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List of works by Giuseppe Cirino

17-beta-oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism

scientific article

5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

scientific article published on 19 July 2006

A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold

A diclofenac derivative without ulcerogenic properties

scientific article published on 01 May 1994

A new modified thrombin binding aptamer containing a 5'-5' inversion of polarity site

scientific article published on December 2006

A new mouse model of Peyronie's disease: An increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes

scientific article published on 28 May 2008

A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats

scientific article published on 01 August 1995

A novel thrombin binding aptamer containing a G-LNA residue

scientific article published on 08 June 2007

A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats

scientific article

A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues.

scientific article published on September 2007

A role for proteinase-activated receptor-1 in inflammatory bowel diseases.

scientific article published in July 2006

A role for proteinase-activated receptor–1 in inflammatory bowel diseases

A standardized procedure for using human corpus cavernosum strips to evaluate drug activity

scientific article published on 01 November 2000

ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice.

scientific article published on 13 June 2008

Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma

scientific article published in October 2007

Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro

scientific article published on 2 September 2004

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

scientific article published on 21 July 2009

An ex vivo standardized assay to measure human platelet cGMP.

scientific article

Analgesia and cyclo-oxygenase inhibitors

Analysis of protease-activated receptor-1 and -2 in human scar formation.

scientific article

Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage

scientific article published on 3 May 2005

Antiphospholipid antibodies inhibit prostaglandin release by decidual cells of early pregnancy: possible involvement of extracellular secretory phospholipase A2

scientific article published on 01 February 1999

Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo

scientific article published on 13 December 2011

Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2.

scientific article published in November 2003

Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in watanabe heritable hyperlipidemic rabbits

scientific article published on 01 December 1999

Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis.

scientific article published in February 2002

Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice.

scientific article published on 21 July 2008

Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo

scientific article published in January 1999

CL316,243, a selective β3-adrenoceptor agonist, activates protein translation through mTOR/p70S6K signaling pathway in rat skeletal muscle cells.

scientific article

COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

scientific article published on 23 February 2017

Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression

scientific article published on May 2004

Clarithromycin in adult-onset Still's disease: a study of 6 cases

scientific article published on 23 December 2009

Clarithromycin in rheumatoid arthritis: the addition to methotrexate and low-dose methylprednisolone induces a significant additive value--a 24-month single-blind pilot study

scientific article published on 18 July 2013

Comments on: Effects of clarithromycin in patients with active rheumatoid arthritis

scientific article published in November 2007

Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study

scientific article published on 23 March 2007

Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs)

scientific article published on 01 September 1991

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function

scientific article published on January 2013

Dexamethasone inhibition of acute opioid physical dependence in vitro is reverted by anti-lipocortin-1 and mimicked by anti-type II extracellular PLA2 antibodies

scientific article published in January 1997

Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression.

scientific article published on 12 February 2004

Downstream gene activation of the receptor ALX by the agonist annexin A1.

scientific article

Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?

scientific article

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

scientific article published on April 1998

Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro

scientific article published on 01 May 1994

Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2

scientific article published on 01 February 2000

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

scholarly article

Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo

scientific article

Endothelial nitric oxide synthase: the Cinderella of inflammation?

scientific article

Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis

scientific article

Enhanced anti-inflammatory potency of a nitric oxide-releasing derivative of flunisolide: role of nuclear factor-kappaB

scientific article (publication date: September 2004)

Erratum: Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

article

Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.

scientific article published in December 2005

Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature

scientific article published on 11 March 2011

Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

scientific article published in February 2006

Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin

scientific article (publication date: August 2003)

Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

scientific article

Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions.

scientific article published on May 2004

Exercise capacity and cytochrome oxidase activity in muscle mitochondria of COPD patients

scientific article published on 27 August 2009

Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis

scientific article published on 01 July 2007

Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma

scientific article published on 01 June 2005

Fluoroaluminate induces rapid release of endothelin-1 in the isolated perfused arterial and venous vessels of the rat mesentery

scientific article published on 01 March 1997

Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity.

scientific article published on July 1995

Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl est

scientific article published on 30 January 2004

Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat

scientific article published on 29 November 2006

Halipeptins A and B: two novel potent anti-inflammatory cyclic depsipeptides from the Vanuatu marine sponge Haliclona species.

scientific article published in November 2001

Hirulog effect in rat endotoxin shock

scientific article

Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate.

scholarly article

Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma.

scientific article

Human recombinant platelet phospholipase A2 exacerbates poly-l-arginine induced rat paw edema

scientific article published on 01 February 1994

Hydrogen Sulfide-Induced Dual Vascular Effect Involves Arachidonic Acid Cascade in Rat Mesenteric Arterial Bed

scientific article published on 12 January 2011

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

scientific article

Hydrogen sulfide and erectile function: a novel therapeutic target ⬇️

scientific article published on 05 April 2011

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

scientific article

Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.

scientific article published on 15 July 2010

Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation

scientific article (publication date: October 2006)

Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.

