross talk between stimulated NF-kappaB and the tumor suppressor p53.

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.

Drugging the HDAC6-HSP90 interplay in malignant cells.

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

Effects of high passage cultivation on CHO cells: a global analysis.

Enhancing cell growth and antibody production in CHO cells by siRNA knockdown of novel target genes

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1.

Free enthalpies of replacing water molecules in protein binding pockets

HDACi--targets beyond chromatin.

Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.

Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis

Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation

Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes

Histone deacetylases: salesmen and customers in the post-translational modification market.

Inhibitors of HDACs--effective drugs against cancer?

Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter

Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha

NFκB/p53 crosstalk-a promising new therapeutic target.

Nuclear export is essential for the tumor-promoting activity of survivin.

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells

PML promotes MHC class II gene expression by stabilizing the class II transactivator

Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation

RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.

Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

STAT3 regulated ARF expression suppresses prostate cancer metastasis

STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.

Survivin and YM155: how faithful is the liaison?

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

The importin-alpha/nucleophosmin switch controls taspase1 protease function

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.