scientific article published on December 2010

Hydrogen sulphide is involved in testosterone vascular effect.

scientific article published on 22 May 2008

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

scientific article published on 09 September 2013

Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica

scientific article published on 01 October 1991

Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling

scientific article

Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis

scientific article published in December 2002

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

scientific article published on 01 January 1999

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

article

Increase in the basal tone of guinea pig thoracic aorta induced by ouabain is inhibited by spironolactone canrenone and potassium canrenoate

scientific article published in October 1996

Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats

scientific article published on 01 March 1996

Inflammation-coagulation network: are serine protease receptors the knot?

scientific article

Inhibition of Nitric Oxide–Stimulated Vasorelaxation by Carbon Monoxide-Releasing Molecules

scientific article published on 01 November 2011

Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

scientific article (publication date: October 2005)

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

scientific article

Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function

scientific article

Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

scientific article

Linkage between inflammation and coagulation: An update on the molecular basis of the crosstalk

scientific article published on 01 January 1998

Markedly reduced intestinal toxicity of a diclofenac derivative

article

Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).

scientific article

Mast cell degranulation induced by two phospholipase A2 homologues: Dissociation between enzymatic and biological activities

scientific article published on 01 February 1998

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

scientific article

Minimal structural requirements for agonist activity of PAR-2 activating peptides.

scientific article published in January 2002

Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects

scientific article published on 27 November 2019

Multiple controls in inflammation. Extracellular and intracellular phospholipase A2, inducible and constitutive cyclooxygenase, and inducible nitric oxide synthase

scientific article published on January 1998

Nitric Oxide Related Therapeutic Phenomenon: A Challenging Task

scientific article published on 01 January 2002

Nitric oxide and inflammation

scientific article (publication date: April 2006)

Nitric oxide as a signaling molecule in the vascular system: an overview.

scientific article

Nitric oxide releasing drugs: from bench to bedside

scientific article published in May 2003

Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha

scientific article published on March 1999

Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a new generation of antithrombotics?

Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice

scientific article published on 15 March 2013

PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation

scientific article published on February 2004

Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips.

scientific article published in March 2005

Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning.

scientific article

Pharmacology of erectile dysfunction in man.

scientific article

Plant Metabolites. New Compounds and Anti-Inflammatory Activity of Uncaria tomentosa

article

Platelet cyclic guanosine monophosphate as a biomarker of phosphodiesterase type 5 inhibitor efficacy in the treatment of erectile dysfunction: a randomized placebo-controlled study

scientific article published on 18 September 2009

Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release

scientific article

Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism

scientific article

Protease-activated receptor-2 (PAR2) in cardiovascular system.

scientific article

Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock.

scientific article published on 23 April 2007

Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity

scientific article published on 7 April 2003

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

scientific article

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

scientific article published on 01 July 2001

Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes.

scientific article

Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation

scientific article published on 13 June 2006

Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2

scientific article published on 06 August 2010

Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung

scientific article published in July 1987

Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester

scientific article published in June 1995

Retracted: Endogenous Urotensin II Selectively Modulates Erectile Function through eNOS

retracted article

Retracted: Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo

retracted article

Section Review: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Development of NSAIDs with reduced gastrointestinal and renal toxicity

article

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).

scientific article published on June 2013

Sequential release of TNFalpha and phospholipase A(2) in a rat model of LPS-induced pleurisy.

scientific article published on January 1997

Sildenafil effect on the human bladder involves the L-cysteine/hydrogen sulfide pathway: a novel mechanism of action of phosphodiesterase type 5 inhibitors

scientific article

Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction

scientific article

Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum

scientific article published on 18 October 2005

Sphingosine-1-Phosphate/Sphingosine Kinase Pathway Is Involved in Mouse Airway Hyperresponsiveness

scientific article published on 22 February 2007

Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

scientific article

Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides.

scientific article

Synthesis and antiinflammatory—analgesic profile of 1-methyl-2-(4-X-benzoyl) imidazole-5-carboxylic acids

article published in 1995

Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals

scientific article published on September 2010

Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds.

scientific article published on 26 April 2008

Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage

scientific article published on 01 December 2006

Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage

scientific article published in June 2001

Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.

scientific article

Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.

scientific article published on 25 June 2009

Tedanol: a potent anti-inflammatory ent-pimarane diterpene from the Caribbean Sponge Tedania ignis

scientific article published on 13 September 2009

The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver

scientific article published on 6 March 2006

Thioglycine and l-thiovaline: Biologically active H2S-donors

scientific article published on 27 February 2012

Thrombin Inhibits IFN-γ Production in Human Peripheral Blood Mononuclear Cells by Promoting a Th2 Profile

scientific article published on 01 November 2006

Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells

scientific article

Thrombin receptors and their antagonists: an update on the patent literature

scientific article

Total synthesis and biological evaluation of halipeptins A and D and analogues

scientific article published on April 2006

Upregulation of proteinase-activated receptors (PARs) and cardiovascular function

Urotensin II: A Novel Target in Human Corpus Cavernosum

cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.

scientific article

